for Neuro-Oncology

Neurology

Staff

Soffietti Riccardo (Group leader)
Roberta Rudà (Member)
Palmiero Rosa (Member)
(Member)
Pellerino Alessia (Member)
Allegra Carpaneto (Assistant)
Erminia Muscolino (Technician)
Giulia Marchese (Technician)
Polly Graziani (Technician)

Contacts

Activity

The Research Group is concerned with primary and secondary tumors of the nervous system, neurological complications of extranervous cancer and related therapies. Different lines of research are in progress.

The main strand includes clinical and translational, institutional or multi-institutional, Italian or international, Phase II and III studies related to: new molecular drugs in glioblastoma (regorafenib, nivolumab); new antiangiogenic drugs in glioblastoma, in grade II and II glioma (bevacizumab); new molecular drugs in medulloblastoma (vismodegib); new antiangiogenic drug in ependymoma (bevacizumab); new molecular agents in primary CNS lymphoma (rituximab); new molecular agents in brain and leptomeningeal metastases from HER2+ breast cancer (neratinib); new antiepileptic drugs (lacosamide, perampanel); EORTC 26053 study on concomitant chemotherapy and adjuvant temozolomide in anaplastic glioma without deletion of 1p/19q, of which is the National Coordinator; IELSG study in newly diagnosed primary CNS lymphoma in elderly patients (FIORELLA).

A second line of research is related to the monitoring of therapies with advanced neuroimaging techniques, such as spectroscopy/perfusion MR, DTI, PET with Methionine.

A third line of research involves preoperative chemotherapy of grade II glioma.

A fourth line of research is to monitor cognitive processes and quality of life of patients with gliomas and medulloblastomas treated with chemotherapy or antiangiogenic drugs.

A fifth line of research is the research/validation of molecular biomarkers with prognostic/predictive purposes in gliomas and ependymomas.

A sixth line of research is the investigation of STAT3 in brain metastases.

The research group participates in the CERN (Collaborative Ependymoma Research Network, US) that aims to identify molecular profiles of prognostic significance in ependymomas and the BTG study on long-surviving patients with glioblastomas.

Group’s ECR Sectors:

LS4_6 - Cancer and its biological basis

LS5_10 - Neuroimaging and computational neuroscience

LS5_3 - Neurochemistry and neuropharmacology

LS5_7 - Cognition (e.g. learning, memory, emotions, speech)

LS7_2 - Diagnostic tools (e.g. genetic, imaging)

LS7_3 - Pharmacology, pharmacogenomics, drug discovery and design, drug therapy

LS7_8 - Health services, health care research

Publications

1. Soffietti R, Ahluwalia M, Lin N, Rudà R. Management of brain metastases according to molecular subtypes. Nat Rev Neurol. 2020 Sep 1. doi:10.1038/s41582-020-0391-x. Epub ahead of print. PMID: 32873927

2. Vogelbaum MA, Krivosheya D, Borghei-Razavi H, Sanai N, Weller M, Wick W, Soffietti R, Reardon DA, Aghi MK, Galanis E, Wen PY, van den Bent M, Chang S. Phase 0 and Window of Opportunity Clinical Trial Design in Neuro-Oncology: A RANO Review. Neuro Oncol. 2020 Jun 29:noaa149. doi: 10.1093/neuonc/noaa149. Epub ahead of print. PMID: 32598442.

3. Moro E, Priori A, Beghi E, Helbok R, Campiglio L, Bassetti CL, Bianchi E, Maia LF, Ozturk S, Cavallieri F, Zedde M, Sellner J, Bereczki D, Rakusa M, Di Liberto G, Sauerbier A, Pisani A, Macerollo A, Soffietti R, Taba P, Crean M, Twardzik A, Oreja-Guevara C, Bodini B, Jenkins TM, von Oertzen TJ; EAN core COVID-19 Task Force. The international European Academy of Neurology survey on neurological symptoms in patients with COVID-19 infection. Eur J Neurol. 2020 Jun 17:10.1111/ene.14407. doi: 10.1111/ene.14407. Epub ahead of print. PMID: 32558002; PMCID: PMC7323212.

4. Moro E, Deuschl G, de Visser M, Muresanu D, Soffietti R, Marson A, Vidailhet M, Vodusek DB, Bassetti CLA. A call from the European Academy of Neurology on COVID-19. Lancet Neurol. 2020 Jun;19(6):482. doi: 10.1016/S1474-4422(20)30151-4. Epub 2020 May 26. PMID: 32470415; PMCID: PMC7250552.

5. Donofrio CA, Cavalli A, Gemma M, Riccio L, Donofrio A, Panni P, Ferrari da Passano C, Del Vecchio A, Bolognesi A, Soffietti R, Mortini P. Cumulative intracranial tumour volume prognostic assessment: a new predicting score index for patients with brain metastases treated by stereotactic radiosurgery. Clin Exp Metastasis. 2020 Aug;37(4):499-508. doi: 10.1007/s10585-020-10037-z. Epub 2020 May 19. PMID: 32430649.

6. Rudà R, Angileri FF, Ius T, Silvani A, Sarubbo S, Solari A, Castellano A, Falini A, Pollo B, Del Basso De Caro M, Papagno C, Minniti G, De Paula U, Navarria P, Nicolato A, Salmaggi A, Pace A, Fabi A, Caffo M, Lombardi G, Carapella CM, Spena G, Iacoangeli M, Fontanella M, Germanò AF, Olivi A, Bello L, Esposito V, Skrap M, Soffietti R; SINch Neuro-Oncology Section, AINO and SIN Neuro-Oncology Section. Italian consensus and recommendations on diagnosis and
treatment of low-grade gliomas. An intersociety (SINch/AINO/SIN) document. J Neurosurg Sci. 2020 Aug;64(4):313-334. doi: 10.23736/S0390-5616.20.04982-6. Epub 2020 Apr 29. PMID: 32347684.

7. Le Rhun E, Seoane J, Salzet M, Soffietti R, Weller M. Liquid biopsies for diagnosing and monitoring primary tumors of the central nervous system. Cancer Lett. 2020 Jun 28;480:24-28. doi: 10.1016/j.canlet.2020.03.021. Epub 2020 Mar 27. PMID: 32229189.

8. Bruno F, Pellerino A, Bertero L, Soffietti R, Rudà R. Long-term survival of a sacro-coccygeal myxopapillary ependymoma with extra-neural metastases: case report and review of the literature. Neurol Sci. 2020 Jul;41(7):1955-1957. doi:10.1007/s10072-020-04269-w. Epub 2020 Jan 28. PMID: 31989347.

9. Gambella A, Senetta R, Collemi G, Vallero SG, Monticelli M, Cofano F, Zeppa P, Garbossa D, Pellerino A, Rudà R, Soffietti R, Fagioli F, Papotti M, Cassoni P, Bertero L. NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target. Int J Mol Sci. 2020 Jan 3;21(3):753. doi: 10.3390/ijms21030753.
PMID: 31979374; PMCID: PMC7037946.

10. Pellerino A, Bertero L, Rudà R, Soffietti R. Choosing appropriate chemotherapy for diffusely infiltrating WHO grade II gliomas in adults. Expert Opin Pharmacother. 2020 Apr;21(6):613-615. doi: 10.1080/14656566.2020.1714030.
Epub 2020 Jan 20. PMID: 31957509.

11. Rudà R, Soffietti R. Does an optimal management of brain metastases from oncogenic-driver non-small cell lung cancer exist? Neuro Oncol. 2020 Feb 20;22(2):171-172. doi: 10.1093/neuonc/noz238. PMID: 31858130; PMCID: PMC7032630.

12. Rudà R, Pellerino A, Pace A, Carapella CM, Dealis C, Caroli M, Faedi M, Bello L, Migliore E, Marchese G, Bertero L, Cassoni P, Soffietti R. Correction to: Efficacy of initial temozolomide for high‑risk low grade gliomas in a phase II AINO (Italian Association for Neuro‑Oncology) study: a post‑hoc analysis within molecular subgroups of WHO 2016. J Neurooncol. 2019 Dec;145(3):593. doi:10.1007/s11060-019-03331-8. Erratum for: J Neurooncol. 2019 Oct;145(1):115-123. PMID: 31691059.

13. Rudà R, Pellerino A, Pace A, Carapella CM, Dealis C, Caroli M, Faedi M, Bello L, Migliore E, Marchese G, Bertero L, Cassoni P, Soffietti R. Efficacy of initial temozolomide for high-risk low grade gliomas in a phase II AINO (Italian Association for Neuro-Oncology) study: a post-hoc analysis within molecular subgroups of WHO 2016. J Neurooncol. 2019 Oct;145(1):115-123. doi:10.1007/s11060-019-03277-x. Epub 2019 Sep 25. Erratum in:Jeurooncol.2019 Dec;145(3):593. PMID: 31556015.

14. Pasqualetti F, Restante G, Gonnelli A, Rofi E, Molinari A, Crucitta S, Paiar F, Rudà R, Danesi R, Soffietti R, Del Re M. Dabrafenib treatment in a patient with BRAF V600E ganglioglioma: circulating exosome-derived cancer RNA supports treatment choice and clinical monitoring. Neuro Oncol. 2019 Dec 17;21(12):1610-1611. doi: 10.1093/neuonc/noz157. PMID: 31504796; PMCID: PMC6917399.

15. Galldiks N, Kocher M, Ceccon G, Werner JM, Brunn A, Deckert M, Pope WB, Soffietti R, Le Rhun E, Weller M, Tonn JC, Fink GR, Langen KJ. Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression. Neuro Oncol. 2020 Jan 11;22(1):17-30. doi: 10.1093/neuonc/noz147. PMID: 31437274; PMCID: PMC6954406.

16. Soffietti R, Pellerino A, Rudà R. Strategies to prevent brain metastasis. Curr Opin Oncol. 2019 Nov;31(6):493-500. doi: 10.1097/CCO.0000000000000572.
PMID: 31414987.

17. Altieri R, Melcarne A, Soffietti R, Rudá R, Franchino F, Pellerino A, La Rocca G, Sabatino G, Olivi A, Ducati A, Zeppa P, Tardivo V, Mantovani C, Chiovatero I, Martini S, Dolce P, Savastano R, Lanotte MM, Zenga F, Garbossa D. Supratotal Resection of Glioblastoma: Is Less More? Surg Technol Int. 2019 Nov 10;35:432-440. PMID: 31373379.

18. Pellerino A, Buffoni L, Rudà R, Soffietti R. Complete response of spinal metastases from non-small cell lung cancer with ALK inhibitors. Neurology. 2019 Jul 30;93(5):217-219. doi: 10.1212/WNL.0000000000007866. Epub 2019 Jun 27. PMID:31248938.

19. Trajkova S, d'Errico A, Soffietti R, Sacerdote C, Ricceri F. Use of Antidepressants and Risk of Incident Stroke: A Systematic Review and Meta-Analysis. Neuroepidemiology. 2019;53(3-4):142-151. doi: 10.1159/000500686. Epub2019 Jun 19. PMID: 31216542.

20. Bertero L, Siravegna G, Rudà R, Soffietti R, Bardelli A, Cassoni P. Review: Peering through a keyhole: liquid biopsy in primary and metastatic central nervous system tumours. Neuropathol Appl Neurobiol. 2019 Dec;45(7):655-670. doi: 10.1111/nan.12553. Epub 2019 May 14. PMID: 30977933; PMCID: PMC6899864.

21. Riva M, Lopci E, Castellano A, Olivari L, Gallucci M, Pessina F, Fernandes B, Simonelli M, Navarria P, Grimaldi M, Rudà R, Castello A, Rossi M, Alfiero T, Soffietti R, Chiti A, Bello L. Lower Grade Gliomas: Relationships Between Metabolic and Structural Imaging with Grading and Molecular Factors. World Neurosurg. 2019 Jun;126:e270-e280. doi: 0.1016/j.wneu.2019.02.031. Epub 2019 Feb 22. PMID: 30797926.

22. Andratschke N, Kraft J, Nieder C, Tay R, Califano R, Soffietti R, Guckenberger M. Optimal management of brain metastases in oncogenic-driven non-small cell lung cancer (NSCLC). Lung Cancer. 2019 Mar;129:63-71. doi:10.1016/j.lungcan.2018.12.009. Epub 2018 Dec 10. PMID: 30797493.

23. Bertero L, Dalla Dea G, Osella-Abate S, Botta C, Castellano I, Morra I, Pollo B, Calatozzolo C, Patriarca S, Mantovani C, Rudà R, Tardivo V, Zenga F, Garbossa D, Papotti M, Soffietti R, Ricardi U, Cassoni P. Prognostic Characterization of Higher-Grade Meningiomas: A Histopathological Score to Predict Progression and Outcome. J Neuropathol Exp Neurol. 2019 Mar 1;78(3):248-256. doi: 10.1093/jnen/nly127. PMID: 30689922; PMCID: PMC6380327.

24. Boire A, Brandsma D, Brastianos PK, Le Rhun E, Ahluwalia M, Junck L, Glantz M, Groves MD, Lee EQ, Lin N, Raizer J, Rudà R, Weller M, Van den Bent MJ, Vogelbaum MA, Chang S, Wen PY, Soffietti R. Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications. Neuro Oncol. 2019 May 6;21(5):571-584. doi: 10.1093/neuonc/noz012. PMID: 30668804;PMCID: PMC6502489.

25. Achrol AS, Rennert RC, Anders C, Soffietti R, Ahluwalia MS, Nayak L, Peters S, Arvold ND, Harsh GR, Steeg PS, Chang SD. Brain metastases. Nat Rev Dis Primers. 2019 Jan 17;5(1):5. doi: 10.1038/s41572-018-0055-y. PMID: 30655533.

26. Galldiks N, Langen KJ, Albert NL, Chamberlain M, Soffietti R, Kim MM, Law I, Le Rhun E, Chang S, Schwarting J, Combs SE, Preusser M, Forsyth P, Pope W, Weller M, Tonn JC. PET imaging in patients with brain metastasis-report of the RANO/PET group. Neuro Oncol. 2019 May 6;21(5):585-595. doi:10.1093/neuonc/noz003. PMID: 30615138; PMCID: PMC6502495.

27. Lombardi G, De Salvo GL, Brandes AA, Eoli M, Rudà R, Faedi M, Lolli I, Pace A, Daniele B, Pasqualetti F, Rizzato S, Bellu L, Pambuku A, Farina M, Magni G, Indraccolo S, Gardiman MP, Soffietti R, Zagonel V. Regorafenib compared with lomustine in patients with relapsed glioblastoma (REGOMA): a multicentre, open-label, randomised, controlled, phase 2 trial. Lancet Oncol. 2019 Jan;20(1):110-119. doi: 10.1016/S1470-2045(18)30675-2. Epub 2018 Dec 3. PMID:30522967.

28. Pessina F, Navarria P, Clerici E, Soffietti R, Nibali MC, Rudà R, Riva M, Scorsetti M, Bello L. Intracranial Meningiomas: A Systematic Analysis of Prognostic Factors for Recurrence in a Large Single Institution Surgical Series. World Neurosurg. 2019 Mar;123:e273-e279. doi: 10.1016/j.wneu.2018.11.150. Epub 2018 Nov 26. PMID: 30496926.

29. Churilla TM, Chowdhury IH, Handorf E, Collette L, Collette S, Dong Y, Alexander BM, Kocher M, Soffietti R, Claus EB, Weiss SE. Comparison of Local Control of Brain Metastases With Stereotactic Radiosurgery vs Surgical Resection: A Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol. 2019 Feb 1;5(2):243-247. doi: 10.1001/jamaoncol.2018.4610. PMID: 30419088; PMCID:PMC6439566.

30. Soffietti R. Editorial: Hot Topics in Neuro-Oncology. Curr Opin Neurol. 2018 Dec;31(6):718-719. doi: 10.1097/WCO.0000000000000618. PMID: 30300242.

31. Pasqualetti F, Gonnelli A, Molinari A, Cantarella M, Montrone S, Cristaudo A, Baldaccini D, Mattioni R, Delishaj D, Mazzotti V, Morganti R, Cocuzza P, Fabrini MG, Lombardi G, Rudà R, Soffietti R, Paiar F. Different Timing to Use Bevacizumab in Patients with Recurrent Glioblastoma: Early Versus Delayed Administration. Anticancer Res. 2018 Oct;38(10):5877-5881. doi:10.21873/anticanres.12930. PMID: 30275213.

32. Bertero L, Anfossi V, Osella-Abate S, Disanto MG, Mantovani C, Zenga F, Rudà R, Garbossa D, Soffietti R, Ricardi U, Papotti M, Cassoni P. Pathological prognostic markers in central nervous system solitary fibrous tumour/hemangiopericytoma: Evidence from a small series. PLoS One. 2018 Sep 5;13(9):e0203570. doi: 10.1371/journal.pone.0203570. PMID: 30183767; PMCID:PMC6124774.

33. Huang RY, Bi WL, Weller M, Kaley T, Blakeley J, Dunn I, Galanis E, Preusser M, McDermott M, Rogers L, Raizer J, Schiff D, Soffietti R, Tonn JC, Vogelbaum M, Weber D, Reardon DA, Wen PY. Proposed response assessment and endpoints for meningioma clinical trials: report from the Response Assessment in Neuro-Oncology Working Group. Neuro Oncol. 2019 Jan 1;21(1):26-36. doi:10.1093/neuonc/noy137. PMID: 30137421; PMCID: PMC6303427.

34. Chiavazza C, Pellerino A, Ferrio F, Cistaro A, Soffietti R, Rudà R. Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring. Biomed Res Int. 2018 Jun 21;2018:3606970. doi: 10.1155/2018/3606970. PMID: 30035121; PMCID: PMC6033255.

35. Rudà R, Bruno F, Soffietti R. What Have We Learned from Recent Clinical Studies in Low-Grade Gliomas? Curr Treat Options Neurol. 2018 Jul 4;20(8):33. doi: 10.1007/s11940-018-0516-3. PMID: 29974266.

36. Soffietti R, Pellerino A, Rudà R. Neuro-oncology perspective of treatment options in metastatic breast cancer. Future Oncol. 2018 Jul;14(17):1765-1774. doi: 10.2217/fon-2017-0630. Epub 2018 Jun 29. PMID: 29956562.

37. Priego N, Zhu L, Monteiro C, Mulders M, Wasilewski D, Bindeman W, Doglio L, Martínez L, Martínez-Saez E, Ramón Y Cajal S, Megías D, Hernández-Encinas E, Blanco-Aparicio C, Martínez L, Zarzuela E, Muñoz J, Fustero-Torre C, Piñeiro-Yáñez E, Hernández-Laín A, Bertero L, Poli V, Sanchez-Martinez M, Menendez JA, Soffietti R, Bosch-Barrera J, Valiente M. Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis. Nat Med. 2018 Sep;24(9):1481. doi: 10.1038/s41591-018-0108-5. Erratum for: Nat Med. 2018 Jul;24(7):1024-1035. PMID: 29921958.

38. Priego N, Zhu L, Monteiro C, Mulders M, Wasilewski D, Bindeman W, Doglio L, Martínez L, Martínez-Saez E, Ramón Y Cajal S, Megías D, Hernández-Encinas E, Blanco-Aparicio C, Martínez L, Zarzuela E, Muñoz J, Fustero-Torre C, Piñeiro-Yáñez E, Hernández-Laín A, Bertero L, Poli V, Sanchez-Martinez M, Menendez JA, Soffietti R, Bosch-Barrera J, Valiente M. STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis. Nat Med. 2018
Jul;24(7):1024-1035. doi: 10.1038/s41591-018-0044-4. Epub 2018 Jun 11. Erratum
in: Nat Med. 2018 Jun 19;: PMID: 29892069.

39. Franchino F, Rudà R, Soffietti R. Mechanisms and Therapy for Cancer Metastasis to the Brain. Front Oncol. 2018 May 24;8:161. doi:10.3389/fonc.2018.00161. PMID: 29881714; PMCID: PMC5976742.

40. Pasqualetti F, Pace A, Gonnelli A, Villani V, Cantarella M, Delishaj D, Vivaldi C, Molinari A, Montrone S, Pellerino A, Franchino F, Baldaccini D, Lombardi G, Lolli I, Catania F, Bazzoli E, Morganti R, Fabi A, Zagonel V, Bocci G, Fabrini MG, Rudà R, Soffietti R, Paiar F. Single-agent Bevacizumab in Recurrent Glioblastoma After Second-line Chemotherapy With Fotemustine: The Experience of the Italian Association of Neuro-Oncology. Am J Clin Oncol. 2018
Dec;41(12):1272-1275. doi: 10.1097/COC.0000000000000464. PMID: 29782366.

41. Pellerino A, Franchino F, Soffietti R, Rudà R. Overview on current treatment standards in high-grade gliomas. Q J Nucl Med Mol Imaging. 2018 Sep;62(3):225-238. doi: 10.23736/S1824-4785.18.03096-0. Epub 2018 Apr 26. PMID:29696949.

42. Pedrosa RMSM, Mustafa DA, Soffietti R, Kros JM. Breast cancer brain metastasis: molecular mechanisms and directions for treatment. Neuro Oncol. 2018 Oct 9;20(11):1439-1449. doi: 10.1093/neuonc/noy044. PMID: 29566179; PMCID:PMC6176797.

43. Pellerino A, Bertero L, Rudà R, Soffietti R. Neoplastic meningitis in solid tumors: from diagnosis to personalized treatments. Ther Adv Neurol Disord. 2018 Mar 7;11:1756286418759618. doi: 10.1177/1756286418759618. PMID: 29535794; PMCID:PMC5844521.

44. Valiente M, Ahluwalia MS, Boire A, Brastianos PK, Goldberg SB, Lee EQ, LeRhun E, Preusser M, Winkler F, Soffietti R. The Evolving Landscape of Brain Metastasis. Trends Cancer. 2018 Mar;4(3):176-196. doi:10.1016/j.trecan.2018.01.003. Epub 2018 Feb 21. PMID: 29506669; PMCID:PMC6602095.

45. Soffietti R, Franchino F, Magistrello M, Pellerino A, Rudà R. Perspectives of Personalized Chemotherapy of Gliomas Based on Molecular Tumor Profiling. Prog Neurol Surg. 2018;31:168-179. doi: 10.1159/000467378. Epub 2018 Jan 25. PMID:29393185.

46. Alexander BM, Brown PD, Ahluwalia MS, Aoyama H, Baumert BG, Chang SM, Gaspar LE, Kalkanis SN, Macdonald DR, Mehta MP, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wefel JS, Lee EQ, Wen PY; Response Assessment in Neuro-Oncology (RANO) group. Clinical trial design for local therapies for brain metastases: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group. Lancet Oncol. 2018 Jan;19(1):e33-e42. doi: 10.1016/S1470-2045(17)30692-7. PMID: 29304360.

47. Camidge DR, Lee EQ, Lin NU, Margolin K, Ahluwalia MS, Bendszus M, Chang SM, Dancey J, de Vries EGE, Harris GJ, Hodi FS, Lassman AB, Macdonald DR, Peereboom DM, Schiff D, Soffietti R, van den Bent MJ, Wefel JS, Wen PY. Clinical trial design for systemic agents in patients with brain metastases from solid tumours: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group. Lancet Oncol. 2018 Jan;19(1):e20-e32. doi:10.1016/S1470-2045(17)30693-9. PMID: 29304358.

48. Rudà R, Soffietti R. Extent of surgery in low-grade gliomas: an old question in a new context. Neuro Oncol. 2018 Jan 10;20(1):6-7. doi:10.1093/neuonc/nox218. PMID: 29304249; PMCID: PMC5761504.

49. Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC. EANO guidelines for the diagnosis and treatment of ependymal tumors. Neuro Oncol. 2018 Mar 27;20(4):445-456. doi:10.1093/neuonc/nox166. PMID: 29194500; PMCID: PMC5909649.

50. Rudà R, Pellerino A, Franchino F, Bertolotti C, Bruno F, Mo F, Migliore E, Ciccone G, Soffietti R. Lacosamide in patients with gliomas and uncontrolled seizures: results from an observational study. J Neurooncol. 2018 Jan;136(1):105-114. doi: 10.1007/s11060-017-2628-0. Epub 2017 Oct 13. PMID:29030718.

51. Soffietti R, Chiavazza C, Rudà R. Imaging and clinical end points in brain metastases trials. CNS Oncol. 2017 Oct;6(4):243-246. doi: 10.2217/cns-2017-0017.Epub 2017 Oct 6. PMID: 28984137; PMCID: PMC6004884.

52. Navarria P, Pessina F, Tomatis S, Soffietti R, Grimaldi M, Lopci E, Chiti A, Leonetti A, Casarotti A, Rossi M, Cozzi L, Ascolese AM, Simonelli M, Marcheselli S, Santoro A, Clerici E, Bello L, Scorsetti M. Are three weeks hypofractionated radiation therapy (HFRT) comparable to six weeks for newly diagnosed glioblastoma patients? Results of a phase II study. Oncotarget. 2017 Jun 28;8(40):67696-67708. doi: 10.18632/oncotarget.18809. PMID: 28978064; PMCID:PMC5620204.

53. Churilla TM, Handorf E, Collette S, Collette L, Dong Y, Aizer AA, Kocher M, Soffietti R, Alexander BM, Weiss SE. Whole brain radiotherapy after stereotactic radiosurgery or surgical resection among patients with one to three brain metastases and favorable prognoses: a secondary analysis of EORTC 22952-26001. Ann Oncol. 2017 Oct 1;28(10):2588-2594. doi: 10.1093/annonc/mdx332. PMID:28961826; PMCID: PMC5834047.

54. Soffietti R. Does intensification of chemotherapy in anaplastic oligodendrogliomas still have a role? Neuro Oncol. 2017 Oct 1;19(10):1292-1293.doi: 10.1093/neuonc/nox146. PMID: 28922863; PMCID: PMC5596173.

55. Weller M, Butowski N, Tran DD, Recht LD, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust SA, Iwamoto F, Drappatz J, O'Rourke DM, Wong M, Hamilton MG, Finocchiaro G, Perry J, Wick W, Green J, He Y, Turner CD, Yellin MJ, Keler T, Davis TA, Stupp R, Sampson JH; ACT IV trial investigators. Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial. Lancet Oncol. 2017 Oct;18(10):1373-1385. doi: 10.1016/S1470-2045(17)30517-X. Epub 2017 Aug 23. PMID: 28844499.

56. Weller M, van den Bent M, Tonn JC, Stupp R, Preusser M, Cohen-Jonathan-Moyal E, Henriksson R, Le Rhun E, Balana C, Chinot O, Bendszus M, Reijneveld JC, Dhermain F, French P, Marosi C, Watts C, Oberg I, Pilkington G, Baumert BG, Taphoorn MJB, Hegi M, Westphal M, Reifenberger G, Soffietti R, Wick W; European Association for Neuro-Oncology (EANO) Task Force on Gliomas. Evidence-based management of adult patients with diffuse glioma - Authors' reply. Lancet Oncol. 2017 Aug;18(8):e430-e431. doi: 10.1016/S1470-2045(17)30515-6. Epub 2017 Jul 26. PMID: 28759377.

57. Aapro M, Astier A, Audisio R, Banks I, Bedossa P, Brain E, Cameron D, Casali P, Chiti A, De Mattos-Arruda L, Kelly D, Lacombe D, Nilsson PJ, Piccart M, Poortmans P, Riklund K, Saeter G, Schrappe M, Soffietti R, Travado L, van Poppel H, Wait S, Naredi P. Identifying critical steps towards improved access to innovation in cancer care: a European CanCer Organisation position paper. Eur J Cancer. 2017 Sep;82:193-202. doi: 10.1016/j.ejca.2017.04.014. Epub 2017 Jul 7. PMID: 28692951.

58. Lin NU, Gaspar LE, Soffietti R. Breast Cancer in the Central Nervous System: Multidisciplinary Considerations and Management. Am Soc Clin Oncol Educ Book.
2017;37:45-56. doi: 10.1200/EDBK_175338. PMID: 28561683.

59. Weller M, van den Bent M, Tonn JC, Stupp R, Preusser M, Cohen-Jonathan-Moyal E, Henriksson R, Le Rhun E, Balana C, Chinot O, Bendszus M, Reijneveld JC, Dhermain F, French P, Marosi C, Watts C, Oberg I, Pilkington G, Baumert BG, Taphoorn MJB, Hegi M, Westphal M, Reifenberger G, Soffietti R, Wick W; European Association for Neuro-Oncology (EANO) Task Force on Gliomas. European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas. Lancet Oncol. 2017
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60. Le Rhun E, Rudà R, Devos P, Hoang-Xuan K, Brandsma D, Pérez Segura P, Soffietti R, Weller M. Diagnosis and treatment patterns for patients with leptomeningeal metastasis from solid tumors across Europe. J Neurooncol. 2017 Jun;133(2):419-427. doi: 10.1007/s11060-017-2452-6. Epub 2017 Apr 28. PMID:28455788.

61. Nayak L, DeAngelis LM, Brandes AA, Peereboom DM, Galanis E, Lin NU, Soffietti R, Macdonald DR, Chamberlain M, Perry J, Jaeckle K, Mehta M, Stupp R, Muzikansky A, Pentsova E, Cloughesy T, Iwamoto FM, Tonn JC, Vogelbaum MA, Wen PY, van den Bent MJ, Reardon DA. The Neurologic Assessment in Neuro-Oncology (NANO) scale: a tool to assess neurologic function for integration into the Response Assessment in Neuro-Oncology (RANO) criteria. Neuro Oncol. 2017 May 1;19(5):625-635. doi: 10.1093/neuonc/nox029. PMID: 28453751; PMCID: PMC5464449.

62. Rudà R, Soffietti R. Controversies in management of low-grade gliomas in light of new data from clinical trials. Neuro Oncol. 2017 Feb 1;19(2):143-144. doi: 10.1093/neuonc/now275. PMID: 28391299; PMCID: PMC5464130.

63. Soffietti R, Abacioglu U, Baumert B, Combs SE, Kinhult S, Kros JM, Marosi C, Metellus P, Radbruch A, Villa Freixa SS, Brada M, Carapella CM, Preusser M, Le Rhun E, Rudà R, Tonn JC, Weber DC, Weller M. Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO). Neuro Oncol. 2017 Feb 1;19(2):162-174. doi:10.1093/neuonc/now241. PMID: 28391295; PMCID: PMC5620494.

64. Lopci E, Riva M, Olivari L, Raneri F, Soffietti R, Piccardo A, Bizzi A, Navarria P, Ascolese AM, Rudà R, Fernandes B, Pessina F, Grimaldi M, Simonelli M, Rossi M, Alfieri T, Zucali PA, Scorsetti M, Bello L, Chiti A. Prognostic value of molecular and imaging biomarkers in patients with supratentorial glioma. Eur J Nucl Med Mol Imaging. 2017 Jul;44(7):1155-1164. doi:10.1007/s00259-017-3618-3. Epub 2017 Jan 21. PMID: 28110346.

65. Chamberlain M, Junck L, Brandsma D, Soffietti R, Rudà R, Raizer J, Boogerd W, Taillibert S, Groves MD, Le Rhun E, Walker J, van den Bent M, Wen PY, Jaeckle KA. Leptomeningeal metastases: a RANO proposal for response criteria. Neuro Oncol. 2017 Apr 1;19(4):484-492. doi: 10.1093/neuonc/now183. PMID: 28039364;PMCID: PMC5464328.

66. Marchiò C, Mariani S, Bertero L, Di Bello C, Francia Di Celle P, Papotti M, Rudà R, Soffietti R, Cassoni P. Liquoral liquid biopsy in neoplastic meningitis enables molecular diagnosis and mutation tracking: a proof of concept. Neuro Oncol. 2017 Mar 1;19(3):451-453. doi: 10.1093/neuonc/now244. PMID: 27838647;PMCID: PMC5464358.

67. Rudà R, Franchino F, Soffietti R. Treatment of brain metastasis: current status and future directions. Curr Opin Oncol. 2016 Nov;28(6):502-510. doi:10.1097/CCO.0000000000000326. PMID: 27606695.

68. Pellerino A, Rudà R, Bertero L, Magistrello M, Franchino F, Cassoni P, Pasqualetti F, Pinessi L, Giangaspero F, Soffietti R. Successful use of bevacizumab in an adult primary diffuse leptomeningeal glioneuronal tumor. J Neurosurg Sci. 2018 Apr;62(2):229-232. doi: 10.23736/S0390-5616.16.03804-2. Epub 2016 Sep 27. PMID: 27676284.

69. Nicolotto E, Presas-Rodriguez S, Morra I, Franchino F, Magistrello M, Pellerino A, Massaro F, Pinessi L, Rudà R, Soffietti R. Spinal melanocytoma with leptomeningeal spread and long survival following surgery and chemotherapy. J Neurosurg Sci. 2018 Jun;62(3):375-378. doi: 10.23736/S0390-5616.16.03687-0. Epub 2016 Sep 27. PMID: 27676283.

70. Goldbrunner R, Minniti G, Preusser M, Jenkinson MD, Sallabanda K, Houdart E, von Deimling A, Stavrinou P, Lefranc F, Lund-Johansen M, Moyal EC, Brandsma D, Henriksson R, Soffietti R, Weller M. EANO guidelines for the diagnosis and treatment of meningiomas. Lancet Oncol. 2016 Sep;17(9):e383-91. doi:10.1016/S1470-2045(16)30321-7. Epub 2016 Aug 30. PMID: 27599143.

71. Chiavazza C, Cistaro A, Fania P, Bertolotto A, Cavalla P, Rudà R, Pinessi L, Soffietti R. Reversible disconnection syndrome in a case of acute tumefactive demyelinating lesion: a PET study. Neurol Sci. 2016 Dec;37(12):2019-2023. doi:10.1007/s10072-016-2675-x. Epub 2016 Jul 25. PMID: 27457655.

72. Arvold ND, Lee EQ, Mehta MP, Margolin K, Alexander BM, Lin NU, Anders CK, Soffietti R, Camidge DR, Vogelbaum MA, Dunn IF, Wen PY. Updates in the management of brain metastases. Neuro Oncol. 2016 Aug;18(8):1043-65. doi:10.1093/neuonc/now127. PMID: 27382120; PMCID: PMC4933491.

73. Ramaswamy V, Hielscher T, Mack SC, Lassaletta A, Lin T, Pajtler KW, Jones DT, Luu B, Cavalli FM, Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon RE, Lipp ES, Dunham C, Hukin J, Eisenstat DD, Fulton D, van Landeghem FK, Santi M, van Veelen ML, Van Meir EG, Osuka S, Fan X, Muraszko KM, Tirapelli DP, Oba-Shinjo SM, Marie SK, Carlotti CG, Lee JY, Rao AA, Giannini C, Faria CC, Nunes S, Mora J, Hamilton RL, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognár L, Klekner A, Hortobágyi T, Leary S, Ermoian RP, Olson JM, Leonard JR, Gardner C, Grajkowska WA, Chambless LB, Cain J, Eberhart CG, Ahsan S, Massimino M, Giangaspero F, Buttarelli FR, Packer RJ, Emery L, Yong
WH, Soto H, Liau LM, Everson R, Grossbach A, Shalaby T, Grotzer M, Karajannis MA, Zagzag D, Wheeler H, von Hoff K, Alonso MM, Tuñon T, Schüller U, Zitterbart K, Sterba J, Chan JA, Guzman M, Elbabaa SK, Colman H, Dhall G, Fisher PG, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro AM, Pollack IF, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins CE, Rutka JT, Dirks P, Pfister SM, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Ellison DW, Taylor MD. Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis. J Clin Oncol. 2016 Jul 20;34(21):2468-77. doi:10.1200/JCO.2015.65.7825. Epub 2016 Jun 6. PMID: 27269943; PMCID: PMC4962737.

74. Albert NL, Weller M, Suchorska B, Galldiks N, Soffietti R, Kim MM, la Fougère C, Pope W, Law I, Arbizu J, Chamberlain MC, Vogelbaum M, Ellingson BM, Tonn JC. Response Assessment in Neuro-Oncology working group and European Association for Neuro-Oncology recommendations for the clinical use of PET imaging in gliomas. Neuro Oncol. 2016 Sep;18(9):1199-208. doi:10.1093/neuonc/now058. Epub 2016 Apr 21. PMID: 27106405; PMCID: PMC4999003.

75. Duregon E, Bertero L, Pittaro A, Soffietti R, Rudà R, Trevisan M, Papotti M, Ventura L, Senetta R, Cassoni P. Ki-67 proliferation index but not mitotic thresholds integrates the molecular prognostic stratification of lower grade gliomas. Oncotarget. 2016 Apr 19;7(16):21190-8. doi: 10.18632/oncotarget.8498. PMID: 27049832; PMCID: PMC5008278.

76. Rudà R, Pellerino A, Soffietti R. Does valproic acid affect tumor growth and improve survival in glioblastomas? CNS Oncol. 2016;5(2):51-3. doi:10.2217/cns-2016-0004. Epub 2016 Mar 17. PMID: 26985579; PMCID: PMC6047433.

77. Soffietti R, Rudà R, Reardon D. Rare glial tumors. Handb Clin Neurol.2016;134:399-415. doi: 10.1016/B978-0-12-802997-8.00024-4. PMID: 26948368.

78. Soffietti R, Rudà R, Trakul N, Chang EL. Point/Counterpoint: Is stereotactic radiosurgery needed following resection of brain metastasis? Neuro Oncol. 2016 Jan;18(1):12-5. doi: 10.1093/neuonc/nov286. PMID: 26667138; PMCID: PMC4677423.

79. Pellerino A, Soffietti R, Rudà R. Temozolomide for recurrent meningiomas: a case-report with unexpected clinical and radiological response. J Neurooncol. 2016 Mar;127(1):201-3. doi: 10.1007/s11060-015-2016-6. Epub 2015 Nov 27. PMID:26614515.

80. Roelcke U, Wyss MT, Nowosielski M, Rudà R, Roth P, Hofer S, Galldiks N, Crippa F, Weller M, Soffietti R. Amino acid positron emission tomography to monitor chemotherapy response and predict seizure control and progression-free survival in WHO grade II gliomas. Neuro Oncol. 2016 May;18(5):744-51. doi:10.1093/neuonc/nov282. Epub 2015 Nov 17. PMID: 26578622; PMCID: PMC4827046.

81. Furtner J, Schöpf V, Seystahl K, Le Rhun E, Rudà R, Roelcke U, Koeppen S, Berghoff AS, Marosi C, Clement P, Faedi M, Watts C, Wick W, Soffietti R, Weller M, Preusser M. Kinetics of tumor size and peritumoral brain edema before, during, and after systemic therapy in recurrent WHO grade II or III meningioma. Neuro Oncol. 2016 Mar;18(3):401-7. doi: 10.1093/neuonc/nov183. Epub 2015 Sep 9. PMID: 26354929; PMCID: PMC4767240.

82. Rudà R, Bosa C, Magistrello M, Franchino F, Pellerino A, Fiano V, Trevisan M, Cassoni P, Soffietti R. Temozolomide as salvage treatment for recurrent intracranial ependymomas of the adult: a retrospective study. Neuro Oncol. 2016 Feb;18(2):261-8. doi: 10.1093/neuonc/nov167. Epub 2015 Aug 30. PMID: 26323606;PMCID: PMC4724181.

83. Castellano A, Donativi M, Rudà R, De Nunzio G, Riva M, Iadanza A, Bertero L, Rucco M, Bello L, Soffietti R, Falini A. Evaluation of low-grade glioma structural changes after chemotherapy using DTI-based histogram analysis and functional diffusion maps. Eur Radiol. 2016 May;26(5):1263-73. doi:10.1007/s00330-015-3934-6. Epub 2015 Aug 30. PMID: 26318368.

84. Rudà R, Pellerino A, Magistrello M, Franchino F, Pinessi L, Soffietti R. Molecularly based management of gliomas in clinical practice. Neurol Sci. 2015 Sep;36(9):1551-7. doi: 10.1007/s10072-015-2332-9. Epub 2015 Jul 21. PMID:26194534.

85. Hoang-Xuan K, Bessell E, Bromberg J, Hottinger AF, Preusser M, Rudà R, Schlegel U, Siegal T, Soussain C, Abacioglu U, Cassoux N, Deckert M, Dirven CM, Ferreri AJ, Graus F, Henriksson R, Herrlinger U, Taphoorn M, Soffietti R, Weller M; European Association for Neuro-Oncology Task Force on Primary CNS Lymphoma. Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the European Association for Neuro-Oncology. Lancet Oncol. 2015 Jul;16(7):e322-32. doi: 10.1016/S1470-2045(15)00076-5. PMID: 26149884.

86. Scorsetti M, Navarria P, Pessina F, Ascolese AM, D'Agostino G, Tomatis S, DeRose F, Villa E, Maggi G, Simonelli M, Clerici E, Soffietti R, Santoro A, Cozzi L, Bello L. Multimodality therapy approaches, local and systemic treatment, compared with chemotherapy alone in recurrent glioblastoma. BMC Cancer. 2015 Jun 30;15:486. doi: 10.1186/s12885-015-1488-2. PMID: 26118437; PMCID: PMC4484625.

87. Barault L, Amatu A, Bleeker FE, Moutinho C, Falcomatà C, Fiano V, Cassingena A, Siravegna G, Milione M, Cassoni P, De Braud F, Rudà R, Soffietti R, Venesio T, Bardelli A, Wesseling P, de Witt Hamer P, Pietrantonio F, Siena S, Esteller M, Sartore-Bianchi A, Di Nicolantonio F. Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer. Ann Oncol. 2015 Sep;26(9):1994-1999. doi: 10.1093/annonc/mdv272. Epub 2015 Jun 25. PMID:
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88. Sponghini AP, Platini F, Rondonotti D, Soffietti R. Bevacizumab treatment for vestibular schwannoma in a patient with neurofibromatosis type 2: hearing improvement and tumor shrinkage. Tumori. 2015 Nov 14;101(6):e167-70. doi:10.5301/tj.5000313. PMID: 26108240.

89. Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY; Response Assessment in Neuro-Oncology (RANO) group. Response assessment criteria for brain metastases: proposal from the RANO group. Lancet Oncol. 2015 Jun;16(6):e270-8. doi: 10.1016/S1470-2045(15)70057-4. Epub 2015 May 27. PMID: 26065612.

90. Rudà R, Soffietti R. What is New in the Management of Epilepsy in Gliomas? Curr Treat Options Neurol. 2015 Jun;17(6):351. doi: 10.1007/s11940-015-0351-8.PMID: 25912245.

91. Trevisan E, Bertero L, Magistrello M, Rudà R, Soffietti R. Is there a Role for Bevacizumab in Non-Glial Tumors? Curr Drug Targets. 2015;16(7):684-8. doi:10.2174/1389450116666150325230810. PMID: 25808649.

92. Vidone M, Clima R, Santorsola M, Calabrese C, Girolimetti G, Kurelac I, Amato LB, Iommarini L, Trevisan E, Leone M, Soffietti R, Morra I, Faccani G, Attimonelli M, Porcelli AM, Gasparre G. A comprehensive characterization of mitochondrial DNA mutations in glioblastoma multiforme. Int J Biochem Cell Biol. 2015 Jun;63:46-54. doi: 10.1016/j.biocel.2015.01.027. Epub 2015 Feb 7. PMID:25668474.

93. Soffietti R, Bertero L, Pinessi L, Rudà R. Pharmacologic therapies for malignant glioma: a guide for clinicians. CNS Drugs. 2014 Dec;28(12):1127-37. doi: 10.1007/s40263-014-0215-x. PMID: 25403944.

94. Vera-Bolanos E, Aldape K, Yuan Y, Wu J, Wani K, Necesito-Reyes MJ, Colman H, Dhall G, Lieberman FS, Metellus P, Mikkelsen T, Omuro A, Partap S, Prados M, Robins HI, Soffietti R, Wu J, Gilbert MR, Armstrong TS; CERN Foundation. Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients. Neuro Oncol. 2015 Mar;17(3):440-7. doi:10.1093/neuonc/nou162. Epub 2014 Aug 13. PMID: 25121770; PMCID: PMC4483095.

95. Weller M, van den Bent M, Hopkins K, Tonn JC, Stupp R, Falini A, Cohen-Jonathan-Moyal E, Frappaz D, Henriksson R, Balana C, Chinot O, Ram Z, Reifenberger G, Soffietti R, Wick W; European Association for Neuro-Oncology (EANO) Task Force on Malignant Glioma. EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. Lancet Oncol. 2014 Aug;15(9):e395-403. doi: 10.1016/S1470-2045(14)70011-7. Erratum in: Lancet
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96. Valentini V, Abrahamsson PA, Aranda SK, Astier A, Audisio RA, Boniol M, Bonomo L, Brunelli A, Bultz B, Chiti A, De Lorenzo F, Eriksen JG, Goh V, Gospodarowicz MK, Grassi L, Kelly J, Kortmann RD, Kutluk T, Plate A, Poston G, Saarto T, Soffietti R, Torresin A, van Harten WH, Verzijlbergen JF, von Kalle C, Poortmans P. Still a long way to go to achieve multidisciplinarity for the benefit of patients: commentary on the ESMO position paper (Annals of Oncology 25(1): 9-15, 2014). Ann Oncol. 2014 Sep;25(9):1863-1865. doi:
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97. Chamberlain M, Soffietti R, Raizer J, Rudà R, Brandsma D, Boogerd W, Taillibert S, Groves MD, Le Rhun E, Junck L, van den Bent M, Wen PY, Jaeckle KA. Leptomeningeal metastasis: a Response Assessment in Neuro-Oncology critical review of endpoints and response criteria of published randomized clinical trials. Neuro Oncol. 2014 Sep;16(9):1176-85. doi: 10.1093/neuonc/nou089. Epub 2014 May 27. PMID: 24867803; PMCID: PMC4136900.

98. Fiano V, Trevisan M, Trevisan E, Senetta R, Castiglione A, Sacerdote C, Gillio-Tos A, De Marco L, Grasso C, Magistrello M, Tondat F, Rudà R, Cassoni P, Soffietti R, Merletti F. MGMT promoter methylation in plasma of glioma patients receiving temozolomide. J Neurooncol. 2014 Apr;117(2):347-57. doi:10.1007/s11060-014-1395-4. Epub 2014 Feb 12. PMID: 24519517.

99. Trevisan E, Bertero L, Bosa C, Magistrello M, Pellerino A, Rudà R, Soffietti R. Antiangiogenic therapy of brain tumors: the role of bevacizumab. Neurol Sci. 2014 Apr;35(4):507-14. doi: 10.1007/s10072-014-1627-6. Epub 2014 Jan 18. PMID:24442487.

100. Soffietti R, Trevisan E, Rudà R. What have we learned from trials on antiangiogenic agents in glioblastoma? Expert Rev Neurother. 2014 Jan;14(1):1-3. doi: 10.1586/14737175.2014.873277. PMID: 24417499.

101. Soffietti R, Trevisan E, Rudà R. Neurologic complications of chemotherapy and other newer and experimental approaches. Handb Clin Neurol. 2014;121:1199-218. doi: 10.1016/B978-0-7020-4088-7.00080-8. PMID: 24365412.

102. Weller M, Soffietti R, Brada M. The legend of cytomegalovirus and glioblastoma lives on. Neuro Oncol. 2014 Jan;16(1):166. doi:10.1093/neuonc/not204. Epub 2013 Dec 4. PMID: 24311642; PMCID: PMC3870830.

103. Huse JT, Wallace M, Aldape KD, Berger MS, Bettegowda C, Brat DJ, Cahill DP, Cloughesy T, Haas-Kogan DA, Marra M, Miller CR, Nelson SJ, Salama SR, Soffietti R, Wen PY, Yip S, Yen K, Costello JF, Chang S. Where are we now? And where are we going? A report from the Accelerate Brain Cancer Cure (ABC2) low-grade glioma research workshop. Neuro Oncol. 2014 Jan;16(2):173-8. doi:10.1093/neuonc/not229. Epub 2013 Dec 4. PMID: 24305708; PMCID: PMC3895389.

104. Soffietti R, Trevisan E, Bertero L, Cassoni P, Morra I, Fabrini MG, Pasqualetti F, Lolli I, Castiglione A, Ciccone G, Rudà R. Bevacizumab and fotemustine for recurrent glioblastoma: a phase II study of AINO (Italian Association of Neuro-Oncology). J Neurooncol. 2014 Feb;116(3):533-41. doi:10.1007/s11060-013-1317-x. Epub 2013 Dec 1. PMID: 24293233; PMCID: PMC3905193.

105. Lin NU, Wefel JS, Lee EQ, Schiff D, van den Bent MJ, Soffietti R, Suh JH, Vogelbaum MA, Mehta MP, Dancey J, Linskey ME, Camidge DR, Aoyama H, Brown PD, Chang SM, Kalkanis SN, Barani IJ, Baumert BG, Gaspar LE, Hodi FS, Macdonald DR, Wen PY; Response Assessment in Neuro-Oncology (RANO) group. Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group. Lancet Oncol. 2013 Sep;14(10):e407-16. doi: 10.1016/S1470-2045(13)70308-5. PMID:23993385.

106. Lin NU, Lee EQ, Aoyama H, Barani IJ, Baumert BG, Brown PD, Camidge DR, Chang SM, Dancey J, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Lamborn KR, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wefel JS, Wen PY; Response Assessment in Neuro-Oncology (RANO) group. Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group. Lancet Oncol. 2013 Sep;14(10):e396-406. doi:10.1016/S1470-2045(13)70311-5. PMID: 23993384.

107. Soffietti R. Reply to M.C. Chamberlain and C. Gemici. J Clin Oncol. 2013 Jul 10;31(20):2636-7. doi: 10.1200/JCO.2013.49.4443. PMID: 23991432.

108. Rudà R, Magliola U, Bertero L, Trevisan E, Bosa C, Mantovani C, Ricardi U, Castiglione A, Monagheddu C, Soffietti R. Seizure control following radiotherapy in patients with diffuse gliomas: a retrospective study. Neuro Oncol. 2013 Dec;15(12):1739-49. doi: 10.1093/neuonc/not109. Epub 2013 Jul 28. PMID:23897633; PMCID: PMC3829585.

109. Lolli I, Morra I, Cimmino A, Trevisan E, Rudà R, Piombino M, Campanella G, Gillio Tos A, De Marco L, Trevisan M, Fiano V, Soffietti R. Solitary brain metastasis as first manifestation of small-cell parotid gland carcinoma with high sensitivity to temozolomide therapy on basis of tumor O6-methylguanine-DNA-methyltransferase expression. J Clin Oncol. 2013 Aug 10;31(23):e394-7. doi:10.1200/JCO.2012.47.5590. Epub 2013 Jun 24. PMID: 23796990.

110. Soffietti R. Ependymoma: current treatment options and a look to the future. CNS Oncol. 2013 May;2(3):223-5. doi: 10.2217/cns.13.10. PMID: 25054462;PMCID: PMC6166535.

111. Raghunathan A, Wani K, Armstrong TS, Vera-Bolanos E, Fouladi M, Gilbertson R, Gajjar A, Goldman S, Lehman NL, Metellus P, Mikkelsen T, Necesito-Reyes MJ, Omuro A, Packer RJ, Partap S, Pollack IF, Prados MD, Robins HI, Soffietti R, Wu J, Miller CR, Gilbert MR, Aldape KD; Collaborative Ependymoma Research Network. Histological predictors of outcome in ependymoma are dependent on anatomic site within the central nervous system. Brain Pathol. 2013 Sep;23(5):584-94. doi:10.1111/bpa.12050. Epub 2013 Mar 28. PMID: 23452038.

112. Soffietti R, Kocher M, Abacioglu UM, Villa S, Fauchon F, Baumert BG, Fariselli L, Tzuk-Shina T, Kortmann RD, Carrie C, Ben Hassel M, Kouri M, Valeinis E, van den Berge D, Mueller RP, Tridello G, Collette L, Bottomley A. A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality-of-life results. J Clin Oncol. 2013 Jan 1;31(1):65-72. doi: 10.1200/JCO.2011.41.0639. Epub 2012 Dec 3. PMID: 23213105.

113. Rudà R, Bello L, Duffau H, Soffietti R. Seizures in low-grade gliomas:natural history, pathogenesis, and outcome after treatments. Neuro Oncol. 2012 Sep;14 Suppl 4(Suppl 4):iv55-64. doi: 10.1093/neuonc/nos199. PMID: 23095831;PMCID: PMC3480244.

114. Preusser M, Winkler F, Collette L, Haller S, Marreaud S, Soffietti R, Klein M, Reijneveld JC, Tonn JC, Baumert BG, Mulvenna P, Schadendorf D, Duchnowska R, Berghoff AS, Lin N, Cameron DA, Belkacemi Y, Jassem J, Weber DC. Trial design on prophylaxis and treatment of brain metastases: lessons learned from the EORTC Brain Metastases Strategic Meeting 2012. Eur J Cancer. 2012 Dec;48(18):3439-47. doi: 10.1016/j.ejca.2012.07.002. Epub 2012 Aug 8. PMID: 22883982.

115. Soffietti R, Trevisan E, Rudà R. Targeted therapy in brain metastasis. Curr Opin Oncol. 2012 Nov;24(6):679-86. doi: 10.1097/CCO.0b013e3283571a1c. PMID:22820413.

116. Wani K, Armstrong TS, Vera-Bolanos E, Raghunathan A, Ellison D, Gilbertson R, Vaillant B, Goldman S, Packer RJ, Fouladi M, Pollack I, Mikkelsen T, Prados M, Omuro A, Soffietti R, Ledoux A, Wilson C, Long L, Gilbert MR, Aldape K; Collaborative Ependymoma Research Network. A prognostic gene expression signature in infratentorial ependymoma. Acta Neuropathol. 2012 May;123(5):727-38. doi: 10.1007/s00401-012-0941-4. Epub 2012 Feb 10. PMID:22322993; PMCID: PMC4013829.

117. Soffietti R, Ducati A, Rudà R. Brain metastases. Handb Clin Neurol.2012;105:747-55. doi: 10.1016/B978-0-444-53502-3.00021-5. PMID: 22230531.

118. Newton HB, Rudà R, Soffietti R. Ependymomas, neuronal and mixed neuronal-glial tumors, dysembroblastic neuroepithelial tumors, pleomorphic xanthoastrocytomas, and pilocytic astrocytomas. Handb Clin Neurol. 2012;105:551-67. doi: 10.1016/B978-0-444-53502-3.00008-2. PMID: 22230518.

119. Rudà R, Trevisan E, Soffietti R. Low-grade gliomas. Handb Clin Neurol.2012;105:437-50. doi: 10.1016/B978-0-444-53502-3.00001-X. PMID: 22230511.

120. Soffietti R, Trevisan E, Bertero L, Bosa C, Ruda R. Anti-angiogenic approaches to malignant gliomas. Curr Cancer Drug Targets. 2012 Mar;12(3):279-88. doi: 10.2174/156800912799277584. PMID: 22229250.

121. Crocetti E, Trama A, Stiller C, Caldarella A, Soffietti R, Jaal J, Weber DC, Ricardi U, Slowinski J, Brandes A; RARECARE working group. Epidemiology of glial and non-glial brain tumours in Europe. Eur J Cancer. 2012 Jul;48(10):1532-42. doi: 10.1016/j.ejca.2011.12.013. Epub 2012 Jan 7. PMID:22227039.

122. Blonski M, Taillandier L, Herbet G, Maldonado IL, Beauchesne P, Fabbro M, Campello C, Gozé C, Rigau V, Moritz-Gasser S, Kerr C, Rudà R, Soffietti R, Bauchet L, Duffau H. Combination of neoadjuvant chemotherapy followed by surgical resection as a new strategy for WHO grade II gliomas: a study of cognitive status and quality of life. J Neurooncol. 2012 Jan;106(2):353-66. doi:10.1007/s11060-011-0670-x. Epub 2011 Jul 22. PMID: 21785913.

123. Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert BG, Fariselli L, Tzuk-Shina T, Kortmann RD, Carrie C, Ben Hassel M, Kouri M, Valeinis E, van den Berge D, Collette S, Collette L, Mueller RP. Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol. 2011 Jan 10;29(2):134-41. doi: 10.1200/JCO.2010.30.1655. Epub 2010 Nov 1. PMID: 21041710; PMCID: PMC3058272.

124. Titulaer MJ, Soffietti R, Dalmau J, Gilhus NE, Giometto B, Graus F, Grisold W, Honnorat J, Sillevis Smitt PA, Tanasescu R, Vedeler CA, Voltz R, Verschuuren JJ; European Federation of Neurological Societies. Screening for tumours in paraneoplastic syndromes: report of an EFNS task force. Eur J Neurol. 2011 Jan;18(1):19-e3. doi: 10.1111/j.1468-1331.2010.03220.x. Epub 2010 Sep 29. PMID:20880069; PMCID: PMC3086523.

125. Soffietti R, Baumert BG, Bello L, von Deimling A, Duffau H, Frénay M, Grisold W, Grant R, Graus F, Hoang-Xuan K, Klein M, Melin B, Rees J, Siegal T, Smits A, Stupp R, Wick W; European Federation of Neurological Societies. Guidelines on management of low-grade gliomas: report of an EFNS-EANO Task Force. Eur J Neurol. 2010 Sep;17(9):1124-33. doi:
10.1111/j.1468-1331.2010.03151.x. PMID: 20718851.

126. Rudà R, Trevisan E, Soffietti R. Epilepsy and brain tumors. Curr Opin Oncol. 2010 Nov;22(6):611-20. doi: 10.1097/CCO.0b013e32833de99d. PMID: 20706121.

127. Gilbert MR, Ruda R, Soffietti R. Ependymomas in adults. Curr Neurol Neurosci Rep. 2010 May;10(3):240-7. doi: 10.1007/s11910-010-0109-3. PMID:20425040.

128. Passarin MG, Moretto G, Musso AM, Ottaviani S, Masotto B, Ghimenton C, Iuzzolino P, Buffone E, Rudà R, Soffietti R, Vattemi E, Pedersini R. Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination. J Neurooncol. 2010 May;97(3):439-44. doi: 10.1007/s11060-009-0040-0. Epub 2009 Oct 31. PMID:19876600.

129. Ferreri AJ, Reni M, Foppoli M, Martelli M, Pangalis GA, Frezzato M, Cabras MG, Fabbri A, Corazzelli G, Ilariucci F, Rossi G, Soffietti R, Stelitano C, Vallisa D, Zaja F, Zoppegno L, Aondio GM, Avvisati G, Balzarotti M, Brandes AA, Fajardo J, Gomez H, Guarini A, Pinotti G, Rigacci L, Uhlmann C, Picozzi P, Vezzulli P, Ponzoni M, Zucca E, Caligaris-Cappio F, Cavalli F; International Extranodal Lymphoma Study Group (IELSG). High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS
lymphoma: a randomised phase 2 trial. Lancet. 2009 Oct 31;374(9700):1512-20. doi: 10.1016/S0140-6736(09)61416-1. Epub 2009 Sep 18. PMID: 19767089.

130. Soffietti R, Akerley W, Jensen RL, Bischoff J, Regierer AC. The role of intra-cerebrospinal fluid treatment and prophylaxis in patients with solid tumors. Semin Oncol. 2009 Aug;36(4 Suppl 2):S55-68. doi:10.1053/j.seminoncol.2009.05.007. PMID: 19660684.

131. Senetta R, Trevisan E, Rudà R, Benech F, Soffietti R, Cassoni P. Skin metastases of glioblastoma in the absence of intracranial progression are associated with a shift towards a mesenchymal immunophenotype: report of two cases. Acta Neuropathol. 2009 Aug;118(2):313-6. doi: 10.1007/s00401-009-0543-y.Epub 2009 May 6. PMID: 19418061.

132. Senetta R, Trevisan E, Rudà R, Maldi E, Molinaro L, Lefranc F, Chiusa L, Lanotte M, Soffietti R, Cassoni P. Caveolin 1 expression independently predicts shorter survival in oligodendrogliomas. J Neuropathol Exp Neurol. 2009 Apr;68(4):425-31. doi: 10.1097/NEN.0b013e31819ed0b7. PMID: 19287309.

133. Rudà R, Gilbert M, Soffietti R. Ependymomas of the adult: molecular biology and treatment. Curr Opin Neurol. 2008 Dec;21(6):754-61. doi:10.1097/WCO.0b013e328317efe8. PMID: 18989122.

134. Soffietti R, Rudà R, Trevisan E. Brain metastases: current management and new developments. Curr Opin Oncol. 2008 Nov;20(6):676-84. doi:10.1097/CCO.0b013e32831186fe. PMID: 18841050.

135. Ferreri AJ, Dognini GP, Bairey O, Szomor A, Montalbán C, Horvath B, Demeter J, Uziel L, Soffietti R, Seymour JF, Ambrosetti A, Willemze R, Martelli M, Rossi G, Candoni A, De Renzo A, Doglioni C, Zucca E, Cavalli F, Ponzoni M; International Extranodal Lymphoma Study Group. The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma. Br J Haematol. 2008
Oct;143(2):253-7. doi: 10.1111/j.1365-2141.2008.07338.x. Epub 2008 Aug 10. PMID:
18699850.

136. Salmaggi A, Fariselli L, Milanesi I, Lamperti E, Silvani A, Bizzi A, Maccagnano E, Trevisan E, Laguzzi E, Rudà R, Boiardi A, Soffietti R; Associazione Italiana di Neuro-oncologia. Natural history and management of brainstem gliomas in adults. A retrospective Italian study. J Neurol. 2008 Feb;255(2):171-7. doi: 10.1007/s00415-008-0589-0. Epub 2008 Feb 25. PMID:
18293027.

137. Greco Crasto S, Soffietti R, Rudà R, Cassoni P, Ducati A, Davini O, De Lucchi R, Rizzo L. Diffusion-Weighted Magnetic Resonance Imaging and ADC Maps in the Diagnosis of Intracranial Cystic or Necrotic Lesions. A Retrospective Study on 49 Patients. Neuroradiol J. 2007 Dec 31;20(6):666-75. doi:10.1177/197140090702000611. Epub 2007 Dec 31. PMID: 24300002.

138. Soffietti R, Rudà R. Neuro-oncology: new insights and advances in treatment. Lancet Neurol. 2008 Jan;7(1):14-6. doi:10.1016/S1474-4422(07)70305-8. PMID: 18093552.

139. Soffietti R, Leoncini B, Rudà R. New developments in the treatment of malignant gliomas. Expert Rev Neurother. 2007 Oct;7(10):1313-26. doi:10.1586/14737175.7.10.1313. PMID: 17939769.

140. Soffietti R, Rudà R, Trevisan E. New chemotherapy options for the treatment of malignant gliomas. Anticancer Drugs. 2007 Jul;18(6):621-32. doi:10.1097/CAD.0b013e32801476fd. PMID: 17762390.

141. Soffietti R. Prospettive future [Future prospects]. Tumori. 2007 May-Jun;93(3):suppl 14-5. Italian. PMID: 17679483.

142. Rudà R, Leoncini B, Laguzzi E, Trevisan E, Guarneri D, Bertetto O, Soffietti R. Efficacia della citarabina liposomiale nella meningite neoplastica [Efficacy of liposomal cytarabine in neoplastic meningitis]. Tumori. 2007 May-Jun;93(3):suppl 4-5. Italian. PMID: 17679479.

143. Schneider HJ, Rovere S, Corneli G, Croce CG, Gasco V, Rudà R, Grottoli S, Stalla GK, Soffietti R, Ghigo E, Aimaretti G. Endocrine dysfunction in patients operated on for non-pituitary intracranial tumors. Eur J Endocrinol. 2006 Oct;155(4):559-66. doi: 10.1530/eje.1.02272. PMID: 16990655.

144. Soffietti R, Cornu P, Delattre JY, Grant R, Graus F, Grisold W, Heimans J, Hildebrand J, Hoskin P, Kalljo M, Krauseneck P, Marosi C, Siegal T, Vecht C. EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force. Eur J Neurol. 2006 Jul;13(7):674-81. doi:10.1111/j.1468-1331.2006.01506.x. PMID: 16834697.

145. Soffietti R, Costanza A, Laguzzi E, Nobile M, Rudà R. Radiotherapy and chemotherapy of brain metastases. J Neurooncol. 2005 Oct;75(1):31-42. doi:10.1007/s11060-004-8096-3. PMID: 16215814.

146. Soffietti R. Chemotherapy of anaplastic oligodendroglial tumours. Expert Opin Pharmacother. 2004 Feb;5(2):295-306. doi: 10.1517/14656566.5.2.295. PMID:14996626.

147. Soffietti R, Nobile M, Rudà R, Borgognone M, Costanza A, Laguzzi E, Mutani R. Second-line treatment with carboplatin for recurrent or progressive oligodendroglial tumors after PCV (procarbazine, lomustine, and vincristine) chemotherapy: a phase II study. Cancer. 2004 Feb 15;100(4):807-13. doi:10.1002/cncr.20042. PMID: 14770438.

148. Soffietti R, Rudà R, Mutani R. Management of brain metastases. J Neurol. 2002 Oct;249(10):1357-69. doi: 10.1007/s00415-002-0870-6. PMID: 12382150.

149. Grisold W, Heimans JJ, Postma TJ, Grant R, Soffietti R; Neuro-Oncology Panel of the EFNS. The position of the neurologist in neuro-oncology. Eur J Neurol. 2002 May;9(3):201-5. doi: 10.1046/j.1468-1331.2002.00411.x. PMID:11985627.

150. Soffietti R, Rudà R, Nobile M. Metastasi cerebrali. Aspetti diagnostici e terapeutici [Cerebral metastatis. Diagnostic and therapeutic features]. Recenti Prog Med. 2000 Jun;91(6):327-31. Italian. PMID: 11512393.

151. Rudà R, Borgognone M, Benech F, Vasario E, Soffietti R. Brain metastases from unknown primary tumour: a prospective study. J Neurol. 2001 May;248(5):394-8. doi: 10.1007/s004150170180. PMID: 11437161.

152. Greco Crasto S, Soffietti R, Bradac GB, Boldorini R. Primitive cerebral melanoma: case report and review of the literature. Surg Neurol. 2001 Mar;55(3):163-8; discussion 168. doi: 10.1016/s0090-3019(01)00348-2. PMID:11311915.

153. Soffietti R, Rudà R, Bradac GB, Schiffer D. PCV chemotherapy for recurrent oligodendrogliomas and oligoastrocytomas. Neurosurgery. 1998 Nov;43(5):1066-73. doi: 10.1097/00006123-199811000-00035. PMID: 9802850.

154. Crasto S, Duca S, Davini O, Rizzo L, Pavanello IG, Avataneo T, Cirillo S, Regge D, Soffietti R. MRI diagnosis of intramedullary metastases from extra-CNS tumors. Eur Radiol. 1997;7(5):732-6. doi: 10.1007/BF02742935. PMID: 9166574.

155. Giordana MT, Cavalla P, Chiò A, Marino S, Soffietti R, Vigliani MC, Schiffer D. Prognostic factors in adult medulloblastoma. A clinico-pathologic study. Tumori. 1995 Sep-Oct;81(5):338-46. PMID: 8804450.

156. Vigliani MC, Chiò A, Pezzulo T, Soffietti R, Giordana MT, Schiffer D. Proliferating cell nuclear antigen (PCNA) in low-grade astrocytomas: its prognostic significance. Tumori. 1994 Aug 31;80(4):295-300. PMID: 7974802.

157. Bradac GB, Soffietti R, Riva A, Stura G, Sales S, Schiffer D. Selective intra-arterial chemotherapy with BCNU in recurrent malignant gliomas. Neuroradiology. 1992;34(1):73-6. doi: 10.1007/BF00588438. PMID: 1313161.

158. Schiffer D, Chiò A, Giordana MT, Migheli A, Palma L, Pollo B, Soffietti R, Tribolo A. Histologic prognostic factors in ependymoma. Childs Nerv Syst. 1991 Aug;7(4):177-82. doi: 10.1007/BF00249392. PMID: 1933913.

159. Schiffer D, Chiò A, Cravioto H, Giordana MT, Migheli A, Soffietti R, Vigliani MC. Ependymoma: internal correlations among pathological signs: the anaplastic variant. Neurosurgery. 1991 Aug;29(2):206-10. PMID: 1886658.

160. Schiffer D, Sales S, Soffietti R. Lonidamine in malignant brain tumors. Semin Oncol. 1991 Apr;18(2 Suppl 4):38-41. PMID: 2031197.

161. Vasario E, Rossi A, Sales S, Soffietti R. Utility and limits of an imaging follow-up in evaluation of response and evolution of cerebral tumors after radiotherapy. J Neurosurg Sci. 1990 Jul-Dec;34(3-4):235-7. PMID: 2098503.

162. Soffietti R. Histologic and clinical factors of prognostic significance in astrocytic gliomas. J Neurosurg Sci. 1990 Jul-Dec;34(3-4):231-4. PMID: 2098502.

163. Schiffer D, Chiò A, Giordana MT, Mauro A, Migheli A, Soffietti R, Vigliani MC. Vascular response to irradiation in malignant gliomas. J Neurooncol. 1990 Feb;8(1):73-84. doi: 10.1007/BF00182090. PMID: 2319294.

164. Giordana MT, Soffietti R, Schiffer D. Paraneoplastic opsoclonus: a neuropathologic study of two cases. Clin Neuropathol. 1989 Nov-Dec;8(6):295-300. PMID: 2559825.

165. Soffietti R, Chiò A, Giordana MT, Vasario E, Schiffer D. Prognostic factors in well-differentiated cerebral astrocytomas in the adult. Neurosurgery. 1989 May;24(5):686-92. doi: 10.1227/00006123-198905000-00005. PMID: 2716976.

166. Schiffer D, Chiò A, Giordana MT, Leone M, Soffietti R. Prognostic value of histologic factors in adult cerebral astrocytoma. Cancer. 1988 Apr 1;61(7):1386-93. doi: 10.1002/1097-0142(19880401)61:7<1386::aid-cncr2820610719>3.0.co;2-s. PMID: 3345492.

167. Schiffer D, Chiò A, Giordana MT, Novero D, Palestro G, Soffietti R, Vasario E. Primary lymphomas of the brain: a clinico-pathologic review of 37 cases. Tumori. 1987 Dec 31;73(6):585-92. PMID: 3433365.

168. Soffietti R, Sciolla R, Giordana MT, Vasario E, Schiffer D. Delayed adverse effects after irradiation of gliomas: clinicopathological analysis. J Neurooncol. 1985;3(2):187-92. doi: 10.1007/BF02228896. PMID: 4031976.

169. Soffietti R. La radioterapia delle metastasi cerebrali [Radiotherapy of cerebral metastases]. Minerva Med. 1984 May 31;75(22-23):1383-6. Italian. PMID:6203060.

170. Schiffer D, Giordana MT, Soffietti R, Sciolla R, Sannazzari GL, Vasario E. Effects of radiotherapy on the astrocytomatous areas of malignant gliomas. J Neurooncol. 1984;2(3):167-75. doi: 10.1007/BF00253268. PMID: 6502192.

171. Cibinel G, Cordero di Montezemolo L, Soffietti R, Pastore G, Sciolla R, Mosso ML, Schiffer D, Sicuro L, Madon E. Risultati a distanza nel trattamento del medulloblastoma infantile [Long-term results of the treatment of infantile medulloblastoma]. Minerva Pediatr. 1983 Feb;35(3):123-7. Italian. PMID: 6843528.

172. Schiffer D, Giordana MT, Soffietti R, Sciolla R. Histological observations on the regrowth of malignant gliomas after radiotherapy and chemotherapy. Acta Neuropathol. 1982;58(4):291-9. doi: 10.1007/BF00688612. PMID: 6297227.

173. Giordana MT, Mauro A, Soffietti R, Leone M. Association between multiple sclerosis and oligodendroglioma. Case report. Ital J Neurol Sci. 1981 Dec;2(4):403-9. PMID: 7333833.

174. Schiffer D, Giordana MT, Soffietti R, Tarenzi L. A pathologic study of malignant gliomas operated after radio- and chemotherapy. Tumori. 1981 Feb 28;67(1):13-7. PMID: 7245348.

175. Schiffer D, Giordana MT, Soffietti R, Tarenzi L, Milani R, Vasario E, Paoletti P. Radio- and chemotherapy of malignant gliomas. Pathological changes in the normal nervous tissue. Acta Neurochir (Wien). 1981;58(1-2):37-58. doi:10.1007/BF01401682. PMID: 7282460.

176. Giordana MT, Matera L, Mauro A, Soffietti R. High speed autoradiography on brain tissue sections. Basic Appl Histochem. 1981;25(2):145-8. PMID: 7271705.

177. Schiffer D, Soffietti R, Giordana MT, Tarenzi L. Tissue alterations induced by radio- and chemotherapy in brain with malignant gliomas. Acta Neuropathol Suppl. 1981;7:109-10. doi: 10.1007/978-3-642-81553-9_33. PMID: 6939213.

178. Schiffer D, Giordana MT, Soffietti R, Tarenzi L, Bertolotto A. On the nature of the so-called monstrocellular sarcoma of the brain. Neurosurgery. 1980 Apr;6(4):391-7. PMID: 6993985.

179. Schiffer D, Giordana MT, Paoletti P, Soffietti R, Tarenzi L. Pathology of human malignant gliomas after radiation and chemotherapy. Acta Neurochir (Wien). 1980;53(3-4):205-16. doi: 10.1007/BF02074793. PMID: 7424614.

180: Schiffer D, Giordana MT, Liboni W, Ravetti C, Soffietti R, Tarenzi L, Sannazzari GL, Negri GL. Chemioterapia dei tumori cerebrali: nostra esperienza sui gliomi maligni [Chemotherapy of cerebral tumours: data on malignant gliomas (author's transl)]. Riv Patol Nerv Ment. 1978 Nov-Dec;99(6):327-42. Italian.PMID: 756619.

181. Liboni W, Sicuro A, Rivadossi GA, Soffietti R. Quadri vascolari angiografici in un caso di astrocitoma anaplastico e in un caso di sarcoma monstrocellulare trattati con chemioterapici [Angiographic vascular images in a case of anaplastic astrocytoma and a case of giant cell sarcoma treated with chemotherapy (proceedings)]. Radiol Med. 1978 Jul-Aug;64(7-8):915-6. Italian. PMID: 749000.