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of Neurobiology and Molecular Genetics


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The group is currently developing two main lines of research. The first one focuses on the molecular mechanismsof different forms of short- and long-term synaptic plasticity underlying learning and memory.

The second line of research concerns the structural, molecular and cellular mechanisms of genetic diseases characterized by polyglutamine (polyQ) or polyalanine (polyA) expansions such as Huntington's disease, cleidocranial dysplasia and oculopharyngeal muscular dystrophy.

 

Group’s ECR Sectors:

LS2_10 - Bioinformatics

LS2_6 - Molecular genetics, reverse genetics and RNAi

LS5_11 - Neurological disorders (e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease)

LS5_2 - Molecular and cellular neuroscience

 

Publications

Fiumara, Ferdinando, Rajasethupathy, Priyamvada, Antonov, Igor, Kosmidis, Stylianos, Sossin, Wayne S , Kandel, Eric R (2015)
MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream Targets.
https://iris.unito.it/handle/2318/1523624

Pelassa I, Cora', D, Cesano F, Monje FJ, Montarolo PG, Fiumara F (2014)
Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction.
https://iris.unito.it/handle/2318/147060

Giachello CN, Fiumara F, Giacomini C, Corradi A, Milanese C, Ghirardi M, Benfenati F, Montarolo PG (2010)
MAPK/Erk-dependent phosphorylation of synapsin mediates formation of functional synapses and short-term homosynaptic plasticity.
https://iris.unito.it/handle/2318/73798

Ferdinando Fiumara, Luana Fioriti, Eric R Kandel, Wayne A Hendrickson (2010)
Essential role of coiled coils for aggregation and activity of Q/N-rich prions and polyQ proteins.
https://iris.unito.it/handle/2318/81776

Rajasethupathy P, Fiumara F, Sheridan R, Betel D, Puthanveettil SV, Russo JJ, Sander C, Tuschl T, Kandel E (2009)
Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.
https://iris.unito.it/handle/2318/69529

Paolo Massobrio, Mariateresa Tedesco, Carlo Giachello, Mirella Ghirardi, Ferdinando Fiumara, Sergio Martinoia (2009)
Helix neuronal ensembles with controlled cell type composition and placement develop functional polysynaptic circuits on Micro-Electrode Arrays.
https://iris.unito.it/handle/2318/70352

Milanese C, Giachello C, Fiumara F, Bizzoca A, Gennarini G, Montarolo PG, Ghirardi M (2009)
Characterization and role of Helix contactin-related proteins in cultured Helix pomatia neurons.
https://iris.unito.it/handle/2318/56983

C MILANESE, F FIUMARA, A BIZZOCA, C GIACHELLO, G LEITINGER, G GENNARINI, P G MONTAROLO, M GHIRARDI (2008)
F3/contactin-related proteins in Helix pomatia nervous tissue (HCRPs): Distribution and function in neurite growth and neurotransmitter release.
https://iris.unito.it/handle/2318/37077

FIUMARA F, MILANESE C, CORRADI AM, GIOVEDÌ S, LEITINGER G, MENEGON A, MONTAROLO PG, BENFENATI F, GHIRARDI M (2007)
Phosphorylation of synapsin domain A is required for post-tetanic potentiation.
https://iris.unito.it/handle/2318/42596

CLAVEROL-TINTURÉ E, GHIRARDI M, FIUMARA F, ROSELL X, CABESTANY J (2005)
Multielectrode arrays with elastomeric microstructured overlays for extracellular recordings from patterned neurons.
https://iris.unito.it/handle/2318/32361

FIUMARA F, LEITINGER G, MILANESE C, MONTAROLO PG, GHIRARDI M (2005)
In vitro formation and activity-dependent plasticity of synapses between Helix neurons involved in the neural control of feeding and withdrawal behaviors.
https://iris.unito.it/handle/2318/43370

GHIRARDI M, BENFENATI F, GIOVED S, FIUMARA F, MILANESE C, MONTAROLO PG (2004)
Inhibition of neurotransmitter release by a nonphysiological target requires protein synthesis and involves cAMP-dependent and mitogen-activated protein kinases.
https://iris.unito.it/handle/2318/37927

CASADIO A, FIUMARA F, SONETTI D, MONTAROLO P G, GHIRARDI M (2004)
Distribution of sensorin immunoreactivity in the central nervous system of Helix pomatia: functional aspects.
https://iris.unito.it/handle/2318/38628

FIUMARA F, GIOVED S, MENEGON A, MILANESE C, MERLO D, MONTAROLO P, VALTORTA F, BENFENATI F, FIUMARA F, GHIRARDI M (2004)
Phosphorylation by cAMP-dependent protein kinase is essential for synapsin-induced enhancement of neurotransmitter release in invertebrate neurons.
https://iris.unito.it/handle/2318/41266

GHIRARDI M, NARETTO G, FIUMARA F, VITIELLO F, MONTAROLO PG (2001)
Target-dependent modulation of neurotransmitter release in cultured Helix neurons involves adhesion molecules.
https://iris.unito.it/handle/2318/36789

FIUMARA F, ONOFRI F, BENFENATI F, MONTAROLO P, GHIRARDI M (2001)
Intracellular injection of synapsin I induces neurotransmitter release in C1 neurons of Helix pomatia contacting a wrong target.
https://iris.unito.it/handle/2318/41653

Last update: 02/09/2015 23:23
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