of Neurobiology and Molecular Genetics
The group is currently developing two main lines of research. The first one focuses on the molecular mechanismsof different forms of short- and long-term synaptic plasticity underlying learning and memory.
The second line of research concerns the structural, molecular and cellular mechanisms of genetic diseases characterized by polyglutamine (polyQ) or polyalanine (polyA) expansions such as Huntington's disease, cleidocranial dysplasia and oculopharyngeal muscular dystrophy.
Group’s ECR Sectors:
LS2_10 - Bioinformatics
LS2_6 - Molecular genetics, reverse genetics and RNAi
LS5_11 - Neurological disorders (e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease)
LS5_2 - Molecular and cellular neuroscience
Fiumara, Ferdinando, Rajasethupathy, Priyamvada, Antonov, Igor, Kosmidis, Stylianos, Sossin, Wayne S , Kandel, Eric R (2015)
MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream Targets.
Pelassa I, Cora', D, Cesano F, Monje FJ, Montarolo PG, Fiumara F (2014)
Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction.
Giachello CN, Fiumara F, Giacomini C, Corradi A, Milanese C, Ghirardi M, Benfenati F, Montarolo PG (2010)
MAPK/Erk-dependent phosphorylation of synapsin mediates formation of functional synapses and short-term homosynaptic plasticity.
Ferdinando Fiumara, Luana Fioriti, Eric R Kandel, Wayne A Hendrickson (2010)
Essential role of coiled coils for aggregation and activity of Q/N-rich prions and polyQ proteins.
Rajasethupathy P, Fiumara F, Sheridan R, Betel D, Puthanveettil SV, Russo JJ, Sander C, Tuschl T, Kandel E (2009)
Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.
Paolo Massobrio, Mariateresa Tedesco, Carlo Giachello, Mirella Ghirardi, Ferdinando Fiumara, Sergio Martinoia (2009)
Helix neuronal ensembles with controlled cell type composition and placement develop functional polysynaptic circuits on Micro-Electrode Arrays.
Milanese C, Giachello C, Fiumara F, Bizzoca A, Gennarini G, Montarolo PG, Ghirardi M (2009)
Characterization and role of Helix contactin-related proteins in cultured Helix pomatia neurons.
C MILANESE, F FIUMARA, A BIZZOCA, C GIACHELLO, G LEITINGER, G GENNARINI, P G MONTAROLO, M GHIRARDI (2008)
F3/contactin-related proteins in Helix pomatia nervous tissue (HCRPs): Distribution and function in neurite growth and neurotransmitter release.
FIUMARA F, MILANESE C, CORRADI AM, GIOVEDÌ S, LEITINGER G, MENEGON A, MONTAROLO PG, BENFENATI F, GHIRARDI M (2007)
Phosphorylation of synapsin domain A is required for post-tetanic potentiation.
CLAVEROL-TINTURÉ E, GHIRARDI M, FIUMARA F, ROSELL X, CABESTANY J (2005)
Multielectrode arrays with elastomeric microstructured overlays for extracellular recordings from patterned neurons.
FIUMARA F, LEITINGER G, MILANESE C, MONTAROLO PG, GHIRARDI M (2005)
In vitro formation and activity-dependent plasticity of synapses between Helix neurons involved in the neural control of feeding and withdrawal behaviors.
GHIRARDI M, BENFENATI F, GIOVED S, FIUMARA F, MILANESE C, MONTAROLO PG (2004)
Inhibition of neurotransmitter release by a nonphysiological target requires protein synthesis and involves cAMP-dependent and mitogen-activated protein kinases.
CASADIO A, FIUMARA F, SONETTI D, MONTAROLO P G, GHIRARDI M (2004)
Distribution of sensorin immunoreactivity in the central nervous system of Helix pomatia: functional aspects.
FIUMARA F, GIOVED S, MENEGON A, MILANESE C, MERLO D, MONTAROLO P, VALTORTA F, BENFENATI F, FIUMARA F, GHIRARDI M (2004)
Phosphorylation by cAMP-dependent protein kinase is essential for synapsin-induced enhancement of neurotransmitter release in invertebrate neurons.
GHIRARDI M, NARETTO G, FIUMARA F, VITIELLO F, MONTAROLO PG (2001)
Target-dependent modulation of neurotransmitter release in cultured Helix neurons involves adhesion molecules.
FIUMARA F, ONOFRI F, BENFENATI F, MONTAROLO P, GHIRARDI M (2001)
Intracellular injection of synapsin I induces neurotransmitter release in C1 neurons of Helix pomatia contacting a wrong target.