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Placebo Responses Mapping




The activity consists in the identification and biochemical, anatomical and physiological mapping of placebo responses in different pathological conditions and in physical and cognitive performance. Currently, the following conditions are studied:

  • hypoxia and hypothermia at the laboratories of High Altitude Medicine and Physiology (Breuil-Cervinia and Zermatt)

  • physical performance and pain at the laboratories of Corso Raffaello 30 in Turin

  • pain and movement disorders at the laboratories of Via Cherasco 15 in Turin

  • aphasia at Fondazione Molo in Via della Rocca 24bis in Turin


Group’s ECR Sectors:

LS4_1 - Organ physiology and pathophysiology

LS5_1 - Neuroanatomy and neurophysiology

LS5_11 - Neurological disorders (e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease)

LS5_3 - Neurochemistry and neuropharmacology

LS5_5 - Mechanisms of pain



Selected publications

Benedetti F, Amanzio M, Maggi G (1995) Potentiation of placebo analgesia by proglumide. Lancet 346: 1231. 

Benedetti F, Colloca L., Torre E, Lanotte M, Melcarne A, Pesare M, Bergamasco B, Lopiano L (2004) Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus. Nature Neurosci, 7: 587-588.

Colloca L, Lopiano L, Lanotte M, Benedetti F (2004) Overt versus covert treatment for pain, anxiety and Parkinson’s disease. Lancet Neurol 3: 679-684.

Colloca L, Benedetti F (2005) Placebos and painkillers: is mind as real as matter? Nature Rev Neurosci 6: 545-552.

Finniss DG, Miller F, Kaptchuk T, Benedetti F (2010) Biological, clinical, and ethical advances of placebo effects. Lancet, 375: 686-695.

Benedetti F, Amanzio M, Rosato R, Blanchard C (2011) Non-opioid placebo analgesia is mediated by CB1 cannabinoid receptors. Nature Med, 17: 1228-1230.

Carlino E, Frisaldi E, Benedetti F (2014) Pain and the context. Nature Rev Rheum, 10: 348-355.

Benedetti F, Carlino E, Piedimonte A (2016) Placebo, nocebo, Hawthorne effects and the increasing uncertainty in clinical trials. Lancet Neurol, 15, 736-747.

Benedetti F (2010) The patient’s brain: The neuroscience behind the doctor-patient relationshipOxford: Oxford University Press.

Benedetti F (2020) Placebo effects. 3rd Edition, Oxford: OxfordUniversity Press.


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