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Mood Disorders



Our clinical research is concerned with the complexity of diagnosis and treatment of mood disorders. In particular, the research group deals with the problem of Bipolar Disorder’s course, with specific attention to atypical and unstable manifestations; seasonality; juvenile onset; early detection; psychiatric comorbidities (both Axis I - specifically with anxiety disorders - and Axis II); medical comorbidity (especially with the metabolic syndrome); behavioral aspects; quality of life.

From the pharmacotherapeutic viewpoint we focus on the pharmacological treatment of comorbidities and on the management of long-term treatment in its prognostic implications, payng special attention to tolerability.

With regard to the psychotherapeutic aspects, the Group deals with the effectiveness of psychoeducation for bipolar patients. We also focus on the study of treatment resistant Major Depression: its clinical and prognostic aspects, comorbidity with anxiety disorders and somatoform disorders, the psychopharmacological treatment and the use of short dynamic psychotherapy.

Both Major Depression and bipolar disorder are subject to important research, focusing on diagnosis, treatment and management of psychiatric disorders during peri-conceptional period, pregnancy and postpartum.

We study the biological markers of psychiatric disorders, in collaboration with the University of Brescia - IRCCS Fatebenefratelli, Unit of Neuropsychopharmacology.


Group’s ERC Sectors:

 LS5_12 - Psychiatric disorders (e.g. schizophrenia, autism, Tourette’s syndrome, obsessive compulsive disorder, depression, bipolar disorder, attention deficit hyperactivity disorder

 LS7_3 - Pharmacology, pharmacogenomics, drug discovery and design, drug therapy


Albert U, De Cori D, Aguglia A, Barbaro F, Lanfranco F, Bogetto F, Maina G. (2015) Effects of maintenance lithium treatment on serum parathyroid hormone and calcium levels: a retrospective longitudinal naturalistic study. Neuropsychiatric disease and treatment 11 1785-91 [DOI  PMID]

Rosso G, Cattaneo A, Zanardini R, Gennarelli M, Maina G, Bocchio-Chiavetto L. (2015) Glucose metabolism alterations in patients with bipolar disorder. Journal of affective disorders 184 293-8 [DOI  PMID]

Verne E, Bruno M, Miola M, Maina G, Bianco C, Cochis A, Rimondini L. (2015) Composite bone cements loaded with a bioactive and ferrimagnetic glass-ceramic: Leaching, bioactivity and cytocompatibility. Materials science & engineering. C, Materials for biological applications 53 95-103 [DOI  PMID]

Browne LB, Menkir Z, Kahi V, Maina G, Asnakew S, Tubman M, Elyas HZ, Nigatu A, Dak D, Maung UA, Nakao JH, Bilukha O, Shahpar C. (2015) Notes from the field: hepatitis E outbreak among refugees from South Sudan - Gambella, Ethiopia, April 2014-January 2015. MMWR. Morbidity and mortality weekly report 64(19) 537 [PMID]

Albert U, Maina G, Aguglia A, Vitalucci A, Bogetto F, Fronda C, Ducati A, Lanotte M. (2015) Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study. BMC psychiatry 15 64 [DOI  PMID]

Nesvadbova M, Crosera M, Maina G, Larese Filon F. (2015) Povidone iodine skin absorption: an ex-vivo study. Toxicology letters 235(3) 155-60 [DOI  PMID]

Bianco C, Kezic S, Crosera M, Svetlicic V, Segota S, Maina G, Romano C, Larese F, Adami G. (2015) In vitro percutaneous penetration and characterization of silver from silver-containing textiles. International journal of nanomedicine 10 1899-908 [DOI  PMID]

Fagiolini A, Brugnoli R, Di Sciascio G, De Filippis S, Maina G. (2015) Switching antipsychotic medication to aripiprazole: position paper by a panel of Italian psychiatrists. Expert opinion on pharmacotherapy 16(5) 727-37 [DOI  PMID]

Congiu C, Minelli A, Bonvicini C, Bortolomasi M, Sartori R, Maj C, Scassellati C, Maina G, Trabucchi L, Segala M, Gennarelli M. (2015) The role of the potassium channel gene KCNK2 in major depressive disorder. Psychiatry research 225(3) 489-92 [DOI  PMID]

Albert U, De Cori D, Aguglia A, Barbaro F, Bogetto F, Maina G. (2015) Increased uric acid levels in bipolar disorder subjects during different phases of illness. Journal of affective disorders 173 170-5 [DOI  PMID]

Mutuku MW, Dweni CK, Mwangi M, Kinuthia JM, Mwangi IN, Maina GM, Agola LE, Zhang SM, Maranga R, Loker ES, Mkoji GM. (2014) Field-derived Schistosoma mansoni and Biomphalaria pfeifferi in Kenya: a compatible association characterized by lack of strong local adaptation, and presence of some snails able to persistently produce cercariae for over a year. Parasites & vectors 7 533 [DOI  PMID]

Lelo AE, Mburu DN, Magoma GN, Mungai BN, Kihara JH, Mwangi IN, Maina GM, Kinuthia JM, Mutuku MW, Loker ES, Mkoji GM, Steinauer ML. (2014) No apparent reduction in schistosome burden or genetic diversity following four years of school-based mass drug administration in mwea, central kenya, a heavy transmission area. PLoS neglected tropical diseases 8(10) e3221 [DOI  PMID]

Miola M, Bruno M, Maina G, Fucale G, Lucchetta G, Verne E. (2014) Antibiotic-free composite bone cements with antibacterial and bioactive properties. A preliminary study. Materials science & engineering. C, Materials for biological applications 43 65-75 [DOI  PMID]

Andresen E, Bilukha OO, Menkir Z, Gayford M, Kavosa M, Wtsadik M, Maina G, Gose M, Nyagucha I, Shahpar C. (2014) Notes from the field: malnutrition and elevated mortality among refugees from South Sudan - Ethiopia, June-July 2014. MMWR. Morbidity and mortality weekly report 63(32) 700-1 [PMID]

Navarro-Colorado C, Mahamud A, Burton A, Haskew C, Maina GK, Wagacha JB, Ahmed JA, Shetty S, Cookson S, Goodson JL, Schilperoord M, Spiegel P. (2014) Measles outbreak response among adolescent and adult Somali refugees displaced by famine in Kenya and Ethiopia, 2011. The Journal of infectious diseases 210(12) 1863-70 [DOI  PMID]

Dianzani C, Zara GP, Maina G, Pettazzoni P, Pizzimenti S, Rossi F, Gigliotti CL, Ciamporcero ES, Daga M, Barrera G. (2014) Drug delivery nanoparticles in skin cancers. BioMed research international 2014 895986 [DOI  PMID]

Caresano C, Di Sciascio G, Fagiolini A, Maina G, Perugi G, Ripellino C, Vampini C. (2014) Cost-effectiveness of asenapine in the treatment of patients with bipolar I disorder with mixed episodes in an Italian context. Advances in therapy 31(8) 873-90 [DOI  PMID]

Maina G, Ripellino C. (2014) The risk of metabolic disorders in patients treated with asenapine or olanzapine: a study conducted on real-world data in Italy and Spain. Expert opinion on drug safety 13(9) 1149-54 [DOI  PMID]

Caneparo A, Massucco P, Vaira M, Maina G, Giovale E, Coggiola M, Cinquegrana A, Robella M, De Simone M. (2014) Contamination risk for operators performing semi-closed HIPEC procedure using cisplatin. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 40(8) 925-9 [DOI  PMID]

Bianco C, Adami G, Crosera M, Larese F, Casarin S, Castagnoli C, Stella M, Maina G. (2014) Silver percutaneous absorption after exposure to silver nanoparticles: a comparison study of three human skin graft samples used for clinical applications. Burns : journal of the International Society for Burn Injuries 40(7) 1390-6 [DOI  PMID]

Miola M, Brovarone CV, Maina G, Rossi F, Bergandi L, Ghigo D, Saracino S, Maggiora M, Canuto RA, Muzio G, Verne E. (2014) In vitro study of manganese-doped bioactive glasses for bone regeneration. Materials science & engineering. C, Materials for biological applications 38 107-18 [DOI  PMID]

Albert U, De Cori D, Bogetto F, Maina G. (2014) Hypomania associated with adjunctive low-dose aripiprazole: two case reports and a brief review of the literature. Psychiatria Danubina 26(1) 80-3 [PMID]

Albert U, De Cori D, Blengino G, Bogetto F, Maina G. (2014) [Lithium treatment and potential long-term side effects: a systematic review of the literature]. Rivista di psichiatria 49(1) 12-21 [DOI  PMID]

Maina G, Rosso G, Aguglia A, Bogetto F. (2014) Recurrence rates of bipolar disorder during the postpartum period: a study on 276 medication-free Italian women. Archives of women's mental health 17(5) 367-72 [DOI  PMID]

Mencacci C, Aguglia E, Biggio G, Cappellari L, Di Sciascio G, Fagiolini A, Maina G, Tortorella A, Katz P, Ripellino C. (2013) C-QUALITY: cost and quality-of-life pharmacoeconomic analysis of antidepressants used in major depressive disorder in the regional Italian settings of Veneto and Sardinia. ClinicoEconomics and outcomes research : CEOR 5 611-21 [DOI  PMID]

Steinauer ML, Christie MR, Blouin MS, Agola LE, Mwangi IN, Maina GM, Mutuku MW, Kinuthia JM, Mkoji GM, Loker ES. (2013) Non-invasive sampling of schistosomes from humans requires correcting for family structure. PLoS neglected tropical diseases 7(9) e2456 [DOI  PMID]

Catalano F, Mariano F, Maina G, Bianco C, Nuzzo J, Stella M. (2013) An unusual case of extensive self-inflicted cement burn. Annals of burns and fire disasters 26(1) 40-3 [PMID]

Minelli A, Maffioletti E, Bortolomasi M, Conca A, Zanardini R, Rillosi L, Abate M, Giacopuzzi M, Maina G, Gennarelli M, Bocchio-Chiavetto L. (2014) Association between baseline serum vascular endothelial growth factor levels and response to electroconvulsive therapy. Acta psychiatrica Scandinavica 129(6) 461-6 [DOI  PMID]

Mencacci C, Aguglia E, Biggio G, Cappellari L, Di Sciascio G, Fagiolini A, Maina G, Tortorella A, Katz P, Ripellino C. (2013) C-QUALITY: cost and quality-of-life pharmacoeconomic analysis of antidepressants in major depressive disorder in Italy. Advances in therapy 30(7) 697-712 [DOI  PMID]

Albert U, De Cori D, Aguglia A, Barbaro F, Lanfranco F, Bogetto F, Maina G. (2013) Lithium-associated hyperparathyroidism and hypercalcaemia: a case-control cross-sectional study. Journal of affective disorders 151(2) 786-90 [DOI  PMID]

Gillio-Tos A, De Marco L, Carozzi FM, Del Mistro A, Girlando S, Burroni E, Frayle-Salamanca H, Giorgi Rossi P, Pierotti P, Ronco G. (2013) Clinical impact of the analytical specificity of the hybrid capture 2 test: data from the New Technologies for Cervical Cancer (NTCC) study. Journal of clinical microbiology 51(9) 2901-7 [DOI  PMID]

Vitalucci A, Coppola I, Mirra M, Maina G, Bogetto F. (2013) [Brain stimulation therapies for treatment-resistant depression]. Rivista di psichiatria 48(3) 175-81 [DOI  PMID]

Maina G, Sutankayo L, Chorney R, Caine V. (2014) Living with and teaching about HIV: engaging nursing students through body mapping. Nurse education today 34(4) 643-7 [DOI  PMID]

Maina G. (2012) [Psychosocial factors and cardiovascular diseases: the neuroendocrine pathways]. Giornale italiano di medicina del lavoro ed ergonomia 34(3 Suppl) 170-3 [PMID]

Maina G, Sorasio D, Rossi F, Zito D, Perrelli E, Baracco A. (2012) [Work-related musculo-skeletal disorders in apiculture: a biomechanical approach to the risk assessment]. Giornale italiano di medicina del lavoro ed ergonomia 34(3 Suppl) 119-21 [PMID]

Maina G, Bechon E, Rigardetto S, Salvi V. (2013) General medical conditions are associated with delay to treatment in patients with bipolar disorder. Psychosomatics 54(5) 437-42 [DOI  PMID]

Rosso G, Martini B, Maina G. (2013) Brief dynamic therapy and depression severity: a single-blind, randomized study. Journal of affective disorders 147(1-3) 101-6 [DOI  PMID]

Albert U, Aguglia A, Chiarle A, Bogetto F, Maina G. (2013) Metabolic syndrome and obsessive-compulsive disorder: a naturalistic Italian study. General hospital psychiatry 35(2) 154-9 [DOI  PMID]

Rosso G, Bertetto N, Coppola I, Maina G. (2012) [Mood stabilizers in the treatment of bipolar disorder mixed states]. Rivista di psichiatria 47(4) 281-93 [DOI  PMID]

Albert U, Barbaro F, Aguglia A, Maina G, Bogetto F. (2012) [Combined treatments in obsessive-compulsive disorder: current knowledge and future prospects]. Rivista di psichiatria 47(4) 255-68 [DOI  PMID]

Larese Filon F, Crosera M, Timeus E, Adami G, Bovenzi M, Ponti J, Maina G. (2013) Human skin penetration of cobalt nanoparticles through intact and damaged skin. Toxicology in vitro : an international journal published in association with BIBRA 27(1) 121-7 [DOI  PMID]

Albert U, Aguglia A, Bogetto F, Cieri L, Daniele M, Maina G, Necci R, Parena A, Salvati L, Tundo A. (2012) Effectiveness of cognitive-behavioral therapy addition to pharmacotherapy in resistant obsessive-compulsive disorder: a multicenter study. Psychotherapy and psychosomatics 81(6) 383-5 [DOI  PMID]

Rosso G, Bechon E, Bogetto F, Maina G. (2012) [OCD during pregnancy and post partum]. Rivista di psichiatria 47(3) 200-4 [DOI  PMID]

Rosso G, Albert U, Asinari GF, Bogetto F, Maina G. (2012) Stressful life events and obsessive-compulsive disorder: clinical features and symptom dimensions. Psychiatry research 197(3) 259-64 [DOI  PMID]

D'Ambrosio V, Salvi V, Bogetto F, Maina G. (2012) Serum lipids, metabolic syndrome and lifetime suicide attempts in patients with bipolar disorder. Progress in neuro-psychopharmacology & biological psychiatry 37(1) 136-40 [DOI  PMID]

Salvi V, D'Ambrosio V, Bogetto F, Maina G. (2012) Metabolic syndrome in Italian patients with bipolar disorder: a 2-year follow-up study. Journal of affective disorders 136(3) 599-603 [DOI  PMID]

Maina G, Bovenzi M, Palmas A, Rossi F, Filon FL. (2012) Psychosocial environment and health: methodological variability of the salivary cortisol measurements. Toxicology letters 213(1) 21-6 [DOI  PMID]

Rosso G, Rigardetto S, Bogetto F, Maina G. (2012) A randomized, single-blind, comparison of duloxetine with bupropion in the treatment of SSRI-resistant major depression. Journal of affective disorders 136(1-2) 172-6 [DOI  PMID]

Novajra G, Vitale-Brovarone C, Knowles JC, Maina G, Aina V, Ghigo D, Bergandi L. (2011) Effects of TiO2-containing phosphate glasses on solubility and in vitro biocompatibility. Journal of biomedical materials research. Part A 99(2) 295-306 [DOI  PMID]

Salvi V, Cat Berro A, Bechon E, Bogetto F, Maina G. (2011) [Lithium and anticonvulsants in the treatment of mania and in the prophylaxis of recurrences]. Rivista di psichiatria 46(3) 172-81 [DOI  PMID]

Maina G, Cafaro R, Sorasio D, Rossi F. (2011) [Unusual work schedule: mathematical and pharmacokinetic models to adjust the occupational exposure limit of the chemical agents]. Giornale italiano di medicina del lavoro ed ergonomia 33(3 Suppl) 28-30 [PMID]

Filon FL, Crosera M, Adami G, Bovenzi M, Rossi F, Maina G. (2011) Human skin penetration of gold nanoparticles through intact and damaged skin. Nanotoxicology 5(4) 493-501 [DOI  PMID]

Ferraris S, Spriano S, Pan G, Venturello A, Bianchi CL, Chiesa R, Faga MG, Maina G, Verne E. (2011) Surface modification of Ti-6Al-4V alloy for biomineralization and specific biological response: Part I, inorganic modification. Journal of materials science. Materials in medicine 22(3) 533-45 [DOI  PMID]

Salvi V, D'Ambrosio V, Rosso G, Bogetto F, Maina G. (2011) Age-specific prevalence of metabolic syndrome in Italian patients with bipolar disorder. Psychiatry and clinical neurosciences 65(1) 47-54 [DOI  PMID]

De Fazio P, Girardi P, Maina G, Mauri MC, Mauri M, Monteleone P, Perini GI, Perugi G, Rossi A. (2010) Aripiprazole in acute mania and long-term treatment of bipolar disorder: a critical review by an Italian working group. Clinical drug investigation 30(12) 827-41 [DOI  PMID]

Maina G, Bovenzi M, Palmas A, Prodi A, Filon FL. (2011) Job strain, effort-reward imbalance and ambulatory blood pressure: results of a cross-sectional study in call handler operators. International archives of occupational and environmental health 84(4) 383-91 [DOI  PMID]

Quaglino GP, Ghislieri C, Colombo L, D'Orso MI, Maina G, Turbati M, Fubini E, Piccardo C, Re A, Spano M, Iavicoli S, Cesana GC. (2010) [Well-being in call centres: a multidisciplinary approach to research and evaluation]. La Medicina del lavoro 101(3) 169-88 [PMID]

Aguglia A, Salvi V, Maina G, Rossetto I, Aguglia E. (2011) Fibromyalgia syndrome and depressive symptoms: comorbidity and clinical correlates. Journal of affective disorders 128(3) 262-6 [DOI  PMID]

Maina G, Rosso G, Rigardetto S, Chiado Piat S, Bogetto F. (2010) No effect of adding brief dynamic therapy to pharmacotherapy in the treatment of obsessive-compulsive disorder with concurrent major depression. Psychotherapy and psychosomatics 79(5) 295-302 [DOI  PMID]

D'Ambrosio V, Albert U, Bogetto F, Maina G. (2010) Obsessive-compulsive disorder and cyclothymic temperament: an exploration of clinical features. Journal of affective disorders 127(1-3) 295-9 [DOI  PMID]

Albert U, Bogetto F, Maina G, Saracco P, Brunatto C, Mataix-Cols D. (2010) Family accommodation in obsessive-compulsive disorder: Relation to symptom dimensions, clinical and family characteristics. Psychiatry research 179(2) 204-11 [DOI  PMID]

Hanelt B, Mwangi IN, Kinuthia JM, Maina GM, Agola LE, Mutuku MW, Steinauer ML, Agwanda BR, Kigo L, Mungai BN, Loker ES, Mkoji GM. (2010) Schistosomes of small mammals from the Lake Victoria Basin, Kenya: new species, familiar species, and implications for schistosomiasis control. Parasitology 137(7) 1109-18 [DOI  PMID]

Maina G, D'Ambrosio V, Aguglia A, Paschetta E, Salvi V, Bogetto F. (2010) [Bipolar disorders and metabolic syndrome: a clinical study in 185 patients]. Rivista di psichiatria 45(1) 34-40 [PMID]

Balagna C, Vitale-Brovarone C, Miola M, Verne E, Canuto RA, Saracino S, Muzio G, Fucale G, Maina G. (2011) Biocompatibility and antibacterial effect of silver doped 3D-glass-ceramic scaffolds for bone grafting. Journal of biomaterials applications 25(6) 595-617 [DOI  PMID]

Albert U, Maina G, Bogetto F, Chiarle A, Mataix-Cols D. (2010) Clinical predictors of health-related quality of life in obsessive-compulsive disorder. Comprehensive psychiatry 51(2) 193-200 [DOI  PMID]

Monteleone P, Bifulco M, Maina G, Tortorella A, Gazzerro P, Proto MC, Di Filippo C, Monteleone F, Canestrelli B, Buonerba G, Bogetto F, Maj M. (2010) Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. Pharmacological research : the official journal of the Italian Pharmacological Society 61(5) 400-4 [DOI  PMID]

Last update: 24/08/2015 13:57
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