Vai al contenuto principale
Group picture

Neuroendocrinology

Staff

Picture

Activity

Hormones are among the most important environmental factors for the development, differentiation and functioning of the nervous system. In particular, our research group is interested in the interactions between steroid hormones, neural circuits and behaviours dependent on steroids, such as sexual behaviour and the behavioural response to stress.

Explaining these interactions can be crucial to understand the causes that lead to some behavioral disorders (anorexia, depression) or neurodegenerative diseases (Parkinson's, multiple sclerosis) in which there are evident gender differences, such that one sex has a greater prevalence or severity of the disease than the other.

In addition, a minimum alteration of hormone balances - determined by exposure to chemical compounds able to interact with their receptors - can induce harmful effects on the behavior and physiology of animals and humans.

The experimental studies in this field are useful to understanding what threshold values ​​may be acceptable and if certain dysfunctions can be caused by exposure to these environmental factors.

Our main research lines currently include:

- The role of androgens and estrogens in the differentiation of the brain circuits involved in controlling the reproduction and social behavior.

- The role of neurosteroids and some neuropeptides in affective disorders, in order to understand whether gender differences that occur in these diseases may have a basis related to the effects of endogenous neurosteroids.

- Short- and long-term effects of neurosteroids on adult sexual neurogenesis.

- Effects of Endocrine disruptors (xenoestrogen and xenoandrogen) exposure on the differentiation of brain circuits that control reproduction and feeding behavior.

 

Group’s ECR Sectors:

LS4_3 - Endocrinology

LS4_5 - Metabolism, biological basis of metabolism related disorders

LS5_1 - Neuroanatomy and neurophysiology

Publications

B. Bonaldo, L. Gioiosa, GC. Panzica, M. Marraudino (2022) Exposure to either bisphenol A or S represents a risk for crucial behaviors for pup survival, such as spontaneous maternal behavior in mice. Neuroendocrinology. https://doi.org/10.1159/000526074 

Marraudino M, Bonaldo B, Vitiello B, Bergui GC, Panzica G. (2022) Sexual Differences in Internet Gaming Disorder (IGD): From Psychological Features to Neuroanatomical Networks J Clin Med. 2022 Feb 16;11(4):1018. doi: 10.3390/jcm11041018.

Panzica G, Melcangi RC. Neuroactive steroids: From basic research to clinical use (2022) J Neuroendocrinol. Feb;34(2):e13102. doi: 10.1111/jne.13102.

Grassi D, Marraudino M, Garcia-Segura LM, Panzica GC (2022) The hypothalamic paraventricular nucleus as a central hub for the estrogenic modulation of neuroendocrine function and behavior Front Neuroendocrinol. Jan 5;65:100974. doi: 10.1016/j.yfrne.2021.100974.

Aspesi D, Farinetti A, Marraudino M, Morgan GSK, Marzola E, Abbate-Daga G, Gotti S (2021) Maternal separation alters the reward system of activity-based anorexia rats. Psychoneuroendocrinology. Nov;133:105393. doi: 10.1016/j.psyneuen.2021.105393.

Perga S, Montarolo F, Martire S, Bonaldo B, Bono G, Bertolo J, Magliozzi R, Bertolotto A.(2021) Overexpression of the ubiquitin-editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving from systemic to central nervous system inflammation. Brain Pathol. Mar;31(2):283-296. doi: 10.1111/bpa.12906. Epub 2020 Nov 18. PMID: 33051914

Bonaldo B., Casile A., Bettarelli M., GottiS., Panzica G., Marraudino M. (2021) Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)European Journal of Histochemistry 65(s1):3272. doi: 10.4081/ejh.2021.3272.

Marilena Marraudino, Giovanna Ponti, Chantal Moussu, Alice Farinetti, Elisabetta Macchi, Paolo Accornero, Stefano Gotti, Paloma Collado, Matthieu Keller, Giancarlo Panzica (2021) Early Postnatal Genistein Administration Affects Mice Metabolism and Reproductionin a Sexually Dimorphic Way. Metabolites11, 449. DOI: 10.3390/metabo11070449

Marraudino M, Bo E, Carlini E, Farinetti A, Ponti G, Zanella I, Di Lorenzo D, Panzica GC, Gotti S. Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors. Metabolites. 2021 Jun 9;11(6):368. doi: 10.3390/metabo11060368. PMID: 34207679; PMCID: PMC8228876.

Collantoni E, Tenconi E, Solmi M, Meneguzzo P, Marzola E, D'Agata F, Gotti S, Daga GA, Manara R, Favaro A. Hippocampal volumes in anorexia nervosa at different stages of the disorder. Eur Eat Disord Rev. 2021 Jan;29(1):112-122. doi: 10.1002/erv.2806. Epub 2020 Nov 13. PMID: 33186479.

Llorente R, Marraudino M, Carrillo B, Bonaldo B, Simon-Areces J, Abellanas-Pérez P, Rivero-Aguilar M, Fernandez-Garcia JM, Pinos H, Garcia-Segura LM, Collado P, Grassi D (2020) G Protein-Coupled Estrogen Receptor Immunoreactivity Fluctuates During the Estrous Cycle and Show Sex Differences in the Amygdala and Dorsal Hippocampus.  Front Endocrinol (Lausanne). 2020 Aug 7;11:537. doi: 10.3389/fendo.2020.00537.

Marraudino M, Carrillo B, Bonaldo B, Llorente R, Campioli E, Garate I, Pinos H, Garcia-Segura LM, Collado P, Grassi D (2020) G protein-couple destrogen receptor immunoreactivity in the rat hypothalamus is widely distributed in neurons, astrocytes and oligodendrocytes, fluctuates during the estrouscycle and is sexually dimorphic. Neuroendocrinology. 2020 Jun 22. DOI 10.1159/000509583.

Panzica G., Melacangi R.C. (guest editors) Steroids and Nervous System (special issue) J. Neuroendocrinology 32 (1).

Panzica GC, Michetti F, Tayebati SK, De Giorgio R, Mariotti R, Pacini A, Quartu M 2020 A bridge among history and new multidisciplinary approaches: the role of G.I.S.N. in the field of neuromorphology. European Journal of Histochemistry 64, suppl.3: 1 https://doi.org/10.4081/ejh.2020.3200

Briguglio M, Vitale JA, Galentino R, Banfi G, Zanaboni Dina C, Bona A, Panzica GC, Porta M, Dell'Osso B, Glick ID. 2020 Healthy Eating, Physical Activity, and Sleep Hygiene (HEPAS) as the Winning Triad for Sustaining Physical and Mental Health in Patients at Risk for or with Neuropsychiatric Disorders: Considerations for Clinical Practice. Neuropsychiatr Dis Treat. Jan 8;16:55-70. doi: 10.2147/NDT.S229206.

Farinetti A, Aspesi D, Marraudino M, Marzola E, Amianto F, Abbate-Daga G, Gotti S. 2020a Sexually dimorphic behavioral effects of maternal separation in anorexic rats. Dev Psychobiol. Apr;62(3):297-309. doi: 10.1002/dev.21909.

Farinetti A, Aspesi D, Marraudino M, Marzola E, Abbate-Daga G, Gotti S. 2020 Maternal Separation in ABA Rats Promotes Cell Proliferation in the Dentate Gyrus of the Hippocampus. Neuroscience. Oct 15;446:238-248. doi: 10.1016/j.neuroscience. 2020.08.005.

Collantoni E, Tenconi E, Solmi M, Meneguzzo P, Marzola E, D'Agata F, Gotti S, Daga GA, Manara R, Favaro A. 2020 Hippocampal volumes in anorexia nervosa at different stages of the disorder. Eur Eat Disord Rev. Nov 13. doi: 10.1002/erv.2806.

Ruiz-Pino F, Miceli D, Franssen D, Vazquez MJ, Farinetti A, Castellano JM,Panzica G, Tena-Sempere M. Environmentally Relevant Perinatal Exposures toBisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice. Environ Health Perspect. 2019 Oct;127(10):107011. doi:10.1289/EHP5570. Epub 2019 Oct 25. PubMed PMID: 31652106.

Ponti G, Farinetti A, Marraudino M, Panzica G, Gotti S. Postnatal genisteinadministration selectively abolishes sexual dimorphism in specific hypothalamicdopaminergic system in mice. Brain Res. 2019 Dec 1;1724:146434. doi:10.1016/j.brainres.2019.146434. Epub 2019 Sep 3. PubMed PMID: 31491419.

Marraudino M, Farinetti A, Arevalo MA, Gotti S, Panzica G, Garcia-Segura LM. Sexually Dimorphic Effect of Genistein on Hypothalamic Neuronal Differentiationin Vitro. Int J Mol Sci. 2019 May 18;20(10). pii: E2465. doi:10.3390/ijms20102465. PubMed PMID: 31109056; PubMed Central PMCID: PMC6567056.

Nuzzi R, Scalabrin S, Becco A, Panzica G. Sex Hormones and Optic NerveDisorders: A Review. Front Neurosci. 2019 Feb 11;13:57. doi:10.3389/fnins.2019.00057. eCollection 2019. Review. PubMed PMID: 30804741; PubMedCentral PMCID: PMC6378504. 

Lagunas N, Marraudino M, de Amorim M, Pinos H, Collado P, Panzica G,Garcia-Segura LM, Grassi D. Estrogen receptor beta and G protein-coupled estrogenreceptor 1 are involved in the acute estrogenic regulation ofarginine-vasopressin immunoreactive levels in the supraoptic and paraventricular hypothalamic nuclei of female rats. Brain Res. 2019 Jun 1;1712:93-100. doi:10.1016/j.brainres.2019.02.002. Epub 2019 Feb 4. PubMed PMID: 30731078.

Marraudino M, Bonaldo B, Farinetti A, Panzica G, Ponti G, Gotti S. Metabolism Disrupting Chemicals and Alteration of Neuroendocrine Circuits Controlling FoodIntake and Energy Metabolism. Front Endocrinol (Lausanne). 2019 Jan 9;9:766. doi:10.3389/fendo.2018.00766. eCollection 2018. Review. PubMed PMID: 30687229; PubMedCentral PMCID: PMC6333703.

Montarolo F, Perga S, Martire S, Brescia F, Caldano M, Lo Re M, Panzica G,Bertolotto A. Study of the NR4A family gene expression in patients with multiple sclerosis treated with Fingolimod. Eur J Neurol. 2019 Apr;26(4):667-672. doi:10.1111/ene.13875. Epub 2018 Dec 22. PubMed PMID: 30565812.

Farinetti A, Aspesi D, Marraudino M, Marzola E, Amianto F, Abbate-Daga G, Gotti S. Sexually dimorphic behavioral effects of maternal separation in anorexic rats. Dev Psychobiol. 2019 Sep 9. doi: 10.1002/dev.21909. [Epub ahead of print] PubMed PMID: 31502241.

Last update: 11/04/2023 10:22
Location: https://neuroen.campusnet.unito.it/robots.html
Non cliccare qui!