Staff

1. Lanotte Michele Maria R. (Coordinator)
2. Zeme Sergio (Member)
3. Rizzi Laura (Member)
4. Fronda Chiara (Member)

Contacts

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Activity

The Functional Neurosurgery Center deals with the study and surgical treatment of Movement Disorders (Parkinson's disease, dystonic syndromes, tremor of different origins), spasticity, drug-resistant epilepsy, neurovascular conflict (trigeminal neuralgia, facial hemispasm).

The Functional Neurosurgery Center is "Regional Reference Center for the Surgical Treatment of Parkinson's Disease and Movement Disorders" (DGR No. 38-13744 of 25/10/2004).

The sector of excellence is represented by the neuromodulation techniques for drug-resistant epilepsy treatment (VNS), and Movement Disorders treatment, in particular Parkinson's disease (deep brain stimulation - DBS).

The neurosurgical procedures of deep brain stimulation are aimed to positioning small electrodes with stereotactic technique in specific brain areas. These electrodes, fed by a pulse generator (pacemaker) positioned at the thoracic level, are able to restore normal electrical activity of basal ganglia circuits. This activity is carried out in cooperation with the Neurological Clinic 2 directed by prof. L. Lopiano.

The research activity in the field of deep brain stimulation concerns patient selection criteria, surgical technique, the study and standardization of stimulation parameters, the clinical and neuropsychological follow-up, the mechanism of action of DBS.

In collaboration with prof. F. Benedetti and prof. L. Lopiano we also study the neurobiological correlates of the placebo effect in the human motor system in Parkinson's disease.

Group’s ECR Sectors:

LS5_1 - Neuroanatomy and Neurophysiology

LS5_11 - Neurological disorders (e.g. Alzheimer’s disease, Huntington’s disease, Parkinson’s disease)

LS7_7 Surgery

Publications

Albert U, Maina G, Aguglia A, Vitalucci A, Bogetto F, Fronda C, Ducati A, Lanotte M. (2015) Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study. BMC psychiatry 15 64 [DOI  PMID]

Agostini V, Lanotte M, Carlone M, Campagnoli M, Azzolin I, Scarafia R, Massazza G, Knaflitz M. (2015) Instrumented Gait Analysis for an Objective Pre-/Postassessment of Tap Test in Normal Pressure Hydrocephalus. Archives of physical medicine and rehabilitation [DOI  PMID]

Garbossa D, Altieri R, Specchia FM, Agnoletti A, Pilloni G, Lanotte M, Spaziante R, Ducati A. (2014) Are acute subdural hematomas possible without head trauma? Asian journal of neurosurgery 9(4) 218-22 [DOI  PMID]

Chirio D, Gallarate M, Peira E, Battaglia L, Muntoni E, Riganti C, Biasibetti E, Capucchio MT, Valazza A, Panciani P, Lanotte M, Annovazzi L, Caldera V, Mellai M, Filice G, Corona S, Schiffer D. (2014) Positive-charged solid lipid nanoparticles as paclitaxel drug delivery system in glioblastoma treatment. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 88(3) 746-58 [DOI  PMID]

Castelli L, Tonello D, Rizzi L, Zibetti M, Lanotte M, Lopiano L. (2014) Alexithymia in patients with Parkinson's disease treated with DBS of the subthalamic nucleus: a case-control study. Frontiers in psychology 5 1168 [DOI  PMID]

Zibetti M, Romagnolo A, Crobeddu E, Fornaro R, Merola A, Rizzone MG, Lopiano L, Lanotte M. (2014) Does intraoperative microrecording really increase the risk of hemorrhagic complications in deep brain stimulation? Brain stimulation 7(6) 911-2 [DOI  PMID]

Ricciardi L, Morgante L, Epifanio A, Zibetti M, Lanotte M, Lopiano L, Morgante F. (2014) Stimulation of the subthalamic area modulating movement and behavior.Parkinsonism & related disorders 20(11) 1298-300 [DOI  PMID]

Altieri R, Agnoletti A, Quattrucci F, Garbossa D, Calamo Specchia FM, Bozzaro M, Fornaro R, Mencarani C, Lanotte M, Spaziante R, Ducati A. (2014) Molecular biology of gliomas: present and future challenges. Translational medicine @ UniSa 10 29-37 [PMID]

Merola A, Rizzi L, Artusi CA, Zibetti M, Rizzone MG, Romagnolo A, Bernardini A, Lanotte M, Lopiano L. (2014) Subthalamic deep brain stimulation: clinical and neuropsychological outcomes in mild cognitive impaired parkinsonian patients. Journal of neurology 261(9) 1745-51 [DOI  PMID]

Battaglia L, Gallarate M, Peira E, Chirio D, Muntoni E, Biasibetti E, Capucchio MT, Valazza A, Panciani PP, Lanotte M, Schiffer D, Annovazzi L, Caldera V, Mellai M, Riganti C. (2014) Solid lipid nanoparticles for potential doxorubicin delivery in glioblastoma treatment: preliminary in vitro studies. Journal of pharmaceutical sciences 103(7) 2157-65 [DOI  PMID]

Frisaldi E, Carlino E, Lanotte M, Lopiano L, Benedetti F. (2014) Characterization of the thalamic-subthalamic circuit involved in the placebo response through single-neuron recording in Parkinson patients. Cortex; a journal devoted to the study of the nervous system and behavior 60 3-9 [DOI  PMID]

Merola A, Rizzi L, Zibetti M, Artusi CA, Montanaro E, Angrisano S, Lanotte M, Rizzone MG, Lopiano L. (2014) Medical therapy and subthalamic deep brain stimulation in advanced Parkinson's disease: a different long-term outcome? Journal of neurology, neurosurgery, and psychiatry 85(5) 552-9 [DOI  PMID]

Boeris D, Evins AI, Lanotte MM, Zeme S, Ducati A. (2014) Pontine compression caused by "surgiceloma" after trigeminal decompression: case report and literature review. Acta neurologica Belgica 114(3) 229-31 [DOI  PMID]

Merola A, Zibetti M, Artusi CA, Rizzi L, Angrisano S, Lanotte M, Lopiano L, Rizzone MG. (2013) 80 Hz versus 130 Hz subthalamic nucleus deep brain stimulation: effects on involuntary movements. Parkinsonism & related disorders 19(4) 453-6 [DOI  PMID]

Torta DM, Vizzari V, Castelli L, Zibetti M, Lanotte M, Lopiano L, Geminiani G. (2012) Impulsivities and Parkinson's disease: delay aversion is not worsened by Deep Brain Stimulation of the subthalamic nucleus. PloS one 7(9) e43261 [DOI  PMID]

Panciani PP, Fontanella M, Tamagno I, Battaglia L, Garbossa D, Inghirami G, Fagioli F, Pagano M, Ducati A, Lanotte M. (2012) Stem cells based therapy in high grade glioma: why the intraventricular route should be preferred? Journal of neurosurgical sciences 56(3) 221-9 [PMID]

Lanotte M, Panciani PP, Magistrello M, Naldi A, Fontanella M, Ducati A, Giordana MT. (2013) Central neuropathic itch as the presenting symptom of an intramedullary cavernous hemangioma: case report and review of literature. Clinical neurology and neurosurgery 115(4) 454-6 [DOI  PMID]

Panciani PP, Fontanella M, Garbossa D, Agnoletti A, Ducati A, Lanotte M. (2012) 5-aminolevulinic acid and neuronavigation in high-grade glioma surgery: results of a combined approach. Neurocirugia (Asturias, Spain) 23(1) 23-8 [DOI  PMID]

Merola A, Zibetti M, Artusi CA, Marchisio A, Ricchi V, Rizzi L, Angrisano S, Arduino N, Lanotte M, Rizzone M, Lopiano L. (2012) Subthalamic nucleus deep brain stimulation outcome in young onset Parkinson's disease: a role for age at disease onset? Journal of neurology, neurosurgery, and psychiatry 83(3) 251-7 [DOI  PMID]

Zibetti M, Merola A, Rizzi L, Ricchi V, Angrisano S, Azzaro C, Artusi CA, Arduino N, Marchisio A, Lanotte M, Rizzone M, Lopiano L. (2011) Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 26(13) 2327-34 [DOI  PMID]

Panciani PP, Fontanella M, Schatlo B, Garbossa D, Agnoletti A, Ducati A, Lanotte M. (2012) Fluorescence and image guided resection in high grade glioma. Clinical neurology and neurosurgery 114(1) 37-41 [DOI  PMID]

Caldera V, Mellai M, Annovazzi L, Piazzi A, Lanotte M, Cassoni P, Schiffer D. (2011) Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres. Journal of oncology 2011 314962 [DOI  PMID]

Ricchi V, Zibetti M, Angrisano S, Merola A, Arduino N, Artusi CA, Rizzone M, Lopiano L, Lanotte M. (2012) Transient effects of 80 Hz stimulation on gait in STN DBS treated PD patients: a 15 months follow-up study. Brain stimulation 5(3) 388-92 [DOI  PMID]

Merola A, Zibetti M, Angrisano S, Rizzi L, Ricchi V, Artusi CA, Lanotte M, Rizzone MG, Lopiano L. (2011) Parkinson's disease progression at 30 years: a study of subthalamic deep brain-stimulated patients. Brain : a journal of neurology 134(Pt 7) 2074-84 [DOI  PMID]

Merola A, Zibetti M, Angrisano S, Rizzi L, Lanotte M, Lopiano L. (2011) Comparison of subthalamic nucleus deep brain stimulation and Duodopa in the treatment of advanced Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 26(4) 664-70 [DOI  PMID]

Lanotte M, Cavallo M, Franzini A, Grifi M, Marchese E, Pantaleoni M, Piacentino M, Servello D. (2010) A computational model to compare different investment scenarios for mini-stereotactic frame approach to deep brain stimulation surgery. Journal of neurosurgical sciences 54(3) 91-7 [PMID]

Albera R, Canale A, Parandero F, Ducati A, Lanotte M. (2011) Surgical indication in Meniere's disease therapy: clinical and epidemiological aspects. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 268(7) 967-72 [DOI  PMID]

Zibetti M, Rizzi L, Colloca L, Cinquepalmi A, Angrisano S, Castelli L, Lanotte M, Lopiano L. (2010) Probable REM sleep behaviour disorder and STN-DBS outcome in Parkinson's Disease. Parkinsonism & related disorders 16(4) 265-9 [DOI  PMID]

Zibetti M, Rosso M, Cinquepalmi A, Lanotte M, Angrisano S, Rabbia C, Valpreda S, Lopiano L. (2010) Asymptomatic deep venous thrombosis after deep brain stimulation for Parkinson disease. Stereotactic and functional neurosurgery 88(2) 94-7 [DOI  PMID]

Zibetti M, Cinquepalmi A, Angrisano S, Lanotte M, Lopiano L. (2009) Management of antiparkinsonian therapy during chronic subthalamic stimulation in Parkinson's disease. Parkinsonism & related disorders 15 Suppl 4 S76-80 [DOI  PMID]