Ageing and Alzheimer's disease

Principal Investigator: Prof.ssa Elena Tamagno

Group members:

• Elena Tamagno (Full Professor, Principal Investigator)
• Michela Guglielmotto (Associate Professor, Principal Investigator)
• Valeria Vasciaveo (PhD Student)

Address and contacts:

• Michela Guglielmotto, 0116706604, michela.guglielmotto@unito.it
• Elena Tamagno, 0116706604, elena.tamagno@unito.it
• Valeria Vasciaveo, 0116706632, valeria.vasciaveo@unito.it
• Giulia Morello, 0116706632, g.morello@unito.it

External website link

• https://www.nico.ottolenghi.unito.it/Ricerca/Gruppi-di-ricerca/Invecchiamento-e-malattia-di-Alzheimer

Main research activities of the research group

Our group studies the age-related cellular and molecular mechanisms that cause Alzheimer's disease, in order to contribute to the development of new therapies. The primary neuropathological events in Alzheimer's disease, such as  in all other forms of dementia, involve the abnormal formation of pathological protein species. Advances in the biomolecular field provide the tools needed to unravel the mechanisms of synthesis, trafficking and accumulation of these proteins in the brain. Research in this area has begun to produce promising clues about the role of these proteins in neural function, dysfunction and cell death and to suggest strategies to correct this molecular damage.

List of 10 main publications

• Vasciaveo V, Iadarola A, Casile A, Dante D, Morello G, Minotta L, Tamagno E, Cicolin A, Guglielmotto M. Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models. Acta Neuropathol Commun. 2023 Jan 18;11(1):16. doi: 10.1186/s40478-022-01498-2. PMID: 36653878; PMCID: PMC9850555.
• Guglielmotto M, Manassero G, Vasciaveo V, Venezia M, Tabaton M, Tamagno E. Estrogens Inhibit Amyloid-β-Mediated Paired Helical Filament-Like Conformation of Tau Through Antioxidant Activity and miRNA 218 Regulation in hTau Mice. J Alzheimers Dis. 2020;77(3):1339-1351. doi: 10.3233/JAD-200707. PMID: 32804095.
• Guglielmotto M, Repetto IE, Monteleone D, Vasciaveo V, Franchino C, Rinaldi S, Tabaton M, Tamagno E. Stroke and Amyloid-β Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response. J Alzheimers Dis. 2019;71(3):907-920. doi: 10.3233/JAD-190494. PMID: 31450501.
• Guglielmotto M, Monteleone D, Vasciaveo V, Repetto IE, Manassero G, Tabaton M, Tamagno E. The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer's and Vascular Disease. Front Aging Neurosci. 2017 Sep 29;9:320. doi: 10.3389/fnagi.2017.00320. PMID: 29033830; PMCID: PMC5627155.
• Guglielmotto M, Monteleone D, Piras A, Valsecchi V, Tropiano M, Ariano S, Fornaro M, Vercelli A, Puyal J, Arancio O, Tabaton M, Tamagno E. Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis. Autophagy. 2014 Oct 1;10(10):1827-43. doi: 10.4161/auto.30001. Epub 2014 Aug 12. PMID: 25136804; PMCID: PMC4198366.
• Guglielmotto M, Monteleone D, Giliberto L, Fornaro M, Borghi R, Tamagno E, Tabaton M. Amyloid-β₄₂ activates the expression of BACE1 through the JNK pathway. J Alzheimers Dis. 2011;27(4):871-83. doi: 10.3233/JAD-2011-110884. PMID: 21897006.
• Guglielmotto M, Aragno M, Autelli R, Giliberto L, Novo E, Colombatto S, Danni O, Parola M, Smith MA, Perry G, Tamagno E, Tabaton M. The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha. J Neurochem. 2009 Feb;108(4):1045-56. doi: 10.1111/j.1471-4159.2008.05858.x. PMID: 19196431.
• Tamagno E, Guglielmotto M, Aragno M, Borghi R, Autelli R, Giliberto L, Muraca G, Danni O, Zhu X, Smith MA, Perry G, Jo DG, Mattson MP, Tabaton M. Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem. 2008 Feb;104(3):683-95. doi: 10.1111/j.1471-4159.2007.05072.x. Epub 2007 Nov 14. PMID: 18005001; PMCID: PMC2220052.
• Tamagno E, Bardini P, Guglielmotto M, Danni O, Tabaton M. The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression. Free Radic Biol Med. 2006 Jul 15;41(2):202-12. doi: 10.1016/j.freeradbiomed.2006.01.021. Epub 2006 Feb 14. PMID: 16814100.
• Tamagno E, Guglielmotto M, Bardini P, Santoro G, Davit A, Di Simone D, Danni O, Tabaton M. Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress. Neurobiol Dis. 2003 Nov;14(2):291-301. doi: 10.1016/s0969-9961(03)00131-1. PMID: 14572450.