Neuroendocrinology

Principal Investigator: Stefano Gotti

Group members:

• Stefano Gotti (Principal Investigator)
• Brigitta Bonaldo (Post-Doc)
• Chiara Ballan (PhD Student)

Address and contacts:

• Stefano Gotti 0116706610, stefano.gotti@unito.it

External website link

• https://nico.ottolenghi.unito.it/Ricerca/Gruppi-di-ricerca/Neuroendocrinologia

Main research activities of the research group
The central focus of our researches is the study of the interactions among steroids and nervous circuits. Our previous studies have clarified the role of early exposure to gonadal hormones in the differentiation of sexually dimorphic circuits and behaviors in birds and mammals.

List of 10 main publications

• Bonaldo B, Gioiosa L,  Panzica GC, Marraudino M 2022  Exposure to either bisphenol A or S represents a risk for crucial behaviors for pup survival, such as spontaneous maternal behavior in mice .    https://doi.org/10.1159/000526074.
• Aspesi D, Farinetti A, Marraudino M, Morgan GSK, Marzola E, Abbate-Daga G, Gotti S 2021 Maternal separation alters the reward system of activity-based anorexia rats. Nov;133:105393. doi: 10.1016/j.psyneuen.2021.105393.
• Marraudino M, Ponti G, Moussu C, Farinetti A, Macchi E, Accornero P, Gotti S, Collado P, Keller M, Panzica GC 2021 Early Postnatal Genistein Administration Affects Mice Metabolism and Reproductionin a Sexually Dimorphic Way.   Metabolites 11, 449. DOI: 10.3390/metabo11070449.
• Marraudino M, Bo E, Carlini E, Farinetti A, Ponti G, Zanella I, Di Lorenzo D, Panzica GC, Gotti S. Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors 2021 Metabolites Jun 9;11(6):368. doi: 10.3390/metabo11060368. PMID: 34207679; PMCID: PMC8228876.
• Farinetti A, Aspesi D, Marraudino M, Marzola E, Amianto F, Abbate-Daga G, Gotti S. 2020 Sexually dimorphic behavioral effects of maternal separation in anorexic rats. Dev Psychobiol. Apr;62(3):297-309. doi: 10.1002/dev.21909.
• Farinetti A, Aspesi D, Marraudino M, Marzola E, Abbate-Daga G, Gotti S. 2020 Maternal Separation in ABA Rats Promotes Cell Proliferation in the Dentate Gyrus of the Hippocampus.  Oct 15;446:238-248. doi: 10.1016/j.neuroscience. 2020.08.005.
• Ponti G, Farinetti A, Marraudino M, Panzica G, Gotti S. 2019 Postnatal genisteinadministration selectively abolishes sexual dimorphism in specific hypothalamic dopaminergic system in mice. Brain Res. Dec 1;1724:146434. doi:10.1016/j.brainres.2019.146434. Epub 2019 Sep 3. PubMed PMID: 31491419.
• Marraudino M, Farinetti A, Arevalo MA, Gotti S, Panzica G, Garcia-Segura LM. 2019 Sexually Dimorphic Effect of Genistein on Hypothalamic Neuronal Differentiationin Vitro. Int J Mol Sci. May 18;20(10). pii: E2465. doi:10.3390/ijms20102465. PubMed PMID: 31109056; PubMed Central PMCID: PMC6567056.
• Farinetti A, Aspesi D, Marraudino M, Marzola E, Amianto F, Abbate-Daga G, Gotti S. 2019 Sexually dimorphic behavioral effects of maternal separation in anorexic rats. Dev Psychobiol. Sep 9. doi: 10.1002/dev.21909. [Epub ahead of print] PubMed PMID: 31502241.
• Farinetti A, Marraudino M, Ponti G, Panzica GC, Gotti S 2018 Chronic treatment with tributyltin induces sexually dimorphic alterations in the hypothalamic POMC system of adult mice. Cell Tissue Research 2018 Aug 4. doi: 10.1007/s00441-018-2896-9.