Functional Neurosurgery

Principal Investigator: Prof. Michele Lanotte

Group members:

Michele Lanotte (Principal Investigator)
Laura Rizzi (Team member)
Sergio Zeme (Team member)
Pietro Zeppa (PhD Student)

Address and contacts:

Michele Lanotte 011-6709300 lanotte@unito.it

Main research activities of the research group
Functional Neurosurgery deals with the study and the surgical treatment of movement disorders (Parkinson's disease, dystonia, tremors of different etiology), spasticity, drug-resistant epilepsy, pain, trigeminal neuralgia.
The Unit of Functional Neurosurgery is a "Reference Center" in Piedmont region for the surgical treatment of Parkinson's disease and other movement disorders (D.G.R. n° 38-13744, 25/10/2004).
Excellence activity is represented by neuromodulation surgical techniques such as vagus nerve stimulation (VNS) for drug-resistant epilepsy and deep brain stimulation (DBS) for movement disorders.

List of 10 main publications

Albert U., Maina G., Aguglia A., Vitalucci A., Bogetto F., Fronda C., Ducati A., Lanotte M. VAGUS NERVE STIMULATION FOR TREATMENT-RESISTANT MOOD DISORDERS: A LONG-TERM NATURALISTIC STUDY. 2015; BMC Psychiatry 15:64.
Benedetti F., Frisaldi E., Carlino E., Giudetti L., Pampallona A., Zibetti M., Lanotte M., Lopiano L. TEACHING NEURONS TO RESPOND TO PLACEBOS. J. Physiol. 2016; 594(19):5647-5660.
Reich M.M., Brumberg J., Pozzi N.G., Marotta G., Roothans J., Astrom M., Musacchio T., Lopiano L., Lanotte M., Lehrke R., Buck A.K., Volkmann J., Isaias I.U. PROGRESSIVE GAIT ATAXIA FOLLOWING DEEP BRAIN STIMULATION FOR ESSENTIAL TREMOR: ADVERSE EFFECT OR LACK OF EFFICACY? Brain 2016; 139:2948-2956.
Battaglia L., Muntoni E., Chirio D., Peira E., Annovazzi L., Schiffer D., Mellai M., Riganti C., Salaroglio I.C., Lanotte M., Panciani P., Capucchio M.T., Valazza A., Biasibetti E., Gallarate M. SOLID LIPID NANOPARTICLES BY COACERVATION LOADED WITH A METHOTREXATE PRODRUG: PRELIMINARY STUDY FOR GLIOMA TREATMENT. Nanomedicine (Lond.) 2017; 12(6):639-656.
Enrici I., Mitkova A., Castelli L., Lanotte M., Lopiano L., Adenzato M. DEEP BRAIN STIMULATION OF THE SUBTHALAMIC NUCLEUS DOES NOT NEGATIVELY AFFECT SOCIAL COGNITIVE ABILITIES OF PATIENTS WITH PARKINSON’S DISEASE. Sci. Rep. 2017; 7(1):9413.
Tesio V., Rizzi L., Jiang T., Fronda C., Lanotte M., Castelli L. DEEP BRAIN STIMULATION OF THE SUBTHALAMIC NUCLEUS IN PARKINSON’S DISEASE: RELATIONSHIP BETWEEN THE ELECTRODE TRAJECTORY AND COGNITIVE DECLINE. Parkinsonism Relat. Disord. 2019; 61:45-49.
Ghislieri M., Agostini V., Rizzi L., Knaflitz M., Lanotte M. ATYPICAL GAIT CYCLES IN PARKINSON’S DISEASE. Sensors 2021; 21:5079. doi.org/10.3390/s21155079.
Arlotti M., Colombo M., Bonfanti A., Mandat T., Lanotte M.M., Pirola E., Borellini L., Rampini P., Eleopra R., Rinaldo S., Romito L., Janssen M.L.F., Priori A., Marceglia S.A NEW IMPLANTABLE CLOSED-LOOP CLINICAL NEURAL INTERFACE: FIRST APPLICATION IN PARKINSON’S DISEASE. Front. Neurosci. 2021; 15 art. 763235:1-12.
Petrone S., Cofano F., Nicolosi F., Spena G., Moschino M., Di Perna G., Lavorato A., Lanotte M.M., Garbossa D. VIRTUAL-AUGMENTED REALITY AND LIFE-LIKE NEUROSURGICAL SIMULATOR FOR TRAINING: FIRST EVALUATION OF A HANDS-ON EXPERIENCE FOR RESIDENTS. Front. Surg. 2022; 9 art. 862948:1-9.
Zeppa P., Fraccalvieri M., Fronda C., Lo Bue E., Rizzi L., Caliendo V., Lanotte M.M. HARDWARE-RELATED SKIN EROSION IN DEEP BRAIN STIMULATION FOR PARKINSON’S DISEASE: HOW FAR CAN WE GO? Brain Sci. 2022; 12:1715. doi.org/10.3390/brainsci12121715.