Neuro-Oncology

Principal Investigator: Prof. ssa Roberta Rudà

Group members:

Roberta Rudà (Principal Investigator, PA)
Francesco Bruno (PhD student)
Allegra Carpaneto (Team member)

Address and contacts:

Roberta Rudà, tel: 0116709169, email: roberta.ruda@unito.it

Main research activities of the research group
The Research Group is involved in primary and secondary brain tumors and neurological complications of extranervous tumors and their treatments. Thus far, there are severa l ongoing research projects. The first one includes phase 2 and 3 clinical trials (monoinstituional, multicentric national and international) on: new targeted agents for glioblastoma, grade 2 and 3 glioma, medulloblastoma, ependymoma, primary central nervous system lymphoma, neoplastic meningitis, and rare tumors. A second research field is clinico-translational projects on epilepsy, monitoring with neuroimaging/neuropsychology in grade 2 gliomas, liquid biopsy in primary central nervous system lymphoma, and molecular analysis of STAT3 expression on reactive astrocytes in brain metastases. The Research Group is actively involved in several internation network, such as EORTC, EURACAN, and RANO.

List of 10 main publications

Capper D, Reifenberger G, French PJ, Schweizer L, Weller M, Touat M, Niclou SP, Euskirchen P, Haberler C, Hegi ME, Brandner S, Le Rhun E, Rudà R, Sanson M, Tabatabai G, Sahm F, Wen PY, Wesseling P, Preusser M, van den Bent MJ. EANO guideline on rational molecular testing of gliomas, glioneuronal and neuronal tumors in adults for targeted therapy selection. Neuro Oncol. 2023 Jan 12:noad008. doi: 10.1093/neuonc/noad008. Epub ahead of print. PMID: 36632791.
Rudà R, Capper D, Waldman AD, Pallud J, Minniti G, Kaley TJ, Bouffet E, Tabatabai G, Aronica E, Jakola AS, Pfister SM, Schiff D, Lassman AB, Solomon DA, Soffietti R, Weller M, Preusser M, Idbaih A, Wen PY, van den Bent MJ. EANO - EURACAN - SNO Guidelines on circumscribed astrocytic gliomas, glioneuronal, and neuronal tumors. Neuro Oncol. 2022 Dec 1;24(12):2015-2034. doi: 10.1093/neuonc/noac188. PMID: 35908833; PMCID: PMC9713532.
Karschnia P, Young JS, Dono A, Häni L, Sciortino T, Bruno F, Juenger ST, Teske N, Morshed RA, Haddad AF, Zhang Y, Stoecklein S, Weller M, Vogelbaum MA, Beck J, Tandon N, Hervey-Jumper S, Molinaro AM, Rudà R, Bello L, Schnell O, Esquenazi Y, Ruge MI, Grau SJ, Berger MS, Chang SM, van den Bent M, Tonn JC. Prognostic validation of a new classification system for extent of resection in glioblastoma: a report of the RANO resect group. Neuro Oncol. 2022 Aug 12:noac193. doi: 10.1093/neuonc/noac193. Epub ahead of print. PMID: 35961053.
Soffietti R, Bettegowda C, Mellinghoff IK, Warren KE, Ahluwalia MS, De Groot JF, Galanis E, Gilbert MR, Jaeckle KA, Le Rhun E, Rudà R, Seoane J, Thon N, Umemura Y, Weller M, van den Bent MJ, Vogelbaum MA, Chang SM, Wen PY. Liquid biopsy in gliomas: A RANO review and proposals for clinical applications. Neuro Oncol. 2022 Jun 1;24(6):855-871. doi: 10.1093/neuonc/noac004. PMID: 34999836; PMCID: PMC9159432.
Rudà R, Bruno F, Ius T, Silvani A, Minniti G, Pace A, Lombardi G, Bertero L, Pizzolitto S, Pollo B, Conti Nibali M, Pellerino A, Migliore E, Skrap M, Bello L, Soffietti R. IDH wild-type grade 2 diffuse astrocytomas: prognostic factors and impact of treatments within molecular subgroups. Neuro Oncol. 2022 May 4;24(5):809-820. doi: 10.1093/neuonc/noab239. PMID: 34651653; PMCID: PMC9071340.
van den Bent MJ, Tesileanu CMS, Wick W, Sanson M, Brandes AA, Clement PM, Erridge S, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, Reijneveld J, Enting RH, Caparrotti F, Lesimple T, Clenton S, Gijtenbeek A, Lim E, Herrlinger U, Hau P, Dhermain F, de Heer I, Aldape K, Jenkins RB, Dubbink HJ, Kros JM, Wesseling P, Nuyens S, Golfinopoulos V, Gorlia T, French P, Baumert BG. Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study. Lancet Oncol. 2021 Jun;22(6):813-823. doi: 10.1016/S1470-2045(21)00090-5. Epub 2021 May 14. PMID: 34000245; PMCID: PMC8191233.
Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G, Bendszus M, Balana C, Chinot O, Dirven L, French P, Hegi ME, Jakola AS, Platten M, Roth P, Rudà R, Short S, Smits M, Taphoorn MJB, von Deimling A, Westphal M, Soffietti R, Reifenberger G, Wick W. EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nat Rev Clin Oncol. 2021 Mar;18(3):170-186. doi: 10.1038/s41571-020-00447-z. Epub 2020 Dec 8. Erratum in: Nat Rev Clin Oncol. 2022 May;19(5):357-358. PMID: 33293629; PMCID: PMC7904519.
Rudà R, Houillier C, Maschio M, Reijneveld JC, Hellot S, De Backer M, Chan J, Joeres L, Leunikava I, Glas M, Grant R. Effectiveness and tolerability of lacosamide as add-on therapy in patients with brain tumor-related epilepsy: Results from a prospective, noninterventional study in European clinical practice (VIBES). Epilepsia. 2020 Apr;61(4):647-656. doi: 10.1111/epi.16486. PMID: 32329527; PMCID: PMC7384112.
Rudà R, Mo F, Pellerino A. Epilepsy in brain metastasis: an emerging entity. Curr Treat Options Neurol. 2020 Feb 8;22(2):6. doi: 10.1007/s11940-020-0613-y. PMID: 32034533.
Rudà R, Pellerino A, Pace A, Carapella CM, Dealis C, Caroli M, Faedi M, Bello L, Migliore E, Marchese G, Bertero L, Cassoni P, Soffietti R. Efficacy of initial temozolomide for high-risk low grade gliomas in a phase II AINO (Italian Association for Neuro-Oncology) study: a post-hoc analysis within molecular subgroups of WHO 2016. J Neurooncol. 2019 Oct;145(1):115-123. doi: 10.1007/s11060-019-03277-x. Epub 2019 Sep 25. Erratum in: J Neurooncol. 2019 Dec;145(3):593. PMID: 31556015