PICTURE
NOT AVAILABLE

for the Study of Movement Disorders

Neurology

Staff

Lopiano Leonardo (Coordinator)
Rizzone Mario Giorgio (Member)
(Member)
Artusi Carlo Alberto (Member)
(Member)
Di Gleria Luisella (Member)
Palermo Sara (Member)
Romagnolo Alberto (Member)

Contacts

Activity

The Centre deals with the study of movement disorders (Parkinson's disease, dystonic syndromes, tremors) and peripheral nervous system (PNS) diseases. Research activities range from the etiology, genetics, proteomics up to innovative therapies.

In particular we are interested in the monogenic forms of Parkinson's disease (PD) and in the possibility to identify genetic markers for early diagnosis and for a more precise characterization of Parkinsonian syndromes related to disease progression (very useful in sporadic form that accounts for the major part of cases). The Center collaborates with the Dep. of Clinical Genetics at the University of Rotterdam (Prof. Bonifati) and with the Lab. of Molecular Genetics - Presidio OIRM St. Anna - to identify monogenic forms of PD. For several years we cooperate with Prof. Fasano (Lab. of Biochemistry and Proteomics at the University of Insubria) with the aim to identifying molecular markers for early diagnosis of PD. A prominent sector in the Center activities is the deep brain stimulation, a neurosurgical operation in which stimulating electrodes are applied in specific intracerebral targets and are able to normalize the electrical activity of the basal ganglia circuits. The main indication is represented by PD at an advanced stage, essential tremor and dystonic syndromes. The Centre, in collaboration with the Unit of Functional Neurosurgery and Stereotactic of the Neuroscience Department, headed by Prof. Lanotte, is a regional and national reference center for patient selection, intra-operative monitoring, and follow-up of operated patients. In addition, in collaboration with Prof. Benedetti (Section of Human Physiology, Dep. Of Neurosciences) we performed studies on neurophysiological mechanisms of the placebo effect in the motor system.

The Centre is also involved in the clinical and neurophysiological aspects of the treatment of adult focal dystonias, directing patients to the various available treatments .

As for the PNS the main sectors of interest are represented by the Clinical Neurophysiology, neuropathies, neuromuscular junction diseases, and rare diseases. The Centre deals with the main methods for the PNS study (electromyography, electroneurography, repetitive stimulation, study of single fiber, motor and somatosensory evoked potentials) and has gained extensive experience and excellence in the diagnosis and treatment of chronic dysimmune neuropathies, for which in 2013 it was recognized Reference Centre of the European Orphanet Network.

Finally, another area of interest is represented by epileptic complex syndromes. The main activities are represented by the Video-EEG recording of seizures and by the pre-surgical study of drug-resistant patients.

Group’s ECR Sectors:

LS5_11 - Neurological disorders (e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease)

LS5_2 - Molecular and cellular neuroscience

LS5_7 - Cognition (e.g. learning, memory, emotions, speech)

Publications

Enrici I, Adenzato M, Ardito RB, Mitkova A, Cavallo M, Zibetti M, Lopiano L, Castelli L. (2015) Emotion Processing in Parkinson's Disease: A Three-Level Study on Recognition, Representation, and Regulation. PloS one 10(6) e0131470 [DOI PMID]

Cocito D, Merola A, Romagnolo A, Peci E, Toscano A, Mazzeo A, Gentile L, Russo M, Fazio R, Filosto M, Siciliano G, Schirinzi E, Nobile-Orazio E, Lopiano L. (2015) Subcutaneous immunoglobulin in CIDP and MMN: a different long-term clinical response? Journal of neurology, neurosurgery, and psychiatry [DOI PMID]

Merola A, Romagnolo A, Bernardini A, Rizzi L, Artusi CA, Lanotte M, Rizzone MG, Zibetti M, Lopiano L. (2015) Earlier versus later subthalamic deep brain stimulation in Parkinson's disease. Parkinsonism & related disorders 21(8) 972-5 [DOI PMID]

Barone P, Santangelo G, Morgante L, Onofrj M, Meco G, Abbruzzese G, Bonuccelli U, Cossu G, Pezzoli G, Stanzione P, Lopiano L, Antonini A, Tinazzi M. (2015) A randomized clinical trial to evaluate the effects of rasagiline on depressive symptoms in non-demented Parkinson's disease patients. European journal of neurology : the official journal of the European Federation of Neurological Societies 22(8) 1184-91 [DOI PMID]

Cocito D, Romagnolo A, Rosso M, Peci E, Lopiano L, Merola A. (2015) CIDP-like neuropathies in graft versus host disease. Journal of the peripheral nervous system : JPNS 20(1) 1-6 [DOI PMID]

Chio A, Calvo A, Moglia C, Canosa A, Brunetti M, Barberis M, Restagno G, Conte A, Bisogni G, Marangi G, Moncada A, Lattante S, Zollino M, Sabatelli M, Bagarotti A, Corrado L, Mora G, Bersano E, Mazzini L, D'Alfonso S. (2015) ATXN2 polyQ intermediate repeats are a modifier of ALS survival. Neurology 84(3) 251-8 [DOI PMID]

Castelli L, Tonello D, Rizzi L, Zibetti M, Lanotte M, Lopiano L. (2014) Alexithymia in patients with Parkinson's disease treated with DBS of the subthalamic nucleus: a case-control study. Frontiers in psychology 5 1168 [DOI PMID]

Zibetti M, Romagnolo A, Crobeddu E, Fornaro R, Merola A, Rizzone MG, Lopiano L, Lanotte M. (2014) Does intraoperative microrecording really increase the risk of hemorrhagic complications in deep brain stimulation? Brain stimulation 7(6) 911-2 [DOI PMID]

Ricciardi L, Morgante L, Epifanio A, Zibetti M, Lanotte M, Lopiano L, Morgante F. (2014) Stimulation of the subthalamic area modulating movement and behavior. Parkinsonism & related disorders 20(11) 1298-300 [DOI PMID]

Cocito D, Merola A, Peci E, Mazzeo A, Fazio R, Francia A, Valentino P, Liguori R, Filosto M, Siciliano G, Clerici AM, Lelli S, Marfia GA, Antonini G, Cecconi I, Nobile-Orazio E, Lopiano L. (2014) Subcutaneous immunoglobulin in CIDP and MMN: a short-term nationwide study. Journal of neurology 261(11) 2159-64 [DOI PMID]

Amanzio M, Palermo S, Zibetti M, Leotta D, Rosato R, Geminiani G, Lopiano L. (2014) Self-unawareness of levodopa induced dyskinesias in patients with Parkinson's disease. Brain and cognition 90 135-41 [DOI PMID]

Chio A, Calvo A, Bovio G, Canosa A, Bertuzzo D, Galmozzi F, Cugnasco P, Clerico M, De Mercanti S, Bersano E, Cammarosano S, Ilardi A, Manera U, Moglia C, Sideri R, Marinou K, Bottacchi E, Pisano F, Cantello R, Mazzini L, Mora G. (2014) Amyotrophic lateral sclerosis outcome measures and the role of albumin and creatinine: a population-based study. JAMA neurology 71(9) 1134-42 [DOI PMID]

Fantini ML, Macedo L, Zibetti M, Sarchioto M, Vidal T, Pereira B, Marques A, Debilly B, Derost P, Ulla M, Vitello N, Cicolin A, Lopiano L, Durif F. (2015) Increased risk of impulse control symptoms in Parkinson's disease with REM sleep behaviour disorder. Journal of neurology, neurosurgery, and psychiatry 86(2) 174-9 [DOI PMID]

Cocito D, Peci E, Ciaramitaro P, Merola A, Lopiano L. (2014) Short-term efficacy of ultramicronized palmitoylethanolamide in peripheral neuropathic pain. Pain research and treatment 2014 854560 [DOI PMID]

Merola A, Rizzi L, Artusi CA, Zibetti M, Rizzone MG, Romagnolo A, Bernardini A, Lanotte M, Lopiano L. (2014) Subthalamic deep brain stimulation: clinical and neuropsychological outcomes in mild cognitive impaired parkinsonian patients. Journal of neurology 261(9) 1745-51 [DOI PMID]

Alberio T, McMahon K, Cuccurullo M, Gethings LA, Lawless C, Zibetti M, Lopiano L, Vissers JP, Fasano M. (2014) Verification of a Parkinson's disease protein signature in T-lymphocytes by multiple reaction monitoring. Journal of proteome research 13(8) 3554-61 [DOI PMID]

Montuschi A, Iazzolino B, Calvo A, Moglia C, Lopiano L, Restagno G, Brunetti M, Ossola I, Lo Presti A, Cammarosano S, Canosa A, Chio A. (2015) Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy. Journal of neurology, neurosurgery, and psychiatry 86(2) 168-73 [DOI PMID]

Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J. (2014) PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology. Brain : a journal of neurology 137(Pt 5) 1361-73 [DOI PMID]

Rizzone MG, Fasano A, Daniele A, Zibetti M, Merola A, Rizzi L, Piano C, Piccininni C, Romito LM, Lopiano L, Albanese A. (2014) Long-term outcome of subthalamic nucleus DBS in Parkinson's disease: from the advanced phase towards the late stage of the disease? Parkinsonism & related disorders 20(4) 376-81 [DOI PMID]

Lazzaro C, Lopiano L, Cocito D. (2014) Subcutaneous vs intravenous administration of immunoglobulin in chronic inflammatory demyelinating polyneuropathy: an Italian cost-minimization analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 35(7) 1023-34 [DOI PMID]

Frisaldi E, Carlino E, Lanotte M, Lopiano L, Benedetti F. (2014) Characterization of the thalamic-subthalamic circuit involved in the placebo response through single-neuron recording in Parkinson patients. Cortex; a journal devoted to the study of the nervous system and behavior 60 3-9 [DOI PMID]

Cistaro A, Pagani M, Montuschi A, Calvo A, Moglia C, Canosa A, Restagno G, Brunetti M, Traynor BJ, Nobili F, Carrara G, Fania P, Lopiano L, Valentini MC, Chio A. (2014) The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients. European journal of nuclear medicine and molecular imaging 41(5) 844-52 [DOI PMID]

Zibetti M, Merola A, Artusi CA, Rizzi L, Angrisano S, Reggio D, De Angelis C, Rizzone M, Lopiano L. (2014) Levodopa/carbidopa intestinal gel infusion in advanced Parkinson's disease: a 7-year experience. European journal of neurology : the official journal of the European Federation of Neurological Societies 21(2) 312-8 [DOI PMID]

Stocchi F, Antonini A, Barone P, Tinazzi M, Zappia M, Onofrj M, Ruggieri S, Morgante L, Bonuccelli U, Lopiano L, Pramstaller P, Albanese A, Attar M, Posocco V, Colombo D, Abbruzzese G. (2014) Early DEtection of wEaring off in Parkinson disease: the DEEP study. Parkinsonism & related disorders 20(2) 204-11 [DOI PMID]

Santangelo G, Barone P, Abbruzzese G, Ferini-Strambi L, Antonini A. (2014) Validation of the Italian version of Parkinson's disease-cognitive rating scale (PD-CRS). Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 35(4) 537-44 [DOI PMID]

Merola A, Rizzi L, Zibetti M, Artusi CA, Montanaro E, Angrisano S, Lanotte M, Rizzone MG, Lopiano L. (2014) Medical therapy and subthalamic deep brain stimulation in advanced Parkinson's disease: a different long-term outcome? Journal of neurology, neurosurgery, and psychiatry 85(5) 552-9 [DOI PMID]

Ceravolo R, Cossu G, Bandettini di Poggio M, Santoro L, Barone P, Zibetti M, Frosini D, Nicoletti V, Manganelli F, Iodice R, Picillo M, Merola A, Lopiano L, Paribello A, Manca D, Melis M, Marchese R, Borelli P, Mereu A, Contu P, Abbruzzese G, Bonuccelli U. (2013) Neuropathy and levodopa in Parkinson's disease: evidence from a multicenter study. Movement disorders : official journal of the Movement Disorder Society 28(10) 1391-7 [DOI PMID]

Merola A, Zibetti M, Rizzone MG, Troiano M, Artusi CA, Angrisano S, Cocito D, Lopiano L. (2014) Prospective assessment of peripheral neuropathy in Duodopa-treated parkinsonian patients. Acta neurologica Scandinavica 129(1) e1-5 [DOI PMID]

Quadri M, Fang M, Picillo M, Olgiati S, Breedveld GJ, Graafland J, Wu B, Xu F, Erro R, Amboni M, Pappata S, Quarantelli M, Annesi G, Quattrone A, Chien HF, Barbosa ER, Oostra BA, Barone P, Wang J, Bonifati V. (2013) Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism. Human mutation 34(9) 1208-15 [DOI PMID]

Cocito D, Paolasso I, Peci E, Spagone E, Lopiano L. (2013) Improvement of quality of life in patients with chronic inflammatory demyelinating polyneuropathy shifting from 16 to 20% subcutaneous immunoglobulins. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 34(11) 2061-2 [DOI PMID]

Abbruzzese G, Barone P, Bonuccelli U, Lopiano L, Antonini A. (2012) Continuous intestinal infusion of levodopa/carbidopa in advanced Parkinson's disease: ef fi cacy, safety and patient selection. Functional neurology 27(3) 147-54 [PMID]

Merola A, Zibetti M, Artusi CA, Rizzi L, Angrisano S, Lanotte M, Lopiano L, Rizzone MG. (2013) 80 Hz versus 130 Hz subthalamic nucleus deep brain stimulation: effects on involuntary movements. Parkinsonism & related disorders 19(4) 453-6 [DOI PMID]

Zibetti M, Rizzone M, Merola A, Angrisano S, Rizzi L, Montanaro E, Cicolin A, Lopiano L. (2013) Sleep improvement with levodopa/carbidopa intestinal gel infusion in Parkinson disease. Acta neurologica Scandinavica 127(5) e28-32 [DOI PMID]

Cocito D, Serra G, Paolasso I, Barila DA, Lopiano L, Cattel L. (2012) Economic and quality of life evaluation of different modalities of immunoglobulin therapy in chronic dysimmune neuropathies. Journal of the peripheral nervous system : JPNS 17(4) 426-8 [DOI PMID]

Alberio T, Pippione AC, Zibetti M, Olgiati S, Cecconi D, Comi C, Lopiano L, Fasano M. (2012) Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease. Scientific reports 2 953 [DOI PMID]

Torta DM, Vizzari V, Castelli L, Zibetti M, Lanotte M, Lopiano L, Geminiani G. (2012) Impulsivities and Parkinson's disease: delay aversion is not worsened by Deep Brain Stimulation of the subthalamic nucleus. PloS one 7(9) e43261 [DOI PMID]

Alberio T, Pippione AC, Comi C, Olgiati S, Cecconi D, Zibetti M, Lopiano L, Fasano M. (2012) Dopaminergic therapies modulate the T-CELL proteome of patients with Parkinson's disease. IUBMB life 64(10) 846-52 [DOI PMID]

Zibetti M, Merola A, Ricchi V, Marchisio A, Artusi CA, Rizzi L, Montanaro E, Reggio D, De Angelis C, Rizzone M, Lopiano L. (2013) Long-term duodenal levodopa infusion in Parkinson's disease: a 3-year motor and cognitive follow-up study. Journal of neurology 260(1) 105-14 [DOI PMID]

Antonini A, Barone P, Marconi R, Morgante L, Zappulla S, Pontieri FE, Ramat S, Ceravolo MG, Meco G, Cicarelli G, Pederzoli M, Manfredi M, Ceravolo R, Mucchiut M, Volpe G, Abbruzzese G, Bottacchi E, Bartolomei L, Ciacci G, Cannas A, Randisi MG, Petrone A, Baratti M, Toni V, Cossu G, Del Dotto P, Bentivoglio AR, Abrignani M, Scala R, Pennisi F, Quatrale R, Gaglio RM, Nicoletti A, Perini M, Avarello T, Pisani A, Scaglioni A, Martinelli PE, Iemolo F, Ferigo L, Simone P, Soliveri P, Troianiello B, Consoli D, Mauro A, Lopiano L, Nastasi G, Colosimo C. (2012) The progression of non-motor symptoms in Parkinson's disease and their contribution to motor disability and quality of life. Journal of neurology 259(12) 2621-31 [DOI PMID]

Antonini A, Abbruzzese G, Ferini-Strambi L, Tilley B, Huang J, Stebbins GT, Goetz CG, Barone P, Bandettini di Poggio M, Fabbrini G, Di Stasio F, Tinazzi M, Bovi T, Ramat S, Meoni S, Pezzoli G, Canesi M, Martinelli P, Maria Scaglione CL, Rossi A, Tambasco N, Santangelo G, Picillo M, Morgante L, Morgante F, Quatrale R, Sensi M, Pilleri M, Biundo R, Nordera G, Caria A, Pacchetti C, Zangaglia R, Lopiano L, Zibetti M, Zappia M, Nicoletti A, Quattrone A, Salsone M, Cossu G, Murgia D, Albanese A, Del Sorbo F. (2013) Validation of the Italian version of the Movement Disorder Society--Unified Parkinson's Disease Rating Scale. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 34(5) 683-7 [DOI PMID]

Milazzo V, Di Stefano C, Servo S, Zibetti M, Lopiano L, Maule S. (2012) Neurogenic orthostatic hypotension as the initial feature of Parkinson disease. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 22(4) 203-6 [DOI PMID]

Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP. (2012) The relationship between cerebral vascular disease and parkinsonism: The VADO study. Parkinsonism & related disorders 18(6) 775-80 [DOI PMID]

Alberio T, Lopiano L, Fasano M. (2012) Cellular models to investigate biochemical pathways in Parkinson's disease. The FEBS journal 279(7) 1146-55 [DOI PMID]

Merola A, Zibetti M, Artusi CA, Marchisio A, Ricchi V, Rizzi L, Angrisano S, Arduino N, Lanotte M, Rizzone M, Lopiano L. (2012) Subthalamic nucleus deep brain stimulation outcome in young onset Parkinson's disease: a role for age at disease onset? Journal of neurology, neurosurgery, and psychiatry 83(3) 251-7 [DOI PMID]

Marconi R, Antonini A, Barone P, Colosimo C, Avarello TP, Bottacchi E, Cannas A, Ceravolo MG, Ceravolo R, Cicarelli G, Gaglio RM, Giglia L, Iemolo F, Manfredi M, Meco G, Nicoletti A, Pederzoli M, Petrone A, Pisani A, Pontieri FE, Quatrale R, Ramat S, Scala R, Volpe G, Zappulla S, Bentivoglio AR, Stocchi F, Trianni G, Del Dotto P, De Gaspari D, Grasso L, Morgante F, Santangelo G, Fabbrini G, Morgante L. (2012) Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 33(3) 585-93 [DOI PMID]

Zibetti M, Merola A, Rizzi L, Ricchi V, Angrisano S, Azzaro C, Artusi CA, Arduino N, Marchisio A, Lanotte M, Rizzone M, Lopiano L. (2011) Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 26(13) 2327-34 [DOI PMID]

Elfferich P, Verleun-Mooijman MC, Maat-Kievit JA, van de Warrenburg BP, Abdo WF, Eshuis SA, Leenders KL, Hovestadt A, Zijlmans JC, Stroy JP, van Swieten JC, Boon AJ, van Engelen K, Verschuuren-Bemelmans CC, Lesnik-Oberstein SA, Tassorelli C, Lopiano L, Bonifati V, Dooijes D, van Minkelen R. (2011) Breakpoint mapping of 13 large parkin deletions/duplications reveals an exon 4 deletion and an exon 7 duplication as founder mutations. Neurogenetics 12(4) 263-71 [DOI PMID]

Ricchi V, Zibetti M, Angrisano S, Merola A, Arduino N, Artusi CA, Rizzone M, Lopiano L, Lanotte M. (2012) Transient effects of 80 Hz stimulation on gait in STN DBS treated PD patients: a 15 months follow-up study. Brain stimulation 5(3) 388-92 [DOI PMID]

Merola A, Zibetti M, Angrisano S, Rizzi L, Ricchi V, Artusi CA, Lanotte M, Rizzone MG, Lopiano L. (2011) Parkinson's disease progression at 30 years: a study of subthalamic deep brain-stimulated patients. Brain : a journal of neurology 134(Pt 7) 2074-84 [DOI PMID]

Merola A, Zibetti M, Angrisano S, Rizzi L, Lanotte M, Lopiano L. (2011) Comparison of subthalamic nucleus deep brain stimulation and Duodopa in the treatment of advanced Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 26(4) 664-70 [DOI PMID]

Alberio T, Bossi AM, Milli A, Parma E, Gariboldi MB, Tosi G, Lopiano L, Fasano M. (2010) Proteomic analysis of dopamine and alpha-synuclein interplay in a cellular model of Parkinson's disease pathogenesis. The FEBS journal 277(23) 4909-19 [DOI PMID]

Alberio T, Colapinto M, Natale M, Ravizza R, Gariboldi MB, Bucci EM, Lopiano L, Fasano M. (2010) Changes in the two-dimensional electrophoresis pattern of the Parkinson's disease related protein DJ-1 in human SH-SY5Y neuroblastoma cells after dopamine treatment. IUBMB life 62(9) 688-92 [DOI PMID]

Mila S, Albo AG, Corpillo D, Giraudo S, Zibetti M, Bucci EM, Lopiano L, Fasano M. (2009) Lymphocyte proteomics of Parkinson's disease patients reveals cytoskeletal protein dysregulation and oxidative stress. Biomarkers in medicine 3(2) 117-28 [DOI PMID]

Torta DM, Castelli L, Latini-Corazzini L, Banche A, Lopiano L, Geminiani G. (2010) Dissociation between time reproduction of actions and of intervals in patients with Parkinson's disease. Journal of neurology 257(8) 1356-61 [DOI PMID]

Fanali G, Rampoldi V, di Masi A, Bolli A, Lopiano L, Ascenzi P, Fasano M. (2010) Binding of anti-Parkinson's disease drugs to human serum albumin is allosterically modulated. IUBMB life 62(5) 371-6 [DOI PMID]

Zibetti M, Rizzi L, Colloca L, Cinquepalmi A, Angrisano S, Castelli L, Lanotte M, Lopiano L. (2010) Probable REM sleep behaviour disorder and STN-DBS outcome in Parkinson's Disease. Parkinsonism & related disorders 16(4) 265-9 [DOI PMID]

Zibetti M, Rosso M, Cinquepalmi A, Lanotte M, Angrisano S, Rabbia C, Valpreda S, Lopiano L. (2010) Asymptomatic deep venous thrombosis after deep brain stimulation for Parkinson disease. Stereotactic and functional neurosurgery 88(2) 94-7 [DOI PMID]

Zibetti M, Cinquepalmi A, Angrisano S, Lanotte M, Lopiano L. (2009) Management of antiparkinsonian therapy during chronic subthalamic stimulation in Parkinson's disease. Parkinsonism & related disorders 15 Suppl 4 S76-80 [DOI PMID]

Fassino S, Abbate Daga G, Gramaglia C, Piero A, Zibetti M, Castelli L, Cinquepalmi A, La Notte M, Lopiano L. (2010) Novelty-seeking in Parkinson's disease after deep brain stimulation of the subthalamic nucleus: a case-control study. Psychosomatics 51(1) 62-7 [DOI PMID]