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Cerebral Development and Pathology



We study the development of the central nervous system, from the embryo to the elderly, and some neurobiological mechanisms and common molecular pathways that guide normal development but can lead to neurodegeneration. In particular, we are studying the cerebral cortex, retina and spinal cord, and the organization of the visual, motor and somatosensory pathways.

We are interested in the molecular pathways that lead to the genesis and  death of neuronal cell, both during development and in experimental models of cerebral transient or permanent ischemia (cerebral infarction), acute and chronic glaucoma, epilepsy, motor neuron diseases and Alzheimer 's disease. Finally, we evaluate the immunomodulatory, neuroprotective and stimulating axonal growth role of stem cells.

Our research group is working in collaboration with biotechnology companies in order to develop innovative strategies to treat diseases of the nervous system.


Group’s ECR Sectors:

LS3_12 - Stem cell biology

LS3_2 - Cell biology and molecular transport mechanisms

LS3_3 - Cell cycle and division

LS3_4 - Apoptosis

LS3_5 - Cell differentiation, physiology and dynamics

LS3_6 - Organelle biology

LS3_7 - Cell signalling and cellular interactions

LS3_8 - Signal transduction

LS3_9 - Development, developmental genetics, pattern formation and embryology in animals

LS5_1 - Neuroanatomy and neurophysiology

LS5_10 - Neuroimaging and computational neuroscience

LS5_11 - Neurological disorders (e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease)

LS5_12 - Psychiatric disorders (e.g. schizophrenia, autism, Tourette’s syndrome, obsessive compulsive disorder, depression, bipolar disorder, attention deficit hyperactivity disorder

LS5_2 - Molecular and cellular neuroscience

LS5_3 - Neurochemistry and neuropharmacology

LS5_4 - Sensory systems (e.g. visual system, auditory system)

LS5_5 - Mechanisms of pain

LS5_6 - Developmental neurobiology

LS7_6 - Gene therapy, cell therapy, regenerative medicine


Perino A, Beretta M, Kilic A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo D, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E. (2014) Combined inhibition of PI3Kbeta and PI3Kgamma reduces fat mass by enhancing alpha-MSH-dependent sympathetic drive. Science signaling 7(352) ra110 [DOI  PMID]

Guglielmotto M, Monteleone D, Piras A, Valsecchi V, Tropiano M, Ariano S, Fornaro M, Vercelli A, Puyal J, Arancio O, Tabaton M, Tamagno E. (2014) Abeta1-42 monomers or oligomers have different effects on autophagy and apoptosis. Autophagy 10(10) 1827-43 [DOI  PMID]

Queiroga CS, Vercelli A, Vieira HL. (2015) Carbon monoxide and the CNS: challenges and achievements. British journal of pharmacology 172(6) 1533-45 [DOI  PMID]

Tomassy GS, Berger DR, Chen HH, Kasthuri N, Hayworth KJ, Vercelli A, Seung HS, Lichtman JW, Arlotta P. (2014) Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex. Science (New York, N.Y.) 344(6181) 319-24 [DOI  PMID]

d'Errico P, Boido M, Piras A, Valsecchi V, De Amicis E, Locatelli D, Capra S, Vagni F, Vercelli A, Battaglia G. (2013) Selective vulnerability of spinal and cortical motor neuron subpopulations in delta7 SMA mice. PloS one 8(12) e82654 [DOI  PMID]

Innocenti GM, Vercelli A, Caminiti R. (2014) The diameter of cortical axons depends both on the area of origin and target. Cerebral cortex (New York, N.Y. : 1991) 24(8) 2178-88 [DOI  PMID]

Mazzini L, Vercelli A, Ferrero I, Boido M, Cantello R, Fagioli F. (2012) Transplantation of mesenchymal stem cells in ALS. Progress in brain research 201 333-59 [DOI  PMID]

Tamagno E, Guglielmotto M, Monteleone D, Vercelli A, Tabaton M. (2012) Transcriptional and post-transcriptional regulation of beta-secretase. IUBMB life 64(12) 943-50 [DOI  PMID]

Verderio C, Muzio L, Turola E, Bergami A, Novellino L, Ruffini F, Riganti L, Corradini I, Francolini M, Garzetti L, Maiorino C, Servida F, Vercelli A, Rocca M, Dalla Libera D, Martinelli V, Comi G, Martino G, Matteoli M, Furlan R. (2012) Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Annals of neurology 72(4) 610-24 [DOI  PMID]

Boido M, Garbossa D, Fontanella M, Ducati A, Vercelli A. (2014) Mesenchymal stem cell transplantation reduces glial cyst and improves functional outcome after spinal cord compression. World neurosurgery 81(1) 183-90 [DOI  PMID]

Queiroga CS, Tomasi S, Wideroe M, Alves PM, Vercelli A, Vieira HL. (2012) Preconditioning triggered by carbon monoxide (CO) provides neuronal protection following perinatal hypoxia-ischemia. PloS one 7(8) e42632 [DOI  PMID]

Guglielmotto M, Monteleone D, Boido M, Piras A, Giliberto L, Borghi R, Vercelli A, Fornaro M, Tabaton M, Tamagno E. (2012) Abeta1-42-mediated down-regulation of Uch-L1 is dependent on NF-kappaB activation and impaired BACE1 lysosomal degradation. Aging cell 11(5) 834-44 [DOI  PMID]

Zhao Y, Spigolon G, Bonny C, Culman J, Vercelli A, Herdegen T. (2012) The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria. Molecular and cellular neurosciences 49(3) 300-10 [DOI  PMID]

Morello N, Bianchi FT, Marmiroli P, Tonoli E, Rodriguez Menendez V, Silengo L, Cavaletti G, Vercelli A, Altruda F, Tolosano E. (2011) A role for hemopexin in oligodendrocyte differentiation and myelin formation. PloS one 6(5) e20173 [DOI  PMID]

Boido M, Garbossa D, Vercelli A. (2011) Early graft of neural precursors in spinal cord compression reduces glial cyst and improves function. Journal of neurosurgery. Spine 15(1) 97-106 [DOI  PMID]

Bartolini A, Vigliani MC, Magrassi L, Vercelli A, Rossi F. (2011) G-CSF administration to adult mice stimulates the proliferation of microglia but does not modify the outcome of ischemic injury. Neurobiology of disease 41(3) 640-9 [DOI  PMID]

Grande V, Manassero G, Vercelli A. (2014) Neuroprotective and anti-inflammatory roles of the phosphatase and tensin homolog deleted on chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy. PloS one 9(12) e114554 [DOI  PMID]

Boido M, Piras A, Valsecchi V, Spigolon G, Mareschi K, Ferrero I, Vizzini A, Temi S, Mazzini L, Fagioli F, Vercelli A. (2014) Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis. Cytotherapy 16(8) 1059-72 [DOI  PMID]

Cauda F, Geminiani GC, Vercelli A. (2014) Evolutionary appearance of von Economo's neurons in the mammalian cerebral cortex. Frontiers in human neuroscience 8 104 [DOI  PMID]

Vercelli A, Boido M, Jhaveri S. (2012) NADPH diaphorase expression in superior colliculus of developing, aging and visually deafferented rats. Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 117(3) 142-66 [PMID]

Gunetti M, Tomasi S, Giammo A, Boido M, Rustichelli D, Mareschi K, Errichiello E, Parola M, Ferrero I, Fagioli F, Vercelli A, Carone R. (2012) Myogenic potential of whole bone marrow mesenchymal stem cells in vitro and in vivo for usage in urinary incontinence. PloS one 7(9) e45538 [DOI  PMID]

Cauda F, Vercelli A. (2013) How many clusters in the insular cortex? Cerebral cortex (New York, N.Y. : 1991) 23(11) 2779-80 [DOI  PMID]

Manassero G, Repetto IE, Cobianchi S, Valsecchi V, Bonny C, Rossi F, Vercelli A. (2012) Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse. Molecular pain 8 39 [DOI  PMID]

Garbossa D, Boido M, Fontanella M, Fronda C, Ducati A, Vercelli A. (2012) Recent therapeutic strategies for spinal cord injury treatment: possible role of stem cells.Neurosurgical review 35(3) 293-311; discussion 311 [DOI  PMID]

Cauda F, Costa T, Torta DM, Sacco K, D'Agata F, Duca S, Geminiani G, Fox PT, Vercelli A. (2012) Meta-analytic clustering of the insular cortex: characterizing the meta-analytic connectivity of the insula when involved in active tasks. NeuroImage 62(1) 343-55 [DOI  PMID]

Cauda F, Torta DM, Sacco K, D'Agata F, Geda E, Duca S, Geminiani G, Vercelli A. (2013) Functional anatomy of cortical areas characterized by Von Economo neurons.Brain structure & function 218(1) 1-20 [DOI  PMID]

Piras A, Gianetto D, Conte D, Bosone A, Vercelli A. (2011) Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure. PloS one 6(7) e22514 [DOI  PMID]

Tomasi S, Sarmientos P, Giorda G, Gurewich V, Vercelli A. (2011) Mutant prourokinase with adjunctive C1-inhibitor is an effective and safer alternative to tPA in rat stroke.PloS one 6(7) e21999 [DOI  PMID]

Buschini E, Piras A, Nuzzi R, Vercelli A. (2011) Age related macular degeneration and drusen: neuroinflammation in the retina. Progress in neurobiology 95(1) 14-25 [DOI  PMID]

Vieira HL, Alves PM, Vercelli A. (2011) Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species. Progress in neurobiology 93(3) 444-55 [DOI  PMID]

Cauda F, D'Agata F, Sacco K, Duca S, Geminiani G, Vercelli A. (2011) Functional connectivity of the insula in the resting brain. NeuroImage 55(1) 8-23 [DOI  PMID]

Last update: 21/08/2015 13:13
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