Neuropsychopharmacology
Principal Investigator: Prof.ssa Carola Eva
Group members:
- Carola Eva (Principal Investigator)
- Alessandra Oberto (Researcher)
Address and contacts:
- Carola Eva, 0116706608, carola.eva@unito.it; Alessandra Oberto, 0116706611, alessandra.oberto@unito.it
External website link
Main research activities of the research group
The neuropsychopharmacology laboratory lead by Prof.Eva is known for the well-established studies on the Y1 receptor for neuropeptide Y (NPY), which have contributed to elucidate the function of the NPY-Y1R signal in the limbic system. Recently, our research activity has been determinant in unraveling the role of the NPY-Y1R signal in the susceptibility to metabolic syndrome and in the differences that exist according to sex in the control of energy balance.
Furthermore, we are particularly interested in broadening the current knowledge about the phenotype-genotype correlation in different mouse models of neuropsychiatric and neurodevelopmental disorders, also studying the role of molecules involved in the control of brain plasticity. This could contribute to the identification of new molecular targets and more effective therapeutic interventions for diseases that need an approved therapy, such as fragile X syndrome.
List of 10 main publications
- Oberto A, Bertocchi I, Longo A, Bonzano S, Paterlini S, Meda C, Della Torre S, Palanza P, Maggi A and Eva C (2022). Hypothalamic NPY-Y1R Interacts with Gonadal Hormones in Protecting Female Mice against Obesity and Neuroinflammation. Int J Mol Sci. 2022 Jun 6;23(11):6351.
- Bertocchi I, Eltokhi A, Rozov A, Nguyễn Chi V, Jensen V, Bus T, Pawlak V, Serafino M, Sonntag H, Yang B, Burnashev N, Li SB, Obenhaus HA, Both M, Niewoehner B, Single FN, Briese M, Boerner T, Gass P, Rawlins JNP, Köhr G, Bannerman DM & Sprengel R (2021). Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. Commun Biol. 2021 Jan 8;4(1):59.
- Paterlini S, Panelli R, Gioiosa L,Parmigiani S, Franceschini P, Bertocchi I, Oberto A, Bartolomucci A, Eva C, Palanza P (2021). Conditional Inactivation of Limbic Neuropeptide Y-1 Receptors Increases Vulnerability to Diet-Induced Obesity in Male Mice. Int J Mol Sci. 2021 Aug 14;22(16):8745.
- Bertocchi I, Mele P, Ferrero G, Oberto A, Carulli D, Eva C (2020). NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression. Neuropharmacology. 2021 Feb 15;184:108425.
- Eva C, Oberto A, Longo A, Palanza P, Bertocchi I (2020). Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain. Neurosci Biobehav Rev. 2020 Dec;119:333-347.
- Bertocchi I, Oberto A, Longo A, Palanza P, Eva C (2020). Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions. Horm Behav. 2020 Sep;125:104824.
- Bertocchi I, Foglietta F, Collotta D, Eva C, Brancaleone V, Thiemermann C, Collino M (2020). The hidden role of NLRP3 inflammasome in obesity-related COVID-19 exacerbations: Lessons for drug repurposing. Br J Pharmacol. 2020 Nov;177(21):4921-4930
- Longo A, Fadda M, Brasso C, Mele P, Palanza P, Nanavaty I, Bertocchi I, Oberto A, Eva C (2018). Conditional inactivation of Npy1r gene induces mice behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram. Neuropharmacology. 2018 May 1;133:12-22.
- Longo A, Mele P, Bertocchi I, Oberto A, Bachmann A, Bartolomucci A, Palanza P, Sprengel R, Eva C (2014). Conditional Inactivation of Neuropeptide Y Y1 Receptors Unravels the Role of Y1 and Y5 Receptors Coexpressing Neurons in Anxiety. Biol Psychiatry. 2014 Dec 1;76(11):840-9.
- Bertocchi I, Oberto A, Longo A, Mele P, Sabetta M, Bartolomucci A, Palanza P, Sprengel R, and Eva C (2011). Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19395-400. doi: 10.1073/pnas.1109468108.