Staff

1. Sacchetti Benedetto (Coordinator)
2. Concina Giulia (Member)
3. Renna Annamaria (Member)
4. Eugenio Manassero (Member)
5. Cicciarelli Felice (PhD student)

Contacts

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ERC Sectors

Activity

The laboratory is interested in the analysis of neural mechanisms underlying the learning and memory processes, with particular attention to the formation of emotionally salient events memories. This study uses methods of behavioral analysis (classical and operant conditioning, spatial and relational memory test, baseline levels of fear and anxiety analysis), electrophysiological recordings (recordings by the patch-clamp technique, extracellular recordings in vitro, recordings in vivo) and immunohistochemical techniques (analysis of gene expression). The laboratory is part of the National Institute of Neuroscience and collaborates with international laboratories.

Group’s ECR Sectors:

LS5_2 - Molecular and cellular neuroscience

LS5_4 - Sensory systems (e.g. visual system, auditory system)

LS5_7 - Cognition (e.g. learning, memory, emotions, speech)

LS5_8 - Behavioural neuroscience (e.g. sleep, consciousness, handedness)

Publications

Overgeneralization of autonomic defensive reactions in obesity
2024-01-01 Manassero, Eugenio; Scarpina, Federica; Tagini, Sofia; Concina, Giulia; Scacchi, Massimo; Pollo, Antonella; Mauro, Alessandro; Sacchetti, Benedetto https://iris.unito.it/handle/2318/2027570

Medial anterior prefrontal cortex stimulation down-regulates implicit reactions to threats and prevents the
2024-01-01 Eugenio Manassero; Giulia Concina; Maria Clarissa Chantal Caraig; Pietro Sarasso; Adriana Salatino; Raffaella Ricci; Benedetto Sacchetti https://iris.unito.it/handle/2318/1985790

Hippocampus-to-amygdala pathway drives the separation of remote memories of related events
2024-01-01 Concina, Giulia; Milano, Luisella; Renna, Annamaria; Manassero, Eugenio; Stabile, Francesca; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1974815

Stabilizing Immature Dendritic Spines in the Auditory Cortex: A Key Mechanism for mTORC1-Mediated Enhancement of Long-Term Fear Memories
2023-01-01 Concina, Giulia; Gurgone, Antonia; Boggio, Elena M; Raspanti, Alessandra; Pizzo, Riccardo; Morello, Noemi; Castroflorio, Enrico; Pizzorusso, Tommaso; Sacchetti, Benedetto; Giustetto, Maurizio https://iris.unito.it/handle/2318/1951252

Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks
2022-01-01 Concina, Giulia; Renna, Annamaria; Milano, Luisella; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1875562

Sleep Deprivation During Memory Consolidation, but Not Before Memory Retrieval, Widens Threat Generalization to New Stimuli
2022-01-01 Manassero, E; Giordano, A; Raimondo, E; Cicolin, A; Sacchetti, B https://iris.unito.it/handle/2318/1867331

Expression of IGF-2 Receptor in the Auditory Cortex Improves the Precision of Recent Fear Memories and Maintains Detailed Remote Fear Memories Over Time
2021-01-01 Concina, Giulia; Renna, Annamaria; Milano, Luisella; Manassero, Eugenio; Stabile, Francesca; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1797620

Implicit and explicit systems differently predict possible dangers
2019-01-01 Manassero, Eugenio; Mana, Ludovica; Concina, Giulia; Renna, Annamaria; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1712283

The auditory cortex and the emotional valence of sounds

2019-01-01 Concina G.; Renna A.; Grosso A.; Sacchetti B. https://iris.unito.it/handle/2318/1721848

A neuronal basis for fear discrimination in the lateral amygdala
2018-01-01 Anna Grosso, Giulia Santoni, Eugenio Manassero, Annamaria Renna, Benedetto Sacchetti https://iris.unito.it/handle/2318/1662312

Lateral and Basal Amygdala Account for Opposite Behavioral Responses during the Long-Term Expression of Fearful Memories
2018-01-01 Manassero, Eugenio; Renna, Annamaria; Milano, Luisella; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1659885

Coherent activity between the prelimbic and auditory cortex in the slow-gamma band underlies fear discrimination
2018-01-01 Concina Giulia, Cambiaghi Marco, Renna Annamaria, Sacchetti Benedetto https://iris.unito.it/handle/2318/1711462

Reversible inactivation of the higher order auditory cortex during fear memory consolidation prevents memory-related activity in the basolateral amygdala during remote memory retrieval
2017-01-01 Cambiaghi, Marco; Renna, Annamaria; Milano, Luisella; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1651954

Region- and Layer-Specific Activation of the Higher Order Auditory Cortex Te2 after Remote Retrieval of Fear or Appetitive Memories
2017-01-01 Grosso, Anna; Cambiaghi, Marco; Milano, Luisella; Renna, Annamaria; Sacco, Tiziana; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1609922

Consensus Paper: Cerebellum and Emotion
2017-01-01 Adamaszek, M; D’Agata, F.; Ferrucci, R.; Habas, C.; Keulen, S.; Kirkby, K.C.; Leggio, M.; Mariën, P.; Molinari, M.; Moulton, E.; Orsi, L.; van Overwalle, F.; Papadelis, C.; Priori, A.; Sacchetti, B.; Schutter, D.J.; Styliadis, C.; Verhoeven, J. https://iris.unito.it/handle/2318/1609925

Higher order sensory cortex drives basolateral amygdala activity during the recall of remote, but not recently learned fearful memories
2016-01-01 Cambiaghi, Marco; Grosso, Anna; Likthtik, Ekaterina; Mazziotti, Raffaele; Concina, Giulia; Renna, Annamaria; Sacco, Tiziana; Joshua A. Gordon; Benedetto Sacchetti https://iris.unito.it/handle/2318/1542204

Mind-Brain Plasticity and
2016-01-01 Katiuscia Sacco; Benedetto Sacchetti https://iris.unito.it/handle/2318/1621178

Differential Recruitment of Auditory Cortices in the Consolidation of Recent Auditory Fearful Memories.
2016-01-01 Cambiaghi, Marco; Grosso, Anna; Renna, Annamaria; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1597706

Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia
2016-01-01 Alshammari, TK; Alshammari, MA; Nenov, MN; Hoxha, E; Cambiaghi M; Marcinno, A; James, TF; Singh, P; Labate, D; Li, J; Meltzer, HY; Sacchetti, B; Tempia, F; Laezza, F https://iris.unito.it/handle/2318/1611214

The assignment of the affective/motivational value to sensory stimuli is mediated by the Te2 cortex
2015-01-01 Grosso, Anna; Cambiaghi, Marco; Renna, Annamaria; Milano, Luisella; Merlo, Giorgio Roberto; Sacco, Tiziana; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1526461

The crosstalk within theta rhythms between secondary auditory cortex and basolateral amygdala is essential during fear memory recall
2015-01-01 Cambiaghi, Marco; Grosso, Anna; Concina, Giulia; Renna, Annamaria; Sacco, Tiziana; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1526452

The crosstalk within theta rhythms between secondary auditory cortex and basolateral amygdala is essential during remote fear memory recall
2015-01-01 Cambiaghi, Marco; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1526451

Reversal inactivation of Te2 impairs remote fear memory and BLA learned-plasticity
2015-01-01 Cambiaghi, Marco; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1526450

Value coding neurons in lateral amygdala are recruited by both unconditioned and learned emotional stimuli.
2015-01-01 Grosso, Anna; Cambiaghi, Marco; Renna, Annamaria; Milano, Luisella; Merlo, Giorgio Roberto; Sacco, Tiziana; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1526463

The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli
2015-01-01 Grosso, Anna; Cambiaghi, Marco; Renna, Annamaria; Milano, Luisella; Giorgio Roberto Merlo; Sacco, Tiziana; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1531395

Neural circuitry of long-term fear memories
2015-01-01 Cambiaghi, Marco; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1526449

Acute administration of nicotine into the higher order auditory Te2 cortex specifically decreases the fear-related charge of remote emotional memories
2015-01-01 Cambiaghi, Marco; Grosso, Anna; Renna, Annamaria; Concina, Giulia; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1526410

Auditory cortex involvement in emotional learning and memory
2015-01-01 Grosso, A; Cambiaghi, M; Concina, G; Sacco, T; Sacchetti, B https://iris.unito.it/handle/2318/1526425

Ivan Petrovich Pavlov (1849-1936)
2015-01-01 Cambiaghi, Marco; Sacchetti, Benedetto https://iris.unito.it/handle/2318/1526427

Secondary auditory cortex and basolateral amygdala interactions are essential during remote fear memory recall: The importance of theta rhythms
2014-01-01 Marco Cambiaghi; Benedetto Sacchetti https://iris.unito.it/handle/2318/154764

The recall of fear memory recruits theta activity in the secondary auditory cortex at recent and remote time-points
2014-01-01 M. Cambiaghi; B. Sacchetti https://iris.unito.it/handle/2318/154763

Analysis of the consequences of CIT-K-dependent cytokinesis failure in p53-proficient or p53-deficient mice
2013-01-01 F Bianchi; F Sgro; YJ Chang; M Gai; G Berto; N El Assawy; A Mauro; B Sacchetti; W Huttner; F Di Cunto https://iris.unito.it/handle/2318/132671

L'Emozione del Ricordo
2012-01-01 Benedetto Sacchetti https://iris.unito.it/handle/2318/151952

Involvement of cerebellum in emotional behavior.
2011-01-01 Strata P; Scelfo B; Sacchetti B. https://iris.unito.it/handle/2318/98139

Basolateral amygdala inactivation impairs learning-induced long-term potentiation in the cerebellar cortex.
2011-01-01 Zhu L; Sacco T; Strata P; Sacchetti B. https://iris.unito.it/handle/2318/86281

Learning-related feedforward inhibitory connectivity growth required for memory precision.
2011-01-01 Ruediger S; Vittori C; Bednarek E; Genoud C; Strata P; Sacchetti B; Caroni P. https://iris.unito.it/handle/2318/87228

Role of secondary auditory cortex in fear memory storage/retrieval.
2010-01-01 Sacco T.; Sacchetti B. https://iris.unito.it/handle/2318/86217

Role of secondary sensory cortices in emotional memory storage and retrieval in rats.
2010-01-01 Sacco T; Sacchetti B https://iris.unito.it/handle/2318/80580

Basolateral amygdala inactivation impairs learning-induced long-term potentiation in thecerebellar cortex
2009-01-01 L. ZHU; T. SACCO; P. STRATA; B. SACCHETTI https://iris.unito.it/handle/2318/86033

Zif268 is increased in secondary auditory cortices following fear memory reactivation
2009-01-01 T. SACCO; B. SACCHETTI https://iris.unito.it/handle/2318/86529

Cerebellum and emotional behavior
2009-01-01 Sacchetti B; Scelfo B; Strata P. https://iris.unito.it/handle/2318/64141

Il volto nascosto della paura / The Hidden Face of Fear
2008-01-01 Benedetto Sacchetti (supervisione scientifica) https://iris.unito.it/handle/2318/86807

Learning-related long-term potentiation of inhibitory synapses in the cerebellar cortex.
2008-01-01 SCELFO B; B. SACCHETTI; STRATA P https://iris.unito.it/handle/2318/39156

Cerebellum, emotions and fear
2007-01-01 Strata Piergiorgio, Scelfo Bibiana, Sacchetti Benedetto https://iris.unito.it/handle/2318/1880146

The effects of fear conditioning on cerebellar LTP and LTD.
2007-01-01 ZHU L; SCELFO B; HARTELL NA; STRATA P; B. SACCHETTI https://iris.unito.it/handle/2318/40647

Reversible inactivation of amygdala and cerebellum but not perirhinal cortex impairs reactivated fear memories.
2007-01-01 B. SACCHETTI; T. SACCO; P. STRATA https://iris.unito.it/handle/2318/40689

Membrane excitability and fear conditioning in cerebellar Purkinje cell
2006-01-01 L. ZHU; B. SCELFO; F. TEMPIA; B. SACCHETTI; P. STRATA https://iris.unito.it/handle/2318/37296

The cerebellum: synaptic changes and fear conditioning
2005-01-01 B. SACCHETTI; B. SCELFO; P. STRATA https://iris.unito.it/handle/2318/40880

Long-term synaptic changes induced in the cerebellar cortex by fear conditioning
2004-01-01 B. SACCHETTI; B. SCELFO; F. TEMPIA; P. STRATA https://iris.unito.it/handle/2318/42343

Role of the neocortex in consolidation of fear conditioning memories in rats.
2003-01-01 B. SACCHETTI; BALDI E; LORENZINI CA; BUCHERELLI C. https://iris.unito.it/handle/2318/9328

Time-dependent inhibition of hippocampal LTP in vitro following contextual fear conditioning in the rat.
2002-01-01 B. SACCHETTI; LORENZINI CA; BALDI E; BUCHERELLI C; ROBERTO M; TASSONI G; BRUNELLI M. https://iris.unito.it/handle/2318/9343

Cerebellar role in fear-conditioning consolidation.
2002-01-01 B. SACCHETTI; BALDI E; LORENZINI CA; BUCHERELLI C. https://iris.unito.it/handle/2318/9342

Differential contribution of some cortical sites to the formation of memory traces supporting fear conditioning.
2002-01-01 B. SACCHETTI; BALDI E; LORENZINI CA; BUCHERELLI C. https://iris.unito.it/handle/2318/9329

Long-lasting hippocampal potentiation and contextual memory consolidation.
2001-01-01 B. SACCHETTI; LORENZINI CA; BALDI E; BUCHERELLI C; ROBERTO M; TASSONI G; BRUNELLI M. https://iris.unito.it/handle/2318/9344

CAMKII inhibition in the parabrachial nuclei elicits conditioned taste aversion in rats.
2001-01-01 B. SACCHETTI; BALDI E; TASSONI G; BIELAVSKA E. https://iris.unito.it/handle/2318/9346

Pituitary adenylate cyclase-activating polypeptide hormone (PACAP) at very low dosages improves memory in the rat.
2001-01-01 B. SACCHETTI; LORENZINI CA; BALDI E; BUCHERELLI C; ROBERTO M; TASSONI G; BRUNELLI M. https://iris.unito.it/handle/2318/9345

Role of the perirhinal cortex in rats' conditioned taste aversion response memorization.
2000-01-01 TASSONI G; LORENZINI CA; BALDI E; B. SACCHETTI; BUCHERELLI C. https://iris.unito.it/handle/2318/9347

Effects of coupled perirhinal cortex and medial septal area, fimbria-fornix, entorhinal cortex tetrodotoxin inactivations on passive avoidance consolidation in the rat.
2000-01-01 BALDI E; AMBROGI LORENZINI C; B. SACCHETTI; TASSONI G; BUCHERELLI C. https://iris.unito.it/handle/2318/9348

Memorization of contextual and CS conditioned fear response (freezing) in a one-trial acquisition paradigm.
1999-01-01 B. SACCHETTI; AMBROQI LORENZINI C; BALDI E; TASSONI G; BUCHERELLI C. https://iris.unito.it/handle/2318/9351

Neural topography and chronology of memory consolidation: a review of functional inactivation findings.
1999-01-01 AMBROGI LORENZINI CG; BALDI E; BUCHERELLI C; B. SACCHETTI; TASSONI G. https://iris.unito.it/handle/2318/9353

A peculiar pattern of temporal involvement of rat perirhinal cortex in memory processing.
1999-01-01 TASSONI G; LORENZINI CA; BALDI E; B. SACCHETTI; BUCHERELLI C. https://iris.unito.it/handle/2318/9349

Auditory thalamus, dorsal hippocampus, basolateral amygdala, and perirhinal cortex role in the consolidation of conditioned freezing to context and to acoustic conditioned stimulus in the rat.
1999-01-01 B. SACCHETTI; LORENZINI CA; BALDI E; TASSONI G; BUCHERELLI C. https://iris.unito.it/handle/2318/9350

Effects of combined medial septal area, fimbria-fornix and entorhinal cortex tetrodotoxin inactivations on passive avoidance response consolidation in the rat.
1999-01-01 BALDI E; AMBROGI LORENZINI C; B. SACCHETTI; TASSONI G; BUCHERELLI C. https://iris.unito.it/handle/2318/9352

Entorhinal cortex and fimbria-fornix role in rat's passive avoidance response memorization.
1998-01-01 BALDI E; AMBROGI LORENZINI C; B. SACCHETTI; TASSONI G; BUCHERELLI C. https://iris.unito.it/handle/2318/9355

Chelerythrine, a specific PKC inhibitor, blocks acquisition but not consolidation and retrieval of conditioned taste aversion in rat.
1998-01-01 B. SACCHETTI; BIELAVSKA E. https://iris.unito.it/handle/2318/9356

Temporal characterization of subcortical nuclei in mnemonic processes: results of tetrodotoxin reversible inactivation studies in the rat
1998-01-01 AMBROGI LORENZINI CG; BALDI E; BUCHERELLI C; B. SACCHETTI; TASSONI G. https://iris.unito.it/handle/2318/9354

Analysis of mnemonic processing by means of totally reversible neural inactivations.
1997-01-01 AMBROGI LORENZINI CG; BALDI E; BUCHERELLI C; B. SACCHETTI; TASSONI G. https://iris.unito.it/handle/2318/9357

Role of ventral hippocampus in acquisition, consolidation and retrieval of rat's passive avoidance response memory trace.
1997-01-01 AMBROGI LORENZINI CG; BALDI E; BUCHERELLI C; B. SACCHETTI; TASSONI G. https://iris.unito.it/handle/2318/9373

2-Deoxy-D-galactose effects on passive avoidance memorization in the rat. Neurobiol Learn Mem. 1997 Nov;68(3):317-24.
1997-01-01 LORENZINI CG; BALDI E; BUCHERELLI C; B. SACCHETTI; TASSONI G. https://iris.unito.it/handle/2318/9372

Dissociation of exteroceptive and idiothetic orientation cues: effect on hippocampal place cells and place navigation.
1997-01-01 BURES J; FENTON AA; KAMINSKY Y; ROSSIER J; B. SACCHETTI; ZINYUK L. https://iris.unito.it/handle/2318/9374

Role of dorsal hippocampus in acquisition, consolidation and retrieval of rat's passive avoidance response: a tetrodotoxin functional inactivation study.
1996-01-01 LORENZINI CA; BALDI E; BUCHERELLI C; B. SACCHETTI; TASSONI G. https://iris.unito.it/handle/2318/9375