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Neurobiology of brain plasticity



The ability of adult central nervous system to repair itself following trauma, stroke or neurodegenerative diseases, and to recover the damaged functions is very low. Our ultimate purpose is to find new approaches to improve the deficit resulting from damage, and our research follows three strands. We study the brain development in order to understand how stem cells work and how the different cell types specify and integrate themselves. On this basis we develop cell replacement models in diseases such as cerebellar ataxia and Huntington's chorea. Then we investigate the role of glia and neural progenitors in pathological processes to activate their reparative properties in diseases such as stroke and multiple sclerosis. Finally, we study the mechanisms that regulate the ability of neurons to remodel their connections and the role of experience or rehabilitation in the regulation of these processes as well as in the recovery of the functions impaired by damage.


Group’s ECR Sectors:

LS5_1 - Neuroanatomy and neurophysiology

LS5_11 - Neurological disorders (e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease)

LS5_12 - Psychiatric disorders (e.g. schizophrenia, autism, Tourette’s syndrome, obsessive compulsive disorder, depression, bipolar disorder, attention deficit hyperactivity disorder

LS5_2 - Molecular and cellular neuroscience

LS5_6 - Developmental neurobiology



Leto K, Carulli D, Buffo A. (2014) Symposium in honor of Ferdinando Rossi: a passionate journey through the cerebellar mysteries. Cerebellum (London, England) 13(6) 791-4 [PMID]

Rolando C, Parolisi R, Boda E, Schwab ME, Rossi F, Buffo A. (2012) Distinct roles of Nogo-a and Nogo receptor 1 in the homeostatic regulation of adult neural stem cell function and neuroblast migration. The Journal of neuroscience : the official journal of the Society for Neuroscience 32(49) 17788-99 [DOI  PMID]

Boda E, Buffo A. (2010) Glial cells in non-germinal territories: insights into their stem/progenitor properties in the intact and injured nervous tissue. Archives italiennes de biologie 148(2) 119-36 [PMID]

Carulli D, Foscarin S, Faralli A, Pajaj E, Rossi F. (2013) Modulation of semaphorin3A in perineuronal nets during structural plasticity in the adult cerebellum. Molecular and cellular neurosciences 57 10-22 [DOI  PMID]

Faralli A, Bigoni M, Mauro A, Rossi F, Carulli D. (2013) Noninvasive strategies to promote functional recovery after stroke. Neural plasticity 2013 854597 [DOI  PMID]

Last update: 24/08/2015 12:57
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