Vai al contenuto principale

PICTURE
NOT AVAILABLE

for Cognitive and Behavioral Disorders

Staff

Activity

The research team cover all Major Neurocognitive Disorders (DSM-5), in particular Alzheimer's disease and frontotemporal lobar degeneration. We operate early diagnosis of disease, using CSF biomarkers, neuroimaging and neuropsychological testing. The patients are "screened" for the major genes of disease. In collaboration with several national and international research centers (Toronto, London, Houston) the group carries out genome-wide studies to isolate new risk factors of disease. Several Phase III studies are in progress, based on FDA protocols, to ensure safety and effectiveness of new symptomatic or disease-modyfing drugs  for neurodegenerative diseases. The Group participates to collaborative studies to evaluate the effects of metabolic drugs in experimental models of Alzheimer disease and the role of microvesicles isolated from CSF in the progression of the disease and in neurotoxicity mechanisms.

 

Group’s ECR Sectors:

LS2_6 - Molecular genetics, reverse genetics and RNAi

LS4_4 - Ageing

LS5_11 - Neurological disorders (e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease)

Publications

Benna P, Rubino E, Marino C, Montalenti E, Giovanna CM, Rainero I, Pinessi L. (2015) Paroxysmal perceptual alteration in a schizophrenic patient treated with paliperidone: A case report. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 27(3) 223-4 [PMID]

Negro E, D'Agata F, Caroppo P, Coriasco M, Ferrio F, Celeghin A, Diano M, Rubino E, de Gelder B, Rainero I, Pinessi L, Tamietto M. (2015) Neurofunctional Signature of Hyperfamiliarity for Unknown Faces. PloS one 10(7) e0129970 [DOI  PMID]

Ferrari R, Grassi M, Salvi E, Borroni B, Palluzzi F, Pepe D, D'Avila F, Padovani A, Archetti S, Rainero I, Rubino E, Pinessi L, Benussi L, Binetti G, Ghidoni R, Galimberti D, Scarpini E, Serpente M, Rossi G, Giaccone G, Tagliavini F, Nacmias B, Piaceri I, Bagnoli S, Bruni AC, Maletta RG, Bernardi L, Postiglione A, Milan G, Franceschi M, Puca AA, Novelli V, Barlassina C, Glorioso N, Manunta P, Singleton A, Cusi D, Hardy J, Momeni P. (2015) A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia. Neurobiology of aging [DOI  PMID]

D'Agata F, Orsi L, Cicerale A, Rubino E, Rainero I, Bergui M, Pinessi L. (2015) A review of recent advances in neuroimaging of frontotemporal lobar degeneration. Journal of neurosurgical sciences [PMID]

Zhang M, Xi Z, Zinman L, Bruni AC, Maletta RG, Curcio SA, Rainero I, Rubino E, Pinessi L, Nacmias B, Sorbi S, Galimberti D, Lang AE, Fox S, Surace EI, Ghani M, Guo J, Sato C, Moreno D, Liang Y, Keith J, Traynor BJ, St George-Hyslop P, Rogaeva E. (2015) Mutation analysis of CHCHD10 in different neurodegenerative diseases. Brain : a journal of neurology [DOI  PMID]

Xi Z, Zhang M, Bruni AC, Maletta RG, Colao R, Fratta P, Polke JM, Sweeney MG, Mudanohwo E, Nacmias B, Sorbi S, Tartaglia MC, Rainero I, Rubino E, Pinessi L, Galimberti D, Surace EI, McGoldrick P, McKeever P, Moreno D, Sato C, Liang Y, Keith J, Zinman L, Robertson J, Rogaeva E. (2015) The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients. Acta neuropathologica 129(5) 715-27 [DOI  PMID]

Borroni B, Turrone R, Galimberti D, Nacmias B, Alberici A, Benussi A, Caffarra P, Caltagirone C, Cappa SF, Frisoni GB, Ghidoni R, Marra C, Padovani A, Rainero I, Scarpini E, Silani V, Sorbi S, Tagliavini F, Tremolizzo L, Bruni AC. (2015) Italian Frontotemporal Dementia Network (FTD Group-SINDEM): sharing clinical and diagnostic procedures in Frontotemporal Dementia in Italy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 36(5) 751-7 [DOI  PMID]

Rainero I, Rubino E, Gallone S, Zavarise P, Carli D, Boschi S, Fenoglio P, Savi L, Gentile S, Benna P, Pinessi L, Dalla Volta G. (2014) KCNK18 (TRESK) genetic variants in Italian patients with migraine. Headache 54(9) 1515-22 [DOI  PMID]

Gallone S, Boschi S, Rubino E, De Martino P, Scarpini E, Galimberti D, Fenoglio C, Acutis PL, Maniaci MG, Pinessi L, Rainero I. (2014) Is HCRTR2 a genetic risk factor for Alzheimer's disease? Dementia and geriatric cognitive disorders 38(3-4) 245-53 [DOI  PMID]

Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, Hernandez I, Ruiz A, Boada M, Borroni B, Padovani A, Cruchaga C, Cairns NJ, Benussi L, Binetti G, Ghidoni R, Forloni G, Galimberti D, Fenoglio C, Serpente M, Scarpini E, Clarimon J, Lleo A, Blesa R, Waldo ML, Nilsson K, Nilsson C, Mackenzie IR, Hsiung GY, Mann DM, Grafman J, Morris CM, Attems J, Griffiths TD, McKeith IG, Thomas AJ, Pietrini P, Huey ED, Wassermann EM, Baborie A, Jaros E, Tierney MC, Pastor P, Razquin C, Ortega-Cubero S, Alonso E, Perneczky R, Diehl-Schmid J, Alexopoulos P, Kurz A, Rainero I, Rubino E, Pinessi L, Rogaeva E, St George-Hyslop P, Rossi G, Tagliavini F, Giaccone G, Rowe JB, Schlachetzki JC, Uphill J, Collinge J, Mead S, Danek A, Van Deerlin VM, Grossman M, Trojanowski JQ, van der Zee J, Deschamps W, Van Langenhove T, Cruts M, Van Broeckhoven C, Cappa SF, Le Ber I, Hannequin D, Golfier V, Vercelletto M, Brice A, Nacmias B, Sorbi S, Bagnoli S, Piaceri I, Nielsen JE, Hjermind LE, Riemenschneider M, Mayhaus M, Ibach B, Gasparoni G, Pichler S, Gu W, Rossor MN, Fox NC, Warren JD, Spillantini MG, Morris HR, Rizzu P, Heutink P, Snowden JS, Rollinson S, Richardson A, Gerhard A, Bruni AC, Maletta R, Frangipane F, Cupidi C, Bernardi L, Anfossi M, Gallo M, Conidi ME, Smirne N, Rademakers R, Baker M, Dickson DW, Graff-Radford NR, Petersen RC, Knopman D, Josephs KA, Boeve BF, Parisi JE, Seeley WW, Miller BL, Karydas AM, Rosen H, van Swieten JC, Dopper EG, Seelaar H, Pijnenburg YA, Scheltens P, Logroscino G, Capozzo R, Novelli V, Puca AA, Franceschi M, Postiglione A, Milan G, Sorrentino P, Kristiansen M, Chiang HH, Graff C, Pasquier F, Rollin A, Deramecourt V, Lebert F, Kapogiannis D, Ferrucci L, Pickering-Brown S, Singleton AB, Hardy J, Momeni P. (2014) Frontotemporal dementia and its subtypes: a genome-wide association study. The Lancet. Neurology 13(7) 686-99 [DOI  PMID]

Govone F, Vacca A, Rubino E, Gai A, Boschi S, Gentile S, Orsi L, Pinessi L, Rainero I. (2014) Lack of association between APOE gene polymorphisms and amyotrophic lateral sclerosis: a comprehensive meta-analysis. Amyotrophic lateral sclerosis & frontotemporal degeneration 15(7-8) 551-6 [DOI  PMID]

Xi Z, Rainero I, Rubino E, Pinessi L, Bruni AC, Maletta RG, Nacmias B, Sorbi S, Galimberti D, Surace EI, Zheng Y, Moreno D, Sato C, Liang Y, Zhou Y, Robertson J, Zinman L, Tartaglia MC, St George-Hyslop P, Rogaeva E. (2014) Hypermethylation of the CpG-island near the C9orf72 G(4)C(2)-repeat expansion in FTLD patients. Human molecular genetics 23(21) 5630-7 [DOI  PMID]

Thompson MD, Xhaard H, Sakurai T, Rainero I, Kukkonen JP. (2014) OX1 and OX2 orexin/hypocretin receptor pharmacogenetics. Frontiers in neuroscience 8 57 [DOI  PMID]

Sturiale CL, Fontanella MM, Gatto I, Puca A, Giarretta I, D'Arrigo S, Lofrese G, Rainero I, Gallone S, Pinessi L, Ducati A, Maira G, Pola R. (2014) Association between polymorphisms rs1333040 and rs7865618 of chromosome 9p21 and sporadic brain arteriovenous malformations. Cerebrovascular diseases (Basel, Switzerland) 37(4) 290-5 [DOI  PMID]

Carlino E, Frisaldi E, Rainero I, Asteggiano G, Cappa G, Tarenzi L, Vighetti S, Pollo A, Pinessi L, Benedetti F. (2014) Nonlinear analysis of electroencephalogram in frontotemporal lobar degeneration. Neuroreport 25(7) 496-500 [DOI  PMID]

Spalletta G, Caltagirone C, Padovani A, Sorbi S, Attar M, Colombo D, Cravello L. (2014) Cognitive and affective changes in mild to moderate Alzheimer's disease patients undergoing switch of cholinesterase inhibitors: a 6-month observational study. PloS one 9(2) e89216 [DOI  PMID]

Costa C, Tozzi A, Rainero I, Cupini LM, Calabresi P, Ayata C, Sarchielli P. (2013) Cortical spreading depression as a target for anti-migraine agents. The journal of headache and pain 14 62 [DOI  PMID]

Rainero I, Rubino E, Paemeleire K, Gai A, Vacca A, De Martino P, Gentile S, Sarchielli P, Pinessi L. (2013) Genes and primary headaches: discovering new potential therapeutic targets. The journal of headache and pain 14 61 [DOI  PMID]

Ostacoli L, Zuffranieri M, Cavallo M, Zennaro A, Rainero I, Pinessi L, Pacchiana Parravicini MV, Ladisa E, Furlan PM, Picci RL. (2013) Age of onset of mood disorders and complexity of personality traits. ISRN psychiatry 2013 246358 [DOI  PMID]

Fontanella M, Gallone S, Panciani PP, Garbossa D, Stefini R, Latronico N, Rubino E, Marengo N, Ducati A, Pinessi L, Rainero I. (2013) Vascular endothelial growth factor gene polymorphisms and intracranial aneurysms. Acta neurochirurgica 155(8) 1511-5 [DOI  PMID]

Borroni B, Grassi M, Bianchi M, Bruni AC, Maletta RG, Anfossi M, Pepe D, Cagnin A, Caffarra P, Cappa S, Clerici F, Daniele A, Frisoni GB, Galimberti D, Parnetti L, Perri R, Rainero I, Tremolizzo L, Turla M, Zanetti O, Padovani A. (2014) Estimating the inheritance of frontotemporal lobar degeneration in the Italian population. Journal of Alzheimer's disease : JAD 41(2) 371-6 [DOI  PMID]

Rubino E, Vacca A, Govone F, De Martino P, Pinessi L, Rainero I. (2013) Apolipoprotein E polymorphisms in frontotemporal lobar degeneration: a meta-analysis. Alzheimer's & dementia : the journal of the Alzheimer's Association 9(6) 706-13 [DOI  PMID]

Rubino E, Fenoglio P, Gallone S, Govone F, Vacca A, De Martino P, Giobbe ML, Boschi S, Pinessi L, Gentile S, Rainero I. (2013) Genetic variants in the NOTCH4 gene influence the clinical features of migraine. The journal of headache and pain 14 28 [DOI  PMID]

Galimberti D, Fenoglio C, Serpente M, Villa C, Bonsi R, Arighi A, Fumagalli GG, Del Bo R, Bruni AC, Anfossi M, Clodomiro A, Cupidi C, Nacmias B, Sorbi S, Piaceri I, Bagnoli S, Bessi V, Marcone A, Cerami C, Cappa SF, Filippi M, Agosta F, Magnani G, Comi G, Franceschi M, Rainero I, Giordana MT, Rubino E, Ferrero P, Rogaeva E, Xi Z, Confaloni A, Piscopo P, Bruno G, Talarico G, Cagnin A, Clerici F, Dell'Osso B, Comi GP, Altamura AC, Mariani C, Scarpini E. (2013) Autosomal dominant frontotemporal lobar degeneration due to the C9ORF72 hexanucleotide repeat expansion: late-onset psychotic clinical presentation. Biological psychiatry 74(5) 384-91 [DOI  PMID]

Villa C, Ridolfi E, Fenoglio C, Ghezzi L, Vimercati R, Clerici F, Marcone A, Gallone S, Serpente M, Cantoni C, Bonsi R, Cioffi S, Cappa S, Franceschi M, Rainero I, Mariani C, Scarpini E, Galimberti D. (2013) Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD 35(3) 487-94 [DOI  PMID]

Rubino E, Rainero I, Chio A, Rogaeva E, Galimberti D, Fenoglio P, Grinberg Y, Isaia G, Calvo A, Gentile S, Bruni AC, St George-Hyslop PH, Scarpini E, Gallone S, Pinessi L. (2012) SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Neurology 79(15) 1556-62 [DOI  PMID]

Xi Z, Zinman L, Grinberg Y, Moreno D, Sato C, Bilbao JM, Ghani M, Hernandez I, Ruiz A, Boada M, Moron FJ, Lang AE, Marras C, Bruni A, Colao R, Maletta RG, Puccio G, Rainero I, Pinessi L, Galimberti D, Morrison KE, Moorby C, Stockton JD, Masellis M, Black SE, Hazrati LN, Liang Y, van Haersma de With J, Fornazzari L, Villagra R, Rojas-Garcia R, Clarimon J, Mayeux R, Robertson J, St George-Hyslop P, Rogaeva E. (2012) Investigation of c9orf72 in 4 neurodegenerative disorders. Archives of neurology 69(12) 1583-90 [DOI  PMID]

Condello C, Fornaro R, Rainero I, Pinessi L, Savi LT. (2013) Importance of early treatment in case of spontaneous intracranial hypotension. Clinical neurology and neurosurgery 115(6) 839-40 [DOI  PMID]

Villa C, Ghezzi L, Fenoglio C, Clerici F, Marcone A, Benussi L, Ghidoni R, Gallone S, Serpente M, Cantoni C, Ridolfi E, Bonsi R, Cerami C, Cappa S, Binetti G, Franceschi M, Rainero I, Mariani C, Bresolin N, Scarpini E, Galimberti D. (2012) Genetics and expression analysis of the specificity protein 4 gene (SP4) in patients with Alzheimer's disease and frontotemporal lobar degeneration. Journal of Alzheimer's disease : JAD 31(3) 537-42 [DOI  PMID]

Gallone S, Di Stefano M, Fenoglio P, Rubino E, Criasia A, Pinessi L, Isaia G, Rainero I. (2011) Proinflammatory cytokine gene polymorphisms and susceptibility to Paget's disease of bone: an association study. Cytokine 56(3) 560-3 [DOI  PMID]

Carecchio M, Fenoglio C, Cortini F, Comi C, Benussi L, Ghidoni R, Borroni B, De Riz M, Serpente M, Cantoni C, Franceschi M, Albertini V, Monaco F, Rainero I, Binetti G, Padovani A, Bresolin N, Scarpini E, Galimberti D. (2011) Cerebrospinal fluid biomarkers in Progranulin mutations carriers. Journal of Alzheimer's disease : JAD 27(4) 781-90 [DOI  PMID]

Rainero I, Rubino E, Negro E, Gallone S, Galimberti D, Gentile S, Scarpini E, Pinessi L. (2011) Heterosexual pedophilia in a frontotemporal dementia patient with a mutation in the progranulin gene. Biological psychiatry 70(9) e43-4 [DOI  PMID]

Fontanella M, Rubino E, Crobeddu E, Gallone S, Gentile S, Garbossa D, Ducati A, Pinessi L, Rainero I. (2012) Brain arteriovenous malformations are associated with interleukin-1 cluster gene polymorphisms. Neurosurgery 70(1) 12-7 [DOI  PMID]

Serpente M, Fenoglio C, Villa C, Cortini F, Cantoni C, Ridolfi E, Clerici F, Marcone A, Benussi L, Ghidoni R, Martinelli Boneschi F, Gallone S, Cappa S, Binetti G, Franceschi M, Rainero I, Giordana MT, Mariani C, Bresolin N, Scarpini E, Galimberti D. (2011) Role of OLR1 and its regulating hsa-miR369-3p in Alzheimer's disease: genetics and expression analysis. Journal of Alzheimer's disease : JAD 26(4) 787-93 [DOI  PMID]

Fontanella M, Rainero I, Panciani PP, Schatlo B, Benevello C, Garbossa D, Carlino C, Valfre W, Griva F, Bradac GB, Ducati A. (2011) Subarachnoid hemorrhage and negative angiography: clinical course and long-term follow-up. Neurosurgical review 34(4) 477-84 [DOI  PMID]

Villa C, Fenoglio C, De Riz M, Clerici F, Marcone A, Benussi L, Ghidoni R, Gallone S, Cortini F, Serpente M, Cantoni C, Fumagalli G, Martinelli Boneschi F, Cappa S, Binetti G, Franceschi M, Rainero I, Giordana MT, Mariani C, Bresolin N, Scarpini E, Galimberti D. (2011) Role of hnRNP-A1 and miR-590-3p in neuronal death: genetics and expression analysis in patients with Alzheimer disease and frontotemporal lobar degeneration. Rejuvenation research 14(3) 275-81 [DOI  PMID]

Gallone S, Di Stefano M, Rainero I, Fenoglio P, Gravante E, Incardona S, Acutis PL, Maniaci MG, Isaia GC, Pinessi L. (2011) Detection of Exon 8 mutations in sqstm1/p62 gene by mutation-specific restriction enzyme digestion: a sensitive screening for Paget disease of bone. Panminerva medica 53(1) 71-2 [PMID]

Rainero I, Rubino E, Gallone S, Fenoglio P, Picci LR, Giobbe L, Ostacoli L, Pinessi L. (2011) Evidence for an association between migraine and the hypocretin receptor 1 gene. The journal of headache and pain 12(2) 193-9 [DOI  PMID]

Venturelli E, Villa C, Fenoglio C, Clerici F, Marcone A, Benussi L, Ghidoni R, Gallone S, Cortini F, Serpente M, Cantoni C, Fumagalli G, Ridolfi E, Cappa S, Binetti G, Franceschi M, Rainero I, Giordana MT, Mariani C, Bresolin N, Scarpini E, Galimberti D. (2011) BAG1 is a protective factor for sporadic frontotemporal lobar degeneration but not for Alzheimer's disease. Journal of Alzheimer's disease : JAD 23(4) 701-7 [DOI  PMID]

Rainero I, Ostacoli L, Rubino E, Gallone S, Picci LR, Fenoglio P, Negro E, Rosso C, De Martino P, De Marchi M, Furlan PM, Pinessi L. (2011) Association between major mood disorders and the hypocretin receptor 1 gene. Journal of affective disorders 130(3) 487-91 [DOI  PMID]

Borroni B, Bonvicini C, Galimberti D, Tremolizzo L, Papetti A, Archetti S, Turla M, Alberici A, Agosti C, Premi E, Appollonio I, Rainero I, Ferrarese C, Gennarelli M, Scarpini E, Padovani A. (2011) Founder effect and estimation of the age of the Progranulin Thr272fs mutation in 14 Italian pedigrees with frontotemporal lobar degeneration. Neurobiology of aging 32(3) 555.e1-8 [DOI  PMID]

Bachetti T, Di Zanni E, Lantieri F, Caroli F, Regis S, Filocamo M, Rainero I, Gallone S, Cilia R, Romano S, Savoiardo M, Pareyson D, Biancheri R, Ravazzolo R, Ceccherini I. (2010) A novel polymorphic AP-1 binding element of the GFAP promoter is associated with different allelic transcriptional activities. Annals of human genetics 74(6) 506-15 [DOI  PMID]

Carlino E, Benedetti F, Rainero I, Asteggiano G, Cappa G, Tarenzi L, Vighetti S, Pollo A. (2010) Pain perception and tolerance in patients with frontotemporal dementia. Pain 151(3) 783-9 [DOI  PMID]

Venturelli E, Villa C, Fenoglio C, Clerici F, Marcone A, Benussi L, Ghidoni R, Gallone S, Scalabrini D, Cortini F, Fumagalli G, Cappa S, Binetti G, Franceschi M, Rainero I, Giordana MT, Mariani C, Bresolin N, Scarpini E, Galimberti D. (2010) Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration? Neuroscience letters 482(3) 240-4 [DOI  PMID]

Fontanella M, Rainero I, Gallone S, Rubino E, Fornaro R, Fenoglio P, Valfre W, Vaula G, Benevello C, Ducati A, Pinessi L. (2010) Interleukin-1 cluster gene polymorphisms and aneurysmal subarachnoid hemorrhage. Neurosurgery 66(6) 1058-62; discussion 1062-3 [DOI  PMID]

Gennari L, Gianfrancesco F, Di Stefano M, Rendina D, Merlotti D, Esposito T, Gallone S, Fusco P, Rainero I, Fenoglio P, Mancini M, Martini G, Bergui S, De Filippo G, Isaia G, Strazzullo P, Nuti R, Mossetti G. (2010) SQSTM1 gene analysis and gene-environment interaction in Paget's disease of bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 25(6) 1375-84 [DOI  PMID]

Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G. (2010) Worldwide distribution of PSEN1 Met146Leu mutation: a large variability for a founder mutation. Neurology 74(10) 798-806 [DOI  PMID]

Galimberti D, Fenoglio C, Cortini F, Serpente M, Venturelli E, Villa C, Clerici F, Marcone A, Benussi L, Ghidoni R, Gallone S, Scalabrini D, Restelli I, Martinelli Boneschi F, Cappa S, Binetti G, Mariani C, Rainero I, Giordana MT, Bresolin N, Scarpini E. (2010) GRN variability contributes to sporadic frontotemporal lobar degeneration. Journal of Alzheimer's disease : JAD 19(1) 171-7 [DOI  PMID]

Cantoni C, Fenoglio C, Cortini F, Venturelli E, Villa C, Clerici F, Marcone A, Benussi L, Ghidoni R, Gallone S, Scalabrini D, Franceschi M, Cappa S, Binetti G, Mariani C, Rainero I, Giordana MT, Bresolin N, Scarpini E, Galimberti D. (2010) FUS/TLS genetic variability in sporadic frontotemporal lobar degeneration. Journal of Alzheimer's disease : JAD 19(4) 1317-22 [DOI  PMID]

Last update: 21/08/2015 15:35
Non cliccare qui!